intrinsic subtypes
Response and survival of breast cancer intrinsic subtypes following multi-agent neoadjuvant chemotherapy
... the intrinsic sub- types of breast cancer with response and survival outcomes in a large combined dataset of newly diagnosed patients treated with multi-agent neoadjuvant chemotherapy and we made the following ...
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Iteratively refining breast cancer intrinsic subtypes in the METABRIC dataset
... The breast cancer dataset disclosed by the METABRIC study (EGAS00000000083) con- tains cDNA microarray profiling of about 2000 samples performed on the Illumina HT-12 v3 platform (Illumina_Human_WG-v3) [16]. The samples ...
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Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies
... molecular subtypes (CMSs) and colorectal cancer intrinsic subtypes (CRISs) transcriptional signatures have potential clinical utility for improving prognostic/predictive patient ...molecular ...
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Prognostic Value of Intrinsic Subtypes in Hormone Receptor-Positive Metastatic Breast Cancer Treated With Letrozole With or Without Lapatinib.
... the intrinsic subtypes: Luminal A (not reached), Luminal B (32 months, 95% CI: 21–NA), HER2E (28 months, 95% CI: 17–NA) and Basal-like (19 months, 95% CI: ...9–NA). Intrinsic subtype added more ...
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Combining functional genomics strategies identifies modular heterogeneity of breast cancer intrinsic subtypes
... five intrinsic subtypes and normal breast tissue (Figure 2a and Additional file 4: Table S4) We performed a total of 30 pair-wise comparisons per module across all stages and ...for subtypes with ...
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Breast density, race, and intrinsic subtypes of breast cancer
... relevant subtypes on the basis of gene expression patterns: Luminal A, Luminal B, HER2 over- expressing, Basal-like, and ...These subtypes also show unique etiology ...
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Classification and risk stratification of invasive breast carcinomas using a real time quantitative RT PCR assay
... An ethnically diverse cohort of patients was studied using samples collected from the University of Utah Health Sciences Center, from the University of North Carolina, from Thomas Jef- ferson University, from the Maine ...
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<p>The prognosis comparison of different molecular subtypes of breast tumors after radiotherapy and the intrinsic reasons for their distinct radiosensitivity</p>
... or negative lymph nodes leading to curtailed DFS and deterioration of DM. 54,55 The highest incidence of LR is observed in HER2-enriched breast cancer patients with lymph node negativity; 56 however, no substantial ...
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Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large scale analysis of fresh frozen tissue samples
... five intrinsic molecular subtypes de- scribed from gene expression analysis, additional sub- types have been reported including a luminal C subtype [49], the molecular apocrine type [50], and a Claudin- low ...
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An integration of complementary strategies for gene expression analysis to reveal novel therapeutic opportunities for breast cancer
... Predicted subtypes, pathways, and chemosensitivities were performed on each data set independently, and then these results were combined to form a single data set for ...define intrinsic subtypes ...
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Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population
... from intrinsic subtypes among Taiwanese breast cancers, and provides an opportunity for develop- ing risk prediction models and dissecting the heteroge- neity within ER positive and negative breast cancers ...
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Intrinsic Subtype and Therapeutic Response Among HER2-Positive Breast Tumors from the NCCTG (Alliance) N9831 Trial.
... define intrinsic subtypes and assess their distribution and association with outcome within tumors from the North Central Cancer Treatment Group [NCCTG (Alliance)] N9831 trial of patients with early stage ...
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Differential tumor infiltration by T cells characterizes intrinsic molecular subtypes in breast cancer
... In addition, our results suggest that some subtypes might be more likely to respond to immunotherapeu- tic approaches than others. For example, a first clini- cal trial targeting the checkpoint inhibitory molecule ...
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A comparative study of swimmers, runners, cyclists and triathletes on sports motivation scale
... The mean and standard deviation of the factors of sport motivation for triathletes, runners, cyclists and rs are Intrinsic motivation to know (IMTK) (24.45 ± 2.46), (23.55 ± 3.40), (20.3 ± 5.06) and (18.45 ± ...
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An Annotation Schema for Preposition Senses in German
... With regard to multiple annotations, we define new categories consisting of the combination of the used categories. To calculate the weight of disagreement between two combined categories, we compute the weights of all ...
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Original Article Molecular subtypes of breast cancer with pathological features prevalent in Zhuang and Han ethnic groups in China: a study of 990 patients
... the subtypes of luminal A and Luminal B, age of onset in less than 35 years and 36-60 years old, Zhuang accounts for a higher proportion than the Han nationality, although in Zhuang and Han nationalities there was ...
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Avian influenza virus surveillance in migratory birds in Egypt revealed a novel reassortant H6N2 subtype
... Avian influenza virus (AIV), based on the antigenic prop- erties of the hemagglutinin (HA) and neuraminidase (NA) proteins, has 16 HA subtypes and 9 NA subtypes (Krammer et al. 2018). Furthermore, AIVs are ...
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The impact of study design and diagnostic approach in a large multi centre ADHD study Part 1: ADHD symptom patterns
... - comparison of frequencies of diagnostic subtypes across centres in the sibling sample - differences in medication across diagnostic subtypes and centres - comparison of centre effects [r] ...
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<p>Molecular subtype classification of papillary renal cell cancer using miRNA expression</p>
... expressed data of miRNAs to analyze molecular characteris- tics of KIRP and described three KIRP molecular subtypes. A better understanding of the biomarkers predicting clinical outcomes and the determinants of ...
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Intrinsic Differentiability and Intrinsic Regular Surfaces in Carnot groups
... The differentiability on Carnot groups also provides a natural way to introduce “intrinsic regular surfaces”. This concept was first introduced by Franchi, Serapioni and Serra Cassano in [44], [45], [47] in order ...
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