IR injury
Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence
... ischemia-reperfusion injury (IR injury) is still a severe problem worldwide, especially in the recipients with small-for-size liver graft [1, ...graft injury is an urgent need for liver ...
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Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
... A mouse model of 70% hepatic IR injury was established in this study. Mice were fasted for 16 hours before surgery, but had free access to water. The mice were intraperitone- ally injected with 1.25% sodium ...
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Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death
... lung injury and experimental sepsis, respectively [33, ...lung injury as a recent human clinical trial showed no improvement in physiological or clinical out- comes in ARDS patients that received ...
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Original Article 17β-Estradiol protects the liver against warm ischemia-reperfusion injury through the Akt/GSK-3β pathway
... (IR) injury is one of the common clinical pathophysiology processes, which also occurs during trauma, hemorrhagic shock, solid organ transplantation, liver resec- tion, etc [1, ...of IR injury ...
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Original Article Astragalus polysaccharide protects the heart from cardiac ischemic reperfusion mainly from regulating autophagy
... to be significantly enhanced with IR injury. Meanwhile, accumulation of GFP-LC3 dots was significant in primary cardiomyocytes of IR rats compared with sham group (Figure 4B). More importantly, we ...
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Original Article Effect of telmisartan preventscerebral ischemia-reperfusion injury-mediated oxidative stress and inflammation in a rat model
... cerebral IR injury is a result of ischemia, anoxia or sudden rupture hemorrhage of brain blood vessels caused by blockade of blood ...Cerebral IR injury may cause necrosis of tissues in ...
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Original Article Interleukin-10 deficiency increases renal inflammation and fibrosis in a mouse ischemia-reperfusion injury model
... after IR in KO ...after IR injury. A. Kidney tissue injury over time following 45 min of unilateral renal IR injury, Mice were sacrificed at various times and kidney samples were ...
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Original Article Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling
... (IR) injury serves as a major risk factor for acute renal failure in diverse clinical settings such as aortic bypass surgery, cardiopulmonary surgery, and kidney transplantation ...renal IR ...
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Is there a place for sevoflurane to prevent liver ischemia-reperfusion injury during liver transplantation?
... against IR injury ...after IR possibly through a mechanism that involves a decrease in release of lysosomal cathepsin B, in a model with isolated guinea pig hearts ...
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Cyclosporine-assisted adipose-derived mesenchymal stem cell therapy to mitigate acute kidney ischemia–reperfusion injury
... organ injury in the setting of IR ...the IR procedure than in animals that did not, consistent with other studies ...kidney IR injury was attenuated by either monotherapy alone and yet ...
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Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury
... In this study, we investigated the effects of food re- striction and ACE-I, because these treatments are stand- ard therapies in type II diabetic and metabolic syndrome patients. Several other drugs with possible ...
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Alterations in amino acid levels and metabolite ratio of spinal cord in rat with myocardial ischemia-reperfusion injury by proton magnetic resonance spectroscopy
... myocardial IR injury had higher concentration of Tau in the upper thoracic spinal cord (P < ...the IR group and the Control group in the upper thoracic spinal cord (P < ...myocardial IR ...
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MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II
... ischemia, IR, and heart failure ...after IR [10], but it is still unclear whether autophagy protects the heart against IR injury or contributes to cell ...
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Alterations in amino acid levels and metabolite ratio of spinal cord in rat with myocardial ischemia-reperfusion injury by proton magnetic resonance spectroscopy
... myocardial IR injury ...the IR group was significantly increased compared to the Control group ...the IR group, whereas myocardial cells in the control group were complete and arranged in ...
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Original Article Inhibition of neutral sphingomyelinase decreases arachidonic acid mediated inflammation in liver ischemia-reperfusion injury
... liver injury and shorten post-transplant hospital stay ...(IR) injury have been previously demonstrated [10, ...during IR, and attenuated serum ALT levels, hepatocellular necrosis, cy- ...
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Ischemia time impacts on respiratory chain functions and Ca2+-handling of cardiac subsarcolemmal mitochondria subjected to ischemia reperfusion injury
... and IR injury rather than their interfibrillar (IFM) counterparts ...of IR on calcium homeostasis, electron transport chain coupling and IMM polarization changes specifically in SSM in a Langendorff ...
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Vol 69, No 1 (2017)
... (IR) injury in ...the IR group and the berberine+IR ...the IR group, rats pretreated with berberine prior to IR had significantly reduced intestinal ischemia/reperfusion ...
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Type 2 diabetes mellitus worsens neurological injury following cardiac arrest: an animal experimental study
... A precipitating pathology that may co-exist with cardiac arrest is type 2 diabetes mellitus (T2DM). Recent large clinical trials and retrospective studies have shown that the prevalence of diabetes mellitus is more ...
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25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity
... heart IR injury in mice, it was administered intraperitoneally (10 mg/kg) 10 min before reperfusion procedure in IR injury model ...undergoing IR injury (the vehicle group) ...
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Original Article Fibroblast growth factor-2 ameliorates acute renal ischemia and reperfusion injury through ERK1/2-PARP-1 signaling pathway
... tubular injury in kidneys from sham operation ...by IR injury, are further elevated in kidneys injected with r-FGF compared with kidneys treated with normal ...by IR injury is aggravat- ...
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