Iron Overload
A Review on Iron Chelators in Treatment of Iron Overload Syndromes
... iron overload complications and related therapeutic ...of iron overload in patients with thalassemia ...of iron chelation therapy, Deferasirox, approved by FDA in 2005 and Canada Health ...
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Global longitudinal strain as an Indicator of cardiac Iron overload in thalassemia patients
... Conventional echocardiography which examines such factors as Ejection fraction (EF) and FS (Fractional short- ening) is not sufficiently accurate for early diagnosis of cardiac iron overload. Previous ...
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Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans
... to iron-induced fat accumulation (Figure 5, F and G, Figure ...that iron promoted the accumulation of VIT-2 protein in LDs (Figure 5, D and ...to iron- promoted oleic acid uptake (Figure 5I), ...
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Management of iron overload in the Canadian hematology/oncology population: Implications for nursing practice
... of iron overload in MDS patients, the clinical importance of iron overload and its management in this patient population is somewhat controversial since data in this area has primarily been ...
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Iron Overload in Children Who Are Treated for Acute Lymphoblastic Leukemia Estimated by Liver Siderosis and Serum Iron Parameters
... The correlation of ferritin to TIS remained signifi- cant during the follow-up of 1 to 3 years. This indi- cates that ferritin may be the most useful parameter for long-term monitoring of the resolution of an ex- tensive ...
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Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia
... elemental iron. At the time of liver biopsy, his iron saturation and serum ferritin level were 98% (normal range, 20%–50%) and 1100 ng/mL (normal range, 10–140 ng/mL), ...Visceral iron burden was ...
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Original Article Evaluation of iron-chelating activity of Caulerpa racemosa in iron-dextran induced iron overload in an experimental model of thalassemia
... cardiac iron deposition, which leads to life threatening high output cardiac failure ...chelating iron molecules, toxicity is an expected result of iron overload due to the remarkable increase ...
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Exogenous Apotransferrin and Exchange Transfusions in Hereditary Iron Overload Disease
... and iron overload with hemosiderosis of the liver, increased serum ferritin concentration, hypotransferrinemia, and increased transferrin iron ...
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Assessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
... is iron accumulation in vital ...of iron deposition in the pancreas can reduce cardiac ...pancreatic iron overload in transfusion dependent thalassemia, the correlation between pancreas with ...
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Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload
... Iron overload is a major problem in patients with major ...safe iron chelator protocol with high compliance rate plays an important role in treatment of these ...
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Treating thalassemia major-related iron overload: the role of deferiprone
... three iron chelators, new imaging techniques that allow specific organ assessment of the degree of iron overload, and improvement in the treatment of ...for iron chelation in the ...body ...
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Efficient clearance of non transferrin bound iron by rat liver Implications for hepatic iron loading in iron overload states
... with iron overload, a significant fraction of the total iron in plasma circulates in the form of low molecular weight complexes not bound to ...of iron by the liver may account for the hepatic ...
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Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β thalassemic mice
... Excessive iron absorption is one of the main features of β-thalassemia and can lead to severe morbidity and ...of iron in the liver, spleen, and kidneys markedly increases. Iron overload is ...
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An artefact of PET attenuation correction caused by iron overload of the liver in clinical PET-MRI
... Background: Attenuation correction is one of the most important steps in producing quantitative PET image data. In hybrid PET-MRI systems, this correction is far from trivial, as MRI data are not correlated to PET ...
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Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload
... cardiac iron loading that is not present for cross-sec- tional measures of blood iron (ferritin) or liver iron ...cardiac iron loading are ...non-cardiac iron loaded TM patients are ...
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Investigation Into Beneficial Effects of Triticum Aestivum (Wheat Grass) in Iron Overload Complications
... Certified samples of species of wheat Triticum aestivum, was acquired from Wheat Research Center, Gujarat Krushi University, Junagadh, Gujarat. The authenticity of these certified samples was also confirmed by comparing ...
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Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
... heme iron and non-heme iron. The latter mainly including iron stored in ferritin and ...increased iron in the striatum could be a causal factor of the symptoms of HD [15, ...in iron ...
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The role of MR imaging in detection of hepatic iron overload in patients with cirrhosis of different origins
... injury iron over- load accompany severe necroinflammatory process ...of iron accumulation may act through increase of iron absorption or influence on hep- cidin and transferrin expression ...hepatic ...
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Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload
... of iron-protein complexes in hepatocyte lysosomes, little is known about the effects of excess iron on these ...experimental iron overload on hepatocyte lysosomal structure, physicochemical ...
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Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection
... of iron was consistent with the location of hepatocyte apoptosis fol- lowing ...that iron overload resulted in the production of ROS and lipid peroxidation, which was thought to contribute to hep- ...
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