IRS-2
Complementary roles of IRS 1 and IRS 2 in the hepatic regulation of metabolism
... of IRS-1 and IRS-2 in liver also affected the function of other metabolic ...Although IRS tyrosine phos- phorylation and protein levels in muscle and fat were not affected by the knockdown of ...
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The combined role of allelic variants of IRS-1 and IRS-2 genes in susceptibility to type2 diabetes in the Punjabi Pakistani subjects
... surface, IRS-1, a docking protein is phosphorylated and activates phosphatidyl inositol 3-kinase ...of IRS-1 in the fat ...of IRS-1 [12]. Downstream IRS-1, the main docking protein found in ...
6
Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... that IRS-2 rs1805097 G>A polymor- phism was associated with a significantly de- creased risk of colon cancer, but not mixed co- lorectal cancer and rectal ...of IRS-2 rs- 1805097 G>A ...
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Overexpression of the Shb SH2 Domain-Protein in Insulin-Producing Cells Leads to Altered Signaling Through the IRS-1 and IRS-2 Proteins
... of IRS-2 in cells with long- term Shb ...with IRS-1 was observed in the nonstimulated Shb cells. The alterations of IRS-1 and IRS-2 phosphorylation are presumably a conse- quence ...
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Differential regulation of insulin receptor substrates 1 and 2 (IRS 1 and IRS 2) and phosphatidylinositol 3 kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
... of IRS-1 and IRS-2 in signaling to the phosphatidyl- inositol (PI) 3-kinase pathway in the ob/ob mouse, a model of the insulin resistance of obesity and non–insulin-depen- dent diabetes ...both ...
10
Tissue specific insulin resistance in mice with mutations in the insulin receptor, IRS 1, and IRS 2
... of IRS molecules as mediators of insulin sig- naling through the insulin receptor is firmly estab- lished ...different IRS mole- cules play redundant or selective roles in insulin action in different ...
8
The Gly972→Arg amino acid polymorphism in IRS 1 impairs insulin secretion in pancreatic β cells
... and 2 (IRS-1 and IRS-2) (13–15). IRS molecules are rapidly tyrosine phosphorylated after insulin stimulation and serve as multisite dock- ing proteins for various effector molecules ...
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Effect of dezocine pretreatment on emergence agitation and related internal environment changes in children with general anesthesia surgery
... Activation of stress response during operation and anesthesia involves the activation of multiple signaling pathways in the cells [12] . Endoplasmic reticulum stress is an important form of stress reaction activation, ...
5
Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice
... PCOS; IRS-1 expression was higher and IRS-2 expression was lower in PCOS ...vitro, IRS-1 expression was reduced and IRS-2 expression was enhanced bringing the levels of ...
8
Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
... of IRS-2 tyrosine phosphorylation was not in- creased by stimulation of HCD-57 cells with stem cell factor (data not ...of IRS-2 tyrosine phosphory- lation in the absence of Epo than ...
9
Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population
... type 2 diabetes [8]. This predisposition to type 2 diabetes is a consequence of defects in both in- sulin action [9] and insulin secretion ...in IRS-1 and IRS-2 have been implicated in ...
8
Fructose-induced stress signaling in the liver involves methylglyoxal
... of IRS-1 and reduced insulin-stimulated tyrosine phosphorylation of IRS-1 and IRS-2 ...of IRS-1 phosphorylation; ceramide, oxidative stress and methylglyoxal ...
8
Vol 70, No 4 (2018)
... the IRS proteins, most notably through liver X receptor A (LXRA) activa- tion ...D). IRS-1 knockdown alone did not have any effect on Cyp7a1 expression and decreased hepatic IRS- 2 expression ...
8
Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
... of IRS-1 and/or -2 variant (s) to the p85 regulatory subunit of the PI3-kinase and a decrease in PI3-kinase ...significant IRS-1 and/or -2 -induced decrease in phosphorylation of glycogen ...
21
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... and 2) to examine the relationships be- tween gene polymorphisms and components of ...of IRS-1 and IRS-2 genes were amplified by polymerase chain reaction ...the IRS-1 gene (p < ...
7
Insights into insulin resistance and type 2 diabetes from knockout mouse models
... of IRS-1 and IRS-2, and association of the p85 subunit of PI 3-kinase with IRS-1 are all ...at 2 months in the double heterozygotes than in either of the single ...and IRS-1 ...
8
Entomological and parasitological impacts of indoor residual spraying with DDT, alphacypermethrin and deltamethrin in the western foothill area of Madagascar
... At the end of the 1960s all DDT use was banned in the majority of developed countries but exceptions were made for countries needing essential public health inter- ventions. However, its low cost and persistence make DDT ...
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Reasoned Explanation and IRS Adjudication
... Currently, there is not a single rule as to required explanations that cuts across and operates with uniformity in all areas of IRS adjudication. Instead, there are multiple sources of duties of explanation. ...
64
Insulin Resistance Syndrome- the Sensitive IRS
... fatty and trans fatty acids and dietary patterns such as high glycemic index and Western diet all. 207 [r] ...
27
27114A AFI IRS May86 pdf
... /YI*/SR*/DIR: When moving data from FIFO, if no data is available at the FIFO outputs, and no data exists in register furthest from FIFO outputs, data will not be in register nearest FIF[r] ...
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