Isocitrate Dehydrogenase
Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
... in isocitrate dehydrogenase 1 ( IDH1 ) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D -2-hydroxyglutarate ( D- 2-HG) at ...
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Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia
... The isocitrate dehydrogenase ( IDH ) 1 and 2 genes were identified to be mutated in AML ...catalyze isocitrate oxidation to α-ketoglutarate (α-KG) and the cofactor NADPH is gen- ...
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Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas
... of isocitrate dehydrogenase 1 (IDH1) mutations in glioma is one of the major discoveries mediating metabolomics and oncogenesis ...of isocitrate into α-ketoglutarate (α-KG), simultaneously converting ...
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<p>Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma</p>
... converts isocitrate to α -KG through the reduction of NADP + to NADPH, and mutations of IDH1 and IDH2 exhibited neomorphic enzymatic activity, resulting in the production of an onco-metabolite named ...
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Autocrine IFN I inhibits isocitrate dehydrogenase in the TCA cycle of LPS stimulated macrophages
... of isocitrate dehydrogenase (IDH) (2, 3), the enzyme that converts isocitrate to α-ketoglutarate and a key check- point in the TCA ...succinate dehydrogenase (SDH) in the electron transport ...
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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
... Alteration in cellular metabolism is a key pathway to the development of cancer. Most oncogenes and tumor suppressors influence cellular metabolism, and there are examples of mutations in metabolic genes that become ...
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Identification, Molecular Cloning, and Evaluation of Potential Use of Isocitrate Dehydrogenase II of Mycobacterium bovis BCG in Serodiagnosis of Tuberculosis
... Diagnosis of tuberculosis is time-consuming and requires infrastructures which are often not available in countries with high incidences of the disease. In the present study, an 82-kDa protein antigen was isolated by ...
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Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
... The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle, which can catalyze the conversion of isocitrate to α-ketoglutarate (KG), thus generating ...
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<p>Detection Of Mutations In The Isocitrate Dehydrogenase Genes (IDH1/IDH2) Using castPCR<sup>TM</sup> In Patients With AML And Their Clinical Impact In Mexico City</p>
... however, at the molecular level, a variety of mutations have been identi fi ed, in which genes that regulate cell prolifera- tion, differentiation and apoptosis are altered. 4,5 These alterations impact the prognosis and ...
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Prognostic and diagnostic potential of isocitrate dehydrogenase 1 in esophageal squamous cell carcinoma
... We aimed to investigate the pattern of expression and clinical significance of isocitrate dehydrogenase 1(IDH1) in esophageal squamous cell carcinoma (ESCC). The IDH1 expression was determined by ...
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Isocitrate Dehydrogenase Is Important for Nitrosative Stress Resistance in Cryptococcus neoformans, but Oxidative Stress Resistance Is Not Dependent on Glucose-6-Phosphate Dehydrogenase
... -dependent isocitrate dehydrogenase (Idp) (55), a ubiquitous enzyme that in systems ranging from humans to yeasts to plants has been found in the cytosol, peroxisomes, or mitochondria (12, 19, ...-dependent ...
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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
... Approximately 40–45% of young and 10–20% of elderly AML patients treated with standard therapy will be cured. There are no more than 10% of relapsed or refractory (R/ R) AML [1–4]. Advancements in next-generation sequen- ...
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Study of Isocitrate Dehydrogenase 1and 2 Mutations in Adult Egyptian Patients with Denovo Acute Myeloblastic Leukemia, Their Relation to Clinical Characteristics, FLT3/ITD and Nucleophosmin 1 Mutations and Impact on Treatment Outcome
... For patients within the intermediate risk category, the optimal therapeutic strategies are still largely unclear and the outcome of treatment is heterogeneous. This led to the discoveries that have highlighted an ...
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Original Article Glioblastoma with PNET-like components has a higher fre- quency of isocitrate dehydrogenase 1 ( IDH1 ) mutation and likely a better prognosis than primary glioblastoma
... Abstract: Glioblastoma with primitive neuroectodermal tumor-like components (GBM-PNET), a rare variant of glioblas- toma, poses both diagnostic and therapeutic challenges. Ten patients with GBM-PNET were investigated ...
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Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients
... trate dehydrogenase (IDH) is one the enzymes that, if defective, lead to abnormal cellular metabolism ...of isocitrate into a- ketoglutarate (a-KG) by utilizing nicotinamide adenine dinucleotide (NAD) or ...
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<p>Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients</p>
... Our results show that IDH1 mutation in gliomas is associated with lower levels of chronic in fl ammation which could account for the improved prognosis in this group of patients.. These fi[r] ...
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High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma
... convert isocitrate to α-KG), is frequently mutated in cancer, particularly in secondary glioblastoma [30], cy- togenetically normal acute myeloid leukemia (AML) [31], cartilaginous tumors [32], and intrahepatic ...
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THE INHERITANCE OF ENZYME VARIANTS FOR TYROSINE AMINOTRANSFERASE, NADP-DEPENDENT MALATE DEHYDROGENASE, NADP-DEPENDENT ISOCITRATE DEHYDROGENASE, AND TETRAZOLIUM OXIDASE IN TETRAHYMENA PYRIFORMIS, SYNGEN 1
... The F, hybrid clones showed both parental isozymes and an isozyme of intermediate mobility, which is presumed to indicate this enzyme is a dimer.. TAIT (1970) has examined t[r] ...
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D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma
... To explore the potential role of different mutation types in the formation of astrocytomas and oligodendro- glial tumors, we determined the enzyme kinetics of wild type IDH1 and with the[r] ...
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Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type
... The aim of the present study was to identify a miRNA signature of prognostic value for IDH1 wild-type GBM patients using miRNA expression dataset from the The Cancer Genome Atlas (TCGA).[r] ...
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