Isocitrate dehydrogenase 1
Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
... in isocitrate dehydrogenase 1 ( IDH1 ) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D -2-hydroxyglutarate ( D- ...
13
Prognostic and diagnostic potential of isocitrate dehydrogenase 1 in esophageal squamous cell carcinoma
... We aimed to investigate the pattern of expression and clinical significance of isocitrate dehydrogenase 1(IDH1) in esophageal squamous cell carcinoma (ESCC). The IDH1 expression was determined by ...
13
Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas
... of isocitrate dehydrogenase 1 (IDH1) mutations in glioma is one of the major discoveries mediating metabolomics and oncogenesis ...of isocitrate into α-ketoglutarate (α-KG), simultaneously ...
12
Original Article Glioblastoma with PNET-like components has a higher fre- quency of isocitrate dehydrogenase 1 ( IDH1 ) mutation and likely a better prognosis than primary glioblastoma
... Abstract: Glioblastoma with primitive neuroectodermal tumor-like components (GBM-PNET), a rare variant of glioblas- toma, poses both diagnostic and therapeutic challenges. Ten patients with GBM-PNET were investigated ...
10
D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma
... of IDH1 mutations in gliomas other than R132H. Suffi- cient formalin fixed and paraffin embedded tissue was available from 9 tumors with R132C, 6 tumors with R132G and 1 each with R132S and R132L. Due to loss of ...
10
<p>Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients</p>
... and other HIF1-regulated in fl ammatory mediators, espe- cially in lower grade gliomas. On the other hand, as the tumor grows, the level of hypoxia increases, leading to HIF1 upregulation through other hypoxia-induced ...
10
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients
... Results: The prevalence of IDH1 and IDH2 mutations was 8.7% (20/230) and 10.4% (24/230), respectively. Six missense mutations were identified among IDH1-mutated cases; p.R132H (n = 8), p.R132C (n = 6), p.R132S (n = 2), ...
10
Original Article A population-based study of high-grade gliomas and mutated isocitrate dehydrogenase 1
... We present data from a population-based ret- rospective study of patients with high-grade gliomas. A sub-group of patients characterized by age > 70 years, PS 2-4, and a dismal progno- sis was identified. Patients ...
10
Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type
... A recent study, which examined the expression data of 305 miRNAs from 222 GBM samples in TCGA dataset, identified a 10-miRNA prognostic signature [15]. The 10-miRNA signature is partially consistent with the 23- miRNA ...
5
Prognostic value of isocitrate dehydrogenase 1, O6 methylguanine DNA methyltransferase promoter methylation, and 1p19q co deletion in Japanese malignant glioma patients
... strategies. However, information on these three genetic changes might not always be necessary. GBA and AA patients with IDH1 mutations and MGMT methylation had longer survival times than those without such genetic ...
10
Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
... The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle, which can catalyze the conversion of isocitrate to α-ketoglutarate (KG), thus generating ...
17
MR Imaging–Based Analysis of Glioblastoma Multiforme: Estimation of IDH1 Mutation Status
... BACKGROUND AND PURPOSE: Glioblastoma multiforme is highly aggressive and the most common type of primary malignant brain tumor in adults. Imaging biomarkers may provide prognostic information for patients with this ...
8
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
... Alteration in cellular metabolism is a key pathway to the development of cancer. Most oncogenes and tumor suppressors influence cellular metabolism, and there are examples of mutations in metabolic genes that become ...
15
Study of Isocitrate Dehydrogenase 1and 2 Mutations in Adult Egyptian Patients with Denovo Acute Myeloblastic Leukemia, Their Relation to Clinical Characteristics, FLT3/ITD and Nucleophosmin 1 Mutations and Impact on Treatment Outcome
... Background: Acute myeloid leukaemia (AML) is a malignancy that is heterogeneous in nature characterized by genetic abnormalities some of which are established in the diagnosis and prognosis of the disease. An additional ...
8
<p><em>IDH1</em>-mutated relapsed or refractory AML: current challenges and future prospects</p>
... of isocitrate dehydrogenase 1 (IDH1 mut ), present in 7 – 14% of AML patients, have been discovered recently, opening the door to targeted agents aiming to improve the outcomes in this ...
14
Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
... cells from the Japanese Collection of Research Bioresources (JCRB), Cell Bank, National Institutes of Biomedical Inno- vation, Health and Nutrition, Japan. No ethical committee approval was required for this set of ...
11
<p>Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma</p>
... The mechanisms of IDH2 regulation and effects on thyroid cancer cell have not been elucidated. According to analysis of the correlations of IDH2 expression with the clinicopathological parameters of the patients, IDH2 ...
13
Aadh2p: an Arxula adeninivorans alcohol dehydrogenase involved in the first step of the 1-butanol degradation pathway
... with 1-butanol with the catalytic efficiency of the purified enzyme being 42 and 43,000 times higher than with ethanol and acetaldehyde, ...or 1-butanol did ...lower 1-butanol consumption if ...
16
Physiological quality and expression of isocitrate lyase enzyme in soybean seeds submitted to saline strress
... This study was conducted at Central Laboratory of Seeds, Department of Agricultural of Universidade Federal de Lavras (UFLA), in Lavras-MG. Were used seeds of soybean cultivars savana, conquista, valiosa, BRS celeste and ...
5
Size and Sequence Polymorphism in the Isocitrate Dehydrogenase Kinase/Phosphatase Gene (aceK) and Flanking Regions in Salmonella enterica and Escherichia coli
... Pattern 3b was found in four B1 strains, among which the extent of overall phylogenetic divergence is sufliciently large to suggest that the pattern has been generated mo[r] ...
12