isolated perfused rat liver
Study of the Biotransformation of Benfluron Using the Isolated Perfused Rat Liver
... The isolated perfused rat liver method (IPRL) was used to find, isolate and identify further metabolites of Phase I and Phase II biotransformation of the potential cytostatic agent benfluron ...
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Synthesis and release of Hageman factor (Factor XII) by the isolated perfused rat liver
... isolated perfused rat liver and have compared rates of synthesis in this system with absolute rates of degradation measured in ...vivo. Rat livers, perfused for 5 h with a ...
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The regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase in the isolated perfused rat liver
... In liver removed during the basal period of the diurnal cycle of enzyme activity, a 227 +/- 41% increase in enzyme activity occurred after 3 h of a plasma-free ...the rat failed to prevent the increase in ...
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DNA SYNTHESIS IN THE ISOLATED PERFUSED RAT LIVER EUR 308 e
... A liverlobe was removed before the second addition of thymidine and at the end of the perfusion 4-5 hours after the start of the perfusion DNA was isolated from the liversamples, and its[r] ...
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Influence of Cl on organic anion transport in short term cultured rat hepatocytes and isolated perfused rat liver
... Transport of 35S-labeled sulfobromophthalein [35S]BSP was studied in short-term cultured rat hepatocytes incubated in bovine serum albumin. At 37 degrees C, initial uptake of [35S]BSP was 5-10-fold that at 4 ...
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Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding
... albumin. Rat liver was perfused with a protein-free fluorocarbon medium, and single-pass uptake of 1, 10, or 200 nmol of [3H]bilirubin was determined after injection as an equimolar complex with ...
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Coordinate pulsatile insulin secretion by chronic intraportally transplanted islets in the isolated perfused rat liver
... studied isolated perfused livers at 10 mM glucose from 27 rats rendered diabetic with streptozotocin and then transplanted with approximately 2 x 10(3) islets, 2 (n = 5), 7 (n = 5), 30 (n = 5), and 200 (n = ...
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Reactive oxygen species during ischemia reflow injury in isolated perfused rat liver
... in isolated perfused livers of male Fischer ...the liver was reperfused for another 60 ...gram liver weight), the biliary efflux of total glutathione ...livers perfused for the same ...
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Biliary secretion of fluid phase markers by the isolated perfused rat liver Role of transcellular vesicular transport
... contribution of transcellular vesicular transport (transcytosis) to the blood-to-bile movement of inert fluid-phase markers of widely varying molecular weight. First, under steady-state conditions, the perfused ...
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Effects of Ranolazine on Carbohydrate Metabolism in the Isolated Perfused Rat Liver
... Since ranolazine inhibits oxygen uptake, it seems reasonable to assume that this also represents diminished mitochondrial ATP production. Corroborating this, a diminution of the ATP content was found in the ...
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Studies on the Pathogenesis of the Ethanol induced Fatty Liver II Effect of Ethanol on Palmitate 1 C14 Metabolism by the Isolated Perfused Rat Liver
... b In the face of Chemical measurements of triglycerides revealed increased mobilization and increased triglyceride that in comparison to control experiments, the formation in the liver, [r] ...
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Synthesis of clotting factors by the isolated perfused rat liver
... The slight shortening of the Factor X assay clotting time is surmised to reflect the absence of Factor X activity in adsorbed rat serum sample 1 and the presence of some Factor X activi[r] ...
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Hepatic processing of transforming growth factor beta in the rat Uptake, metabolism, and biliary excretion
... in liver and/or bile; by 90 min, most of the label removed by the liver (83%) had been slowly excreted into ...the isolated perfused rat liver, which was inhibited by unlabeled ...
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Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis
... the isolated perfused liver of normal rats in the presence of high ...the isolated perfused rat liver, TUDCA (25 microM) stimulated a sustained increase in the ...
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Inhibition of lactate removal by ketone bodies in rat liver Evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism
... into isolated hepatocytes and on lactate removal in the isolated perfused rat ...into isolated hepatocytes (maximum, 35% at concentrations of 10- 20 ...by perfused livers were ...
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Protoporphyrin induced Cholestasis in the Isolated In Situ Perfused Rat Liver
... of liver disease in protoporphyria has been presumed to result from the hepatic deposition of ...an isolated, in situ, rat liver perfusion system. Rat livers in the control group were ...
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Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia
... the isolated, perfused liver the secretion of glutathione and the glutathione conjugate, dinitrophenyl-glutathione (GS-DNP), from hepatocyte to bile is severely impaired, whereas the sinusoidal ...
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Bilirubin Diglucuronide Formation in Intact Rats and in Isolated Gunn Rat Liver
... TABLE IV Bilirubin Monoglucuronide and Diglucuronide Excretion in Bile by Isolated Perfused Gunn Rat Liver after Injection of [3HBilirubin Monoglucuronide during Intrahepatic Unconjugate[r] ...
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Brain natriuretic peptide in pulmonary arterial hypertension: biomarker and potential therapeutic agent
... BNP relaxes preconstricted isolated pulmonary arteries and blunts hypoxic pressor responses in isolated perfused rat lungs with a potency similar to that of ANP (Figure 5). 112 [r] ...
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Potassium transport by the isolated perfused kidney
... kidneys perfused outside of the body with an artificial medium are able to increase their fractional excretion of potassium in response to a rising concentration of potassium in the medium but never show net ...
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