JAK-STAT signaling pathway
Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway
... the JAK-STAT signaling ...the JAK-STAT pathway, we utilized Ruxo, a JAK-STAT-specific inhibitor, to block the pathway and examined the effects of Ruxo on the ...
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Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
... Because JAK/STAT signaling is induced by IL-6, the recorded down-regulation could be attributed to the anti-inflammatory effect of ...this pathway mediates the antifibrotic effect of ...
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Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats
... NF-κB signaling pathway ...inhibited JAK/STAT signaling pathway and regulated chondrocyte cell proliferation and apoptosis ...
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Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6
... that STAT proteins can regulate JAK/STAT signaling pathway related-genes such as STAT5 ...STAT3 signaling pathway, which tar- gets both CCND1 and Bcl-2, led to ...
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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
... the JAK–STAT pathway ...IFN signaling path- way as shown by increasing p-STAT1 levels, up- regulating ISG levels and elevating Interferon sensitive response element (ISRE) ...of ...
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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK STAT signaling pathway
... molecular signaling pathway remains intractable because the potential targets and active substances of herbs are difficult to identify and analyze [37, ...and signaling pathways in FFK treatment were ...
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Hepatitis C Virus-Mediated Enhancement of MicroRNA miR-373 Impairs the JAK/STAT Signaling Pathway
... the JAK/STAT ...counteract JAK/STAT and their downstream signaling events (26, ...including signaling interference, effector modulation, and continuous genetic varia- tion, in ...
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Original Article Mechanism of JAK-STAT signaling pathway inhibitor in post-spinal cord injury
... health. JAK-STAT signaling pathway has been suggested to be involved in the pathogenesis of multiple ...of JAK-STAT in SCI, however, requires fur- ther ...of ...
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Original Article Research of resveratrol regulating JAK/STAT signaling pathway in the treatment of atherosclerotic rats
... The JAK/STAT signaling pathway is an important signal transduction pathway in cells, which is closely related to cellular oxidative stress, inflammatory cytokine secretion, and other ...
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CP690,550 inhibits oncostatin M induced JAK/STAT signaling pathway in rheumatoid synoviocytes
... suppress rheumatoid inflammation and have been thought to be more efficacious than disease-modifying anti-rheumatic drugs (DMARDs) in controlling joint damage [19]. The combination of DMARDs with biolo- gical agents can ...
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Original Article Melatonin attenuates early brain injury after subarachnoid hemorrhage by the JAK-STAT signaling pathway
... Abstract: Increasing studies have demonstrated the neuroprotective effect of melatonin in central nervous system (CNS) diseases. However, the potential application of melatonin in therapy of subarachnoid hemorrhage (SAH) ...
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Herbal formula Xian Fang Huo Ming Yin regulates differentiation of lymphocytes and production of pro inflammatory cytokines in collagen induced arthritis mice
... the JAK/STAT signaling pathway, known as the IL-6 pathway, offers novel potential therapeutic opportunities that aim to prevent bone destruction in RA ...the JAK/STAT ...
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An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans
... the JAK/STAT signaling pathway to induce an antiviral state and mediate viral ...the STAT transcription factors. Upon dimerization, STAT transcription factors can undergo ...
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Original Article Expression of CX43 and SOCS-1 in patients with sudden cardiac death
... CaN pathway, and myocardial hypertrophy may further contribute to ...the JAK/STAT sig- naling pathway and its regulation of the cyto- ...the JAK/STAT signaling ...
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Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation
... that JAK/STAT signaling pathway inhibition by AG490 is involved in regulating apoptotic process in the tubular epithelial cells following I/R insult, the TUNEL staining method was performed ...
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Original Article Mild hypothermia combined with isoflurane post-treatment alleviates cerebral ischemia reperfusion injury in rats through inhibition of STAT3 activation
... activate JAK- STAT signaling pathway in the post-ischemic brain, predominantly in the macrophages/ microglia, and treatment with AG490 (a JAK2 phosphorylation inhibitor) or siRNA specific for ...
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IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis
... gp130/JAK/STAT signaling pathway (Figure 2), making this pathway a potential target for the development of therapeutics that suppress its constitutive and ligand- induced activation ...
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Similarity Analysis of the Immune-Related Genes from Chinese Sturgeon (Acipenser sinensis) and Dabry`s Sturgeon (Acipenser dabryanus)
... comprises signaling as the first line of defense against invasive ...signal pathway analysis to compare the immune-related gene difference in response to ...Many signaling pathways associated with ...
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Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist
... of STAT phosphorylation by ...the JAK-STAT pathway virus-medi- ated inhibition occurs, we examined phosphorylation of STAT1 at Tyr701 (pY-STAT1) by immunoblot analysis of in- fected Vero cell ...
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Modulation of human JAK-STAT pathway signaling by functionally conserved regulators
... with STAT-modulator phenotypes suggests that most siRNA pools are indeed ...both STAT phosphorylation and transcriptional activity have been widely used as proxies for pathway activity in the past, ...
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