JAK/STAT3 pathway
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL 11–JAK/STAT3 pathway
... In this study using previously unchar- acterized PJS models we demonstrate that loss of Lkb1 in stroma leads to (a) clonal expansion of stromal cells and (b) activation of an inflammatory pro- gram involving the ...
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Inhibition of Jak STAT3 pathway enhances bufalin induced apoptosis in colon cancer SW620 cells
... by STAT3 inhibition ...μmol/L Jak-STAT3 pathway inhibitor AG490 for 1 h, and then exposed to bufalin, the down-regulation of livin protein expression and activation of caspase-3 were enhanced, ...
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Original Article Long non-coding RNA P4713 contributes to the malignant phenotypes of oral squamous cell carcinoma by activating the JAK/STAT3 pathway
... (KEGG) pathway analysis showed that the P4713-associated mRNAs were mainly involved in adhesion, motility, JAK/STAT signal- ing, and pathways in cancer (Figure 4C, ...and STAT3 were downregulated ...
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Anti tumor and anti angiogenic effects of Fucoidan on prostate cancer: possible JAK STAT3 pathway
... Fucoidan is a sulfated polysaccharide obtained mainly in various species of brown algae and brown seaweed such as Undaria pinnatifida, Laminaria angustata, Fucus vesiculosus, and Fucus evanescens [14, 15]. It is reported ...
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OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway
... Chronic urticaria (CU), an immune-mediated inflamma- tory disease, is defined as the spontaneous or inducible ap- pearance of hives, angioedema or both lasting at least 6 weeks and presenting with numerous subtypes, all ...
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Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo
... (STAT) pathway is one of them [8,9]. Activation of this pathway involves cytokine activation of its receptor, subsequent tyrosine phosphorylation of intracellular JAK kinases, then recruitment and ...
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Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... IL-6/JAK/ STAT3 pathway and GCa risk with a relatively large sample ...the pathway and may have missed some important, truly functional ...
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Original Article IL-6 improves myogenesis in long-term skeletal muscle atrophy via the JAK/STAT3 signalling pathway
... Abstract: Objectives: To investigate the roles of macrophages and interleukin-6 (IL-6) in the regeneration of atrophic muscles. Results: In vitro, Satellite cells (SCs) cultured with DMEM, IL-6, IL-6+AG490, which is an ...
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Original Article Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium
... the STAT3 expression in cholesteatoma has been carried ...of STAT3 in cholesteatoma tis- sues and EAC skin, and discovered an obvious- ly increased expression of p-STAT3 in choleste- atoma tissues as ...
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STATus and Context within the Mammalian Nervous System
... LIF-mediated Stat3 activation is mirrored by BDNF, but not NT4, and is mediated by a serine kinase ...include Stat3, JUN, ATF3 and ...active Stat3 served as a pow- erful cue for neurite extension ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... (JAK/STAT) pathway is a stress- responsive mechanism that has been implicat- ed in variety of cardiac pathophysiologic pro- cesses including hypertrophy, apoptosis, oxida- tive stress, myocardial ...
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miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma
... inhibiting JAK kinase activity and STATs binding to cytokine receptors, and facilitating proteaso- mal degradation of JAK ...the JAK/STAT3 ...of STAT3 signaling pathway ...
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LNK promotes the growth and metastasis of triple negative breast cancer via activating JAK/STAT3 and ERK1/2 pathway
... signaling pathway of hematopoi- etic receptors activated by growth factors, thus playing a critical role in hematopoiesis [11–13] ...JAK2/STAT3 pathway and lymphoid proliferation in vivo and, above ...
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Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
... SH2-containing protein (CIS). SOCS proteins are cyto- kine-induced negative feedback-loop regulators of JAK- STAT signaling. Each member protein in this family has a central SH2 domain, variable amino-terminal ...
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Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNα
... of STAT3 and STAT1) or 48 h (to detect the activation of ERK) and then lyzed in 100 µL lysis buffer (10 mM Tris-Cl pH ...anti-ERK, STAT3, STAT1 or anti-phospho-ERK, phospho-STAT3, phospho-STAT1 an- ...
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The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
... STAT pathway components also have effects on gene expression outside the ‘canonical’ signalling phosphorylation cascade, by contributing to epigenetic modifications of ...function. STAT3 can localise to the ...
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Stat3 accelerates Myc induced tumor formation while reducing growth rate in a mouse model of breast cancer
... of Stat3 in different oncogene-driven tumors, we compared gene expression profiles of MMTV-Myc and MMTV-Neu ...the Stat3 pathway [21] were ...of Stat3 pathway genes and were used in ...
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Methotrexate Is a JAK/STAT Pathway Inhibitor
... suppresses JAK/STAT signalling and suggest that this suppression may explain the effectiveness of low-dose methotrexate treat- ments currently used as a first line treatment for inflammatory diseases such as ...
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STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
... Fig. 4. Effects of STAT3 inhibitor on OSM-induced MMP-2 and MMP-9 enzymatic activities and invasion activity. On the gelatinolytic zymography, OSM- induced MMP-2 and MMP-9 enzymatic activities were significantly ...
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Factors Associated with Smoking Behaviors among Military Cadets of King Khalid Military Academy (KKMA), Riyadh, Saudi Arabia (2015-2016)
... control, stat3, Spring Bioscience source at a dilution of 1:200 with breast carcinoma as a positive control and for bcl-2, Spring bioscience sourceSP66 clone at a dilution of 1:400 with tonsil as a positive ...
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