JAK2/STAT3
Original Article Effects of fallopian tube recuperation soup on JAK2/STAT3 pathways in rats with tubal infertility
... Western blotting was carried out, as described previously [14]. Briefly, oviduct tissues were lysed in RIPA buffer (50 mM Tris-HCl, 150 mM NaCl, 1% NP-40, and 0.1% SDS; pH 8.0) supple- mented with a protease inhibitor ...
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Original Article JAK2/STAT3 is associated with the inflammatory process in periapical granuloma
... the JAK2/STAT3 path- way, which contributes to their immunoregula- tory and inflammatory properties ...[12]. STAT3 participates in inflammatory disease, such as periodontitis, head and neck cancer, ...
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microRNA 146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling
... In this research, we investigated the effects of miR-146a on childhood AL and its related molecular mechanisms. Our re- sults suggested that miR-146a could promote the prolifera- tion, migration, and invasion of Jurkat ...
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CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells
... At present, the mechanisms involved in cisplatin resistance are not yet fully understood, because the research in platinum drug resistance is limited. Inhibition of apoptosis and cellular proliferation are important ...
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Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/ STAT3
... Icaritin is an active prenylflavonoid derived from Epimedium genus, a traditional Chinese medicine. Icaritin has a wide range of pharmacological and biological activities, including cardiovascular function improvement, ...
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Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
... Next, we investigated the autophagy and JAK2/STAT3 pathway in xenograft tumors. IHC was used to evaluate VEGFA, CD34 and proliferation marker Ki67 in tumor tissues. Anlotinib plus CQ treatments most ...
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<p>STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway</p>
... and p-STAT3. Moreover, E-cadherin expression in the tumors of nude mice injected with STIP1 shRNA- transfected A549 cells was signi fi cantly higher (P<0.05, Figure 5F) than that of nude mice injected with ...
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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
... sustains JAK2 activation via blockage of JH2-mediated autoinhi- bition of ...JH2-mediated JAK2 inhibition (26, ...induced JAK2 kinase activity via inhibition of JH2 ...recombinant STAT3 with ...
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Original Article MicroRNA-30b targets CBX3 and regulates cell proliferation, apoptosis, and migration in esophageal squamous cell carcinoma via the JAK2/STAT3 signaling pathway
... the JAK2/STAT3 signaling pathway was investigat- ...the JAK2/STAT3 signaling pathway widely occurs with high frequency in ESCC and disruption of this pathway can repress the tumorigenesis and ...
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Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway
... that JAK2-STAT3 signaling pathway can be directly reg- ulated by miR-337-3p, we co-transfected miR-337-3p with or without miR-337-3p inhibitor, as indicated, the presence of miR-337-3p inhibitor completely ...
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A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma
... [20,21], JAK2/Stat3 was identified as the target of ...that JAK2/Stat3 was strongly upregulated at both RNA and protein levels (Figure 4A and Figure ...downregulated JAK2/Stat3 ...
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Original Article Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
... of STAT3 signal related ...in JAK2/STAT3 signaling, while MMP- 2 and MMP-9 proteins levels were decreased and protein expression of VEGF and VEGFR-2 were ...in JAK2/ STAT3-dependent ...
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Bacterial Lipopolysaccharide Vigorously Activate JAK2/STAT3 Induced Rheumatoid Arthritis Collate with Complete Freund's Adjuvant in Experimental Rats
... on JAK2/STAT3-induced RA, compared to the traditional Complete Freund’s Adjuvant (CFA)-induced ...phosphorylated JAK2 and STAT3, while serum samples used for biochemical evaluation of ...
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IL 17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
... of JAK2 and STAT3. It has been shown that modulation of JAK2/ STAT3 by IL-17A could play a critical role in osteoblast differentiation proceed with qPCR result ...of JAK2/STAT3 ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... The JAK2/STAT3 pathway was activated in cerulein-induced AP rats’ pancreatic acinar ...of JAK2/STAT3 signaling pathway in humans with acute pancreatitis (AP) is yet ...with ...
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The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
... intrinsic JAK2 expression was elevated by RT, consequently leading to STAT3 activation and collectively limiting RT-induced apoptosis and enhancing the clono- genic potential of cells surviving RT ...that ...
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ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway
... of STAT3 and p-STAT3 in the cancer tissues obtained from DLBCL ...activates JAK2/STAT3 ...the JAK2/STAT3 inhibitor WP1066 resumed the CHOP cytotoxicity suppressed by ALDH1A1 ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... ticularly JAK2/STAT3 signaling, plays a vital ro- le in mediating cardioprotection against isch- emia/reperfusion (I/R) injury ...of JAK2/STAT3 acti- vation in MI/R injury is still incomplete ...
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Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... of JAK2/STAT3 by inducing c-Src- JAK2 complex ...to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased total JAK2 and STAT3 levels, which ...
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Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres
... analysis STAT3 was the specific gene of interest. We analyzed STAT3 gene expression level with respect to GBM in 538 subjects, and survival analysis was censored by survival months, which means that even ...
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