JAK2-STAT3 pathway
ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway
... of STAT3 and p-STAT3 in the cancer tissues obtained from DLBCL ...activates JAK2/STAT3 ...the JAK2/STAT3 inhibitor WP1066 resumed the CHOP cytotoxicity suppressed by ALDH1A1 ...
12
Original Article IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2/STAT3 pathway
... that STAT3 signaling pathway has been involved in the pathogenesis of liver fibrosis, cirrhosis and ...of STAT3 has been implicated in the proliferation and metastasis of liver can- cer cells [21, ...
7
Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway
... a Jak2/STAT3 inhibitor, restored the expression of DC markers and costimulatory ...of Jak2/STAT3 pathway, and there may be different mechanisms by which adriamycin-resistant BCC ...
11
Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... (JAK/STAT) pathway plays a vital role in mediating cardioprotection against ischemia/ reperfusion (I/R) ...the JAK2/STAT3 pathway in the cardioprotective effects of PNS during ...
11
Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke
... endothelial cells. SN-mediated neuroprotection rescued primary cortical cell cultures from oxygen/glucose deprivation. SN also induced expression of the antiapoptotic proteins Bcl-2 and Bcl-xL through the ...
17
Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
... a JAK2 inhibitor and one of the hits from the screen, repressed survival of BCL6- deficient cells in vitro and reduced growth and proliferation of xenografts in ...induced JAK2 mRNA and protein expression ...
14
Original Article JAK2/STAT3 pathway mediating inflammatory responses in heatstroke-induced rats
... of JAK2 inhibitor AG490 on the brain injury and inflammatory responses of rats with systemic ...the JAK2 inhibitor AG490 was significantly attenuated the brain injury and inflammatory responses induced by ...
8
Original Article The JAK2/STAT3 pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats
... JAK-STAT pathway, which includes a family of JAKs that activate STATs, can be activated by ischemic injury ...that STAT3 phosphorylation is up-regulated after focal cerebral ischemia in rodents ...blocking ...
7
The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells
... tical pathway that plays an important regulatory role in microglial reactivity to various stimuli, including cere- bral ischemia, gangliosides, lipopolysaccharide, thrombin and cytokines ...JAK-STAT3 ...
13
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
... that JAK2/STAT3 are involved in tumor angiogenesis, particularly in the regulation of ...of JAK2/STAT3 pathway in mediating VEGF expression upon Ginkgolide K treatment after ischemic ...
13
Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... the JAK2/STAT3 pathway, we assessed IL-6-induced JAK2 and STAT3 activation in MBA-MB-231 and Hs578T control-shRNA or TrkB-shRNA ...of JAK2/STAT3, as well as Twist-1 ...
14
Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... The present study evaluated the severity of the disease with enhanced CT or MRI per- formed in 5-7 days. The MCTSI score < 4 divid- ed into the mild subgroup, and MCTSI score ≥ 4 into the severe subgroup. This study ...
7
Original Article Protective effect of apigenin against myocardium injury in ischemia reperfusion rats by stimulating JAK2/STAT3 signal pathway
... of JAK2-STAT3 pathway in Api-induced ...of STAT3 or dele- tion of STAT3 appears to be a key event in the diminution of cardioprotection in response to various physiological stresses ...
7
Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
... of JAK2 and STAT3 proteins in the hippocampus of rats 2 hours after ...the JAK2–STAT3 pathway plays an important role in the neuroprotective effects of dexmedetomidine following brain ...
13
Original Article Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
... Salidroside has been reported to have many kinds of pharmacological effects in both in vivo and in vitro experimental models. In the pres- ent study, salidroside was found to show anti- cancer effects on colon cancer ...
7
Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer ...the pathway and GCa risk in a study of 1,125 GCa cases and 1,221 cancer-free ...with STAT3 ...
12
Original Article Effects of fallopian tube recuperation soup on JAK2/STAT3 pathways in rats with tubal infertility
... on JAK2/STAT3 pathways in rats with salpingitis-induced ...of JAK2 and STAT3 mRNA in oviduct tissues were detected by ...of JAK2, STAT3, phosphorylat- ed JAK2 ...
9
The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
... of JAK2 was significantly increased after RT in all tested CRC cells, including patient-derived primary CRC cells and human CRC cell lines, while the in- crease in ATM transcription was statistically significant ...
18
<p>Self-Renewal Signalling Pathway Inhibitors: Perspectives on Therapeutic Approaches for Cancer Stem Cells</p>
... Hh pathway that binds to Smo and inhibits abnormal activation of the Hh ...Hh pathway and received US Food and Drug Administration (FDA) approval for treatment of advanced basal cell carcinoma ...
16
Original Article Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in bladder cancer
... the JAK-STAT pathway, leading to cell growth and survival. He et al. [36] had demonstrated that hypermethylation of the SOCS3 promoter region also correlated with silencing of SOCS3 in breast cancer and ...
9