JAK2-STAT3 signaling
Original Article MicroRNA-30b targets CBX3 and regulates cell proliferation, apoptosis, and migration in esophageal squamous cell carcinoma via the JAK2/STAT3 signaling pathway
... Abstract: The present study aimed to investigate whether miR-30b plays a pivotal role in the progression of esopha- geal squamous cell carcinoma (ESCC) as well as to elucidate its possible regulatory mechanism. The ...
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S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells
... of JAK2/STAT3 signaling ...of JAK2/STAT3 signaling ...Thus, JAK2/STAT3 signaling pathway may contribute to H 2 S- induced cell proliferation, anti-apoptosis, ...
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An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway
... activated JAK2-STAT3 signaling pathway is a high risk factor for multiple myeloma (MM), a fatal malignancy of plasma ...a STAT3-targeted drug screen. SC09 suppressed the activation of ...
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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
... of JAK2/STAT3 signaling under physiological ...within JAK2, which abrogate the function of JH2 and sustain JAK2 activation, are widely observed in hematological malignancies, comparable ...
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Original Article Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
... Salidroside has been reported to have many kinds of pharmacological effects in both in vivo and in vitro experimental models. In the pres- ent study, salidroside was found to show anti- cancer effects on colon cancer ...
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<p>STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway</p>
... and signaling pathways associated with EMT are complex and variable. The JAK2/STAT3 signaling pathway is known to regulate epithelial cell – cell adhesion and is closely related to the ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... The JAK2/STAT3 signaling pathway is induced by their proteins phosphoryla- ...that JAK2/STAT3 signaling path- way is activated in AP ...the JAK2/STAT3 pathway [20, ...
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CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells
... Immunohistochemical staining for CXCL12 and p-STAT3 was performed using the standard streptavidin–peroxidase biotin technique (SP technique) with an SP kit (Zhongshan Co., Beijing, China). Paraffin sections (4 μ ...
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The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
... validation, Stat3 activity, immunofluorescence, immunohistochemistry, immunoblots, and flow ...Cell Signaling), Stat3 (sc-482; Santa Cruz Biotechnology ...Cell Signaling), tubulin (T-5168; ...
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<p>Electroacupuncture treatment upregulates α7nAChR and inhibits JAK2/STAT3 in dorsal root ganglion of rat with spared nerve injury</p>
... and JAK2/STAT3 signaling on 2 Hz EA reliev- ing SNI-induced neuropathic pain in the ...of JAK2/STAT3, pro- in fl ammatory cytokines IL-1 β and IL-6 levels in the ...of ...
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Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... of JAK2/STAT3 by inducing c-Src- JAK2 complex ...to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased total JAK2 and STAT3 levels, which ...
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<p>Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation</p>
... known STAT3 inhibitor as a comparison to further investigate the inhibi- tory effect of CTS and structurally similar compounds on the STAT3 ...the JAK2/STAT3 signaling pathway, ...
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Scutellarin protects human retinal pigment epithelial cells against hydrogen peroxide (H2O2)-induced oxidative damage
... of JAK2/STAT3 signaling ...the JAK2/STAT3 signaling pathway ...a STAT3 signal pathway ...enhancing JAK2/STAT3 pro-survival signaling ...the ...
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ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway
... of STAT3 and p-STAT3 in the cancer tissues obtained from DLBCL ...activates JAK2/STAT3 ...the JAK2/STAT3 inhibitor WP1066 resumed the CHOP cytotoxicity suppressed by ALDH1A1 ...
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JAK2 binding long noncoding RNA promotes breast cancer brain metastasis
... phosphorylates STAT3, which promotes tumorigenesis and progression in a wide range of tumor types ...that JAK2/STAT3 signaling is hyperactivated in brain metastatic breast cancers and that ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... A growing number of studies have intensively investigated reactive oxygen species (ROS) to reveal their role in MI/R injury, ranging from beneficial to inimical [39, 40]. When the bal- ance between the production and ...
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The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
... JAK/STAT signaling path- way was activated in residual CRC tissues after RT and that this activation was associated with metasta- sis in CRC tissues, which is the most destructive consequence resulting from ...
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Bacterial Lipopolysaccharide Vigorously Activate JAK2/STAT3 Induced Rheumatoid Arthritis Collate with Complete Freund's Adjuvant in Experimental Rats
... of signaling pathways that mediate rheumatoid arthritis (RA) ...on JAK2/STAT3-induced RA, compared to the traditional Complete Freund’s Adjuvant (CFA)-induced ...phosphorylated JAK2 and ...
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Original Article Effects of fallopian tube recuperation soup on JAK2/STAT3 pathways in rats with tubal infertility
... on JAK2/STAT3 pathways in rats with salpingitis-induced ...of JAK2 and STAT3 mRNA in oviduct tissues were detected by ...of JAK2, STAT3, phosphorylat- ed JAK2 ...
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HSP90 is a therapeutic target in JAK2 dependent myeloproliferative neoplasms in mice and humans
... wild-type JAK2 are degraded by PU-H71, the basis for the selective effects of PU-H71 on MPN is likely not due to increased affinity of PU-H71 for mutant/active ...specific JAK2 degradation, without ...
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