Janus kinase
Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor
... of Janus kinase 2 (JAK2), JAK2V617F, and fms-like receptor tyrosine kinase 3, is in Phase III development in ...receptor-associated kinase 1 achieved half-maximal inhibitory concentrations ...
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In silico docking analysis of Janus kinase enzymes and phytochemicals
... approach. Janus kinase is a key enzyme in the JAK - STAT pathway leading to various inflammatory ...and Janus kinase enzymes (JAK 1, 2 and 3) using the Patchdock docking ...
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Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
... tyrosine kinase Janus kinase 3 (JAK3), an enzyme that is asso- ciated with the common gamma chain (γc) of various cytokine receptors and is critical for signal transduction by interleukin (IL)-2, -7, ...
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Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor negative breast cancer via Src family kinase mediated, janus kinase 2 independent pathway
... for Janus kinase (JAK) binding and ...JAK2 kinase, where JAK2- independent responses appear to be mediated by mem- bers of the src family kinases (SFKs) ...
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Splenomegaly in myelofibrosis—new options for therapy and the therapeutic potential of Janus kinase 2 inhibitors
... activating Janus kinase 2 (JAK2) activating mutation (JAK2V617F) that is present in almost all patients with PV and in about 50-60 % of patients with ET and PMF led to the initiation of several trials ...
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Role of janus kinase inhibitors in the treatment of alopecia areata
... receptor, janus kinase (JAK), and signal transducer and activator of transcription (STAT) (Figure ...tyrosine kinase family, which consists of JAK1, JAK2, JAK3, and tyrosine kinase 2 ...
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Tofacitinib, an oral janus kinase inhibitor: pooled efficacy and safety analyses in an Australian rheumatoid arthritis population
... Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. The efficacy and safety of tofacitinib 5 and 10 mg twice daily (BID), administered as monotherapy or in combina- tion with csDMARDs ...
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Stat3 is tyrosine phosphorylated through the interleukin 6/glycoprotein 130/Janus kinase pathway in breast cancer
... tyrosine kinase, leading to the prediction that its phosphorylation in breast cancer would be through these multiple, redundantly acting growth factors [6- ...130/Janus kinase (gp130/Jak) pathway, is ...
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Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells
... TG101348 overcame the HS-5-mediated protection of K562 cells (Figure 2A). Using immunoblotting, we deter- mined that phosphorylation of Crk-L, a BCR-ABL sub- strate, STAT5, and mitogen activated protein kinase ...
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A highly selective, orally active inhibitor of Janus kinase 2, CEP 33779, ablates disease in two mouse models of rheumatoid arthritis
... Using small molecules to target cytokine pathways is an attractive method to treat disease simply because of the oral bioavailability of small molecules and the reduced cost of production, thus reducing the cost car- ...
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<p>Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo</p>
... Notes: ( A ) Nucleocytoplasmic JAK1 expression in epidermis in control skin; ( B ) cytoplasmic expression of JAK1 in eccrine and sweat-gland ducts in control skin; ( C ) Epidermal cytopl[r] ...
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Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction
... tyrosine kinase called Hopscotch (Hop; B inari and P errimon 1994) bearing 27% identity to human JAK2 and a single STAT-like transcription factor, STAT92E (also known as Marelle; H ou et ...
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A role for type 111 interferons in the natural killer cell immune response to virus
... IFN stimulated gene IFN stimulated gene factor IFN stimulated response elements Immunoreceptor tyrosine-based inhibitory motif Janus kinase Killer immunoglobulin -like receptor Lymphokin[r] ...
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Checkpoint inhibitors in hematological malignancies
... JAK/STAT: Janus kinase/ signal transducer and activator of transcription; JNK: c-Jun NH2-terminal kinase; KO: Knock-out; LAG-3: Lymphocyte activation gene 3; LMP1: EBV latent membrane protein 1; ...
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Biologically inactive growth hormone caused by an amino acid substitution
... GHR, janus kinase 2 (JAK2), and signal transducers and activators of transcription 5 (STAT5) in IM-9 cells was detected by Western blotting as described previously, with modifications (9, 15, ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: low‑density lipoprotein; LpL: lipoprotein lipase; LPS: lipopolysac‑ charide; MA: ...
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Sphingosine 1-Phosphate-Metabolizing Enzymes Control Influenza Virus Propagation and Viral Cytopathogenicity
... signal-regulated kinase (ERK) and STAT1 but not of p38 mitogen-activated protein kinase (MAPK), Akt, or c-Jun N-terminal kinase ...of Janus kinase (JAK) activity elevated the level of ...
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Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
... through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stably expressing the GH recep- tor (293GHR), HuH7 (hepatoma) and T-47D (breast cancer) ...
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Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin 1
... mmol/l]), janus kinase (JAK)2 (tyrphostin AG490 and Tkip), phosphatidylinositol 3-kinase (PI3K; wortmannin [1, ...protein kinase kinase (MEK)1 (PD098059 [1, 5, 10, 20 and 30 µmol/l]) ...
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Complementary genetic and functional analyses of genes involved in adiposity
... Janus kinase kilobase kilodalton Leptin binding assay human leptin gene mouse leptin gene human leptin receptor gene mouse leptin receptor gene Leukaemia inhibitory factor Lipopolysaccha[r] ...
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