JNK activation
JNK activation is responsible for mucus overproduction in smoke inhalation injury
... Since smoke inhalation during fires is associated with mucus hypersecretion, we evaluated mucin secretion in the airway of mice by using the PAS stain. The PAS stain is mainly used for staining structures containing a ...
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The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells
... JNK activation may exert viral-supportive or antiviral effect for diverse ...example, JNK knockout mouse embryonic fibroblasts (MEF) were more suscep- tible to oncolytic vaccinia virus infection than ...
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Proper closure of the optic fissure requires ephrin A5 EphB2 JNK signaling
... contrast, JNK is significantly activated in EphB2-expressing cells exposed to 1-2 h of ephrin A5 treatment, but short-term ephrin A5 treatment ...activate JNK. We show that JNK is highly activated in ...
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Sustained Activation of Mitogen-Activated Protein Kinases and Activator Protein 1 by the Hepatitis B Virus X Protein in Mouse Hepatocytes In Vivo
... Transcriptional activation of diverse cellular genes by the X protein (HBx) of hepatitis B virus (HBV) has been suggested as one of the mechanisms for HBV-associated hepatocellular ...ERK activation ...
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Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium.
... that JNK signalling is a medi- ator of gap junctional remodelling during progressive ageing of the right atria by a mechanism that could account for the observed dynamic changes in Cx43 protein ...expression. ...
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JNK suppresses pulmonary fibroblast elastogenesis during alveolar development
... 3 JNK activation and elastogenesis are inversely ...By JNK pull down assay, JNK activity (c-Jun phosphorylation) was increased during saccular (PND1&3) and alveolar (PND9&14) stages of ...
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Herpes Simplex Virus ICP27 Activation of Stress Kinases JNK and p38
... slight activation of p38 in the mock-infected samples as a function of increasing temperature (lanes 1 to ...or JNK and for protein loading ( ␣ -tubulin) before calculating the reduction in ...
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<p>Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation</p>
... activated JNK is associated with cell survival, sustained JNK activation induces apoptosis, 47 and chemoresistance is acquired through autophagy mediated by JNK and mTOR ...of JNK in ...
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c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... Tissue array method was used in the present study to evaluate the clinical significance of JNK activation and its association with FOXO1 inactivation. The potential limi- tations of tissue array method are ...
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Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation
... Notably, activation of JNK signaling in the setting of cellular stress is a key feature of the first phase of HSV ...reactivation. JNK activation in neurons results in a histone methyl/phospho ...
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Apical deficiency triggers JNK dependent apoptosis in the embryonic epidermis of Drosophila
... the activation of JNK signalling by loss of apical determinants remains ...modulates JNK signalling (path 1, blue arrow in ...on JNK signalling is mediated by junctional disruption (path 2, ...
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The MEKK1 JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
... increased JNK activity in Mekk1 +/+ but not Mekk1 –/– mice, indicating that MEKK1 mediates JNK activation by pressure ...overload–induced JNK activation and cytokine upregulation but to ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... of JNK is oxida- tion stress and the increase of oxygen-free radi- cals (ROS) level (Levkovitz et ...activating JNK and the subsequent release of cytochrome c from mitochondria, but also through endoplasmic ...
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Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
... The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that regulate many cellular processes central to kidney fibrogenesis including cell proliferation, apoptosis, EMT and ECM deposition ...
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PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
... abnormal activation of the immune system leading to stimulation of ...contrast, activation of JNK and NF-κB was not affected by U73122 or Dap12/FcRγ ...
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Bikunin Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Induction in Macrophages
... the JNK and p38 MAP kinase pathways, which relieve AU-rich element-dependent posttranscriptional repres- sion, resulting in enhanced TNF- ␣ mRNA stability and trans- lation ...to activation of the ERK1/2 ...
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Original Article 10% HA/SPEEK/PEEK composite promotes proliferation and differentiation of osteoblast cells through the MAPK and PI3K/AKT signaling pathways
... phosphorylated JNK (p-JNK), P38, phosphorylated P38 (p-P38), phosphorylated phosphatidylinositol 3-kinase (p-PI3K) (1:500, Bioss, Beijing, China), PI3K (1:400, Boster, Wuhan, China), protein kinase B (AKT), ...
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Original Article Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis
... effective against 2, 4, 6-trinitrobenzene sulfon- ic acid (TNBS)-induced colitis in mice as mani- fested by the improved weight loss and histo- logical scores [12]. Typically, SIN is capable of inhibiting lymphocyte ...
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Mixtures of xenoestrogens disrupt estradiol-induced non-genomic signaling and downstream functions in pituitary cells
... and JNK across a wide range of concentrations and times ...MAPK activation, decreasing as concentrations ...pathway activation; 2) receptor down- regulation or desensitization; 3) the presence of ...
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Original Article Puerariae radix flavone induces cell cycle arrest and apoptosis of NB4 cells accompanied with JNK and mitochondrial pathway activation
... of JNK, where-as the expression of p-ERK increased only after treatment with 10 μg/ml PRF, and p-p38 was not affected by PRF (Figure ...the JNK upstream protein SEK/MKK4 and downstream protein ...to ...
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