JNK and p38-MAPK
Original Article Paeoniflorin inhibits PDGF-BB induced pulmonary arterial smooth muscle cells proliferation via p38 MAPK/JNK pathways and alleviate inflammation
... of JNK and p38 MAPK in human umbilical vein endothelial cells ...of p38 MAPK/JNK in PDGF-BB induced PASMCs, and that ERK1/2 was not ...
8
Original Article Electroacupuncture promotes locomotor recovery by inhibiting the activation of JNK and p38 MAPK signaling pathways in spinal cord injury rats
... p-JNK. p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress found in eukaryotic cells from yeast to mammals ...[42]. p38 MAPK pathway signaling is known to ...
11
Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK Dependent ROS
... the MAPK pathways and caspase cas- cade to evaluate the molecular mechanism involved and cellular targets of plasma using Western ...phosphor- p38, and caspase-3, but not phosphor-ERK, were increased after ...
8
Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways
... of JNK and p38 MAPK pathways in Querectin mediated apoptosis of Y79 RB ...of JNK and p38 MAPK in cancerous Y79 ...with JNK and p38 MAPK inhibitor leading to ...
8
Interleukin-1β regulates the expression of glucocorticoid receptor isoforms in nasal polyps in vitro via p38 MAPK and JNK signal transduction pathways
... of p38 MAPK and JNK pathways in the regulation of GR isoform ...3: JNK-specific inhibitor (SP600125) decreased the expressions of GR isoforms and phospho-JNK, but not that of phospho-p ...
10
Original Article Xanthotoxol inhibits cerebral ischemia/reperfusion injury-induced hippocampal neuronal cell apoptosis through suppressing the p38 MAPK and JNK signaling pathways
... of p38 MAPK changes in ischemic brain tissue and that inhibition of the p38 MAPK activation can provide protection in a variety of in vitro and in vivo models of brain injury by prevention of ...
8
Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression
... or p38 also function independently in ZDHHC17-expressing glioma ...for JNK activation, as a p38 agonist or p-p38 inhibitor did not respectively counteract ZDHHC17 depletion-induced disruption ...
18
Surface-exposed loops L7 and L8 of Haemophilus (Glaesserella) parasuis OmpP2 contribute to the expression of proinflammatory cytokines in porcine alveolar macrophages
... In gram-negative bacteria, the ability to cause infec- tions is partly attributed to the antigenic variability in all surface-exposed loops of OMPs, and these loops also play a key role in regulating both innate and ...
11
JNK and p38 Mitogen-Activated Protein Kinase Pathways Contribute to Porcine Circovirus Type 2 Infection
... the JNK and p38 MAPK cellular stress pathways (28, 48, ...of JNK and p38 MAPK, which are responsible for inducing apoptotic cell death ...of JNK and p38 pathways ...
9
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction
... Three MAPK subfamilies have been well characterized: extracellular signal regulated kinase 1 and 2 (ERK1/2), c-jun N-terminal kinases (JNK) and p38-MAPK ...while p38-MAPK and ...
13
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas
... Osteosarcomas, the most common malignant bone tumors, show a potent capacity for local invasion and pulmonary metastasis. Resveratrol (RESV), a phytochemical, exhibits multiple tumor-suppressing activities and has been ...
18
Modulation of interleukin 1β induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR 1002, in synovial fibroblasts
... of JNK and p38 MAPK (Figure 4) and NF-B (Figure 5) signaling ...the JNK and NF-B pathways (Additional file 1, Table ...IL-1b-induced JNK and p38 MAPK activity in human FLS ...
14
12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... excessive MAPK phos- phorylation in mouse and cell culture models of diabetic ...and p38 MAPK, ERK, and SAPK/JNK phosphorylation (all by Western blot analysis) were increased in the peripheral ...
10
Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
... the p38-MAPK dependent activation of caspase-3 which in turn, was associated with α-actin ...ERK1-, JNK-2, or any of the p38-MAPKs (Fig- ures 2, 3, and ...and JNK-2-MAPK proteins ...
11
Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L
... of p38 and JNK in response to dsRNA transfection or vaccinia virus infection in an IPS-1-dependent manner? One possibility is through protein-protein interaction with an RLR signal trans- duction pathway ...
8
Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death
... Next we used the pharmacological inhibitors to understand the roles of signaling protein kinases in NaIO3-induced cytotoxicity. As shown in Fig. 5a, SB203580 and SP600125 can partially protect cells against NaIO3-induced ...
11
ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... Bax, JNK, ERK1/2, PARP, p38 MAPK, phosphor-JNK, phosphor-ERK1/2, phosphor- p38 MAPK, cleaved caspase-3, and β-actin in whole cell lysates were analyzed by sodium dodecyl sulfate ...
12
Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis
... The reaction was terminated by adding 1 mL of cold PBS, which contained 100 μM sodium vanadate. The samples were then placed on ice, washed with ice-cold PBS, and lysed in RIPA lysis buffer for 30 mins. Lysates were ...
9
Murine Coronavirus Replication-Induced p38 Mitogen-Activated Protein Kinase Activation Promotes Interleukin-6 Production and Virus Replication in Cultured Cells
... both p38 MAPK and JNK/SAPK pathways but not the activation of ERK1/2, a third member of the major MAPK pathways, sug- gesting that only the SAPKs were activated in MHV-infected ...of ...
12
Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
... of MAPK, JNK, p38 and ERK. Among MAPK members, JNK and p38 are activated in response to various intrin- sic and extrinsic stresses [21, ...activated p38 MAPK may ...
13