JNK signaling
JNK-signaling: A multiplexing hub in programmed cell death
... pyroptotic signaling pathway, the inflammatory stimuli lead to the direct activation of ...pyroptotic signaling pathway, the inflammatory agents such as bacterial lipopolysaccharides activate caspase ...
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Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila
... Our data provides evidence to add Odd to the growing list of proteins directly or indirectly involved in thorax closure. Further analysis is required both at the loss- and gain-of-function levels and also in identifying ...
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JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites
... Studies in various model systems have shown that Wnt5 can bind to different receptors, including Frizzled, Ror2, CD146 and RYK, to activate JNK (Kumawat and Gosens, 2016; Fradkin et al., 2010; Nishita et al., ...
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Original Article Effect of FGFR2IIIc S252W overexpression upon osteosarcoma U2OS cell proliferation via activating ERK1/2 and JNK signaling pathways
... ERK1/2 signaling pathway. The acti- vation of JNK pathway was also observed, which was not found in previous ...of JNK MAPK pathway because the JNK signaling pathway was associated with ...
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Original Article Activation of c-Jun/JNK signaling predicts poor prognosis in nasopharyngeal carcinoma
... c-Jun/JNK signaling pathways with clinical features of NPC, immu- nohistochemistry staining was used to mea- sure c-Jun, JNK, p-c-Jun, and p-JNK protein ...c-Jun, JNK, p-c-Jun, and ...
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<p>The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance</p>
... insulin signaling pathway, then attenuate glucose uptake and subsequent disposal mediated by insulin, and increase produc- tion and output of ...activates JNK and NF- κ B signaling pathways. With the ...
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Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway
... Moreover, JNK signaling was stimulated by AA, and the stimulation was partially reversed by a JNK signaling inhibitor in accordance with cell cycle-related ...the JNK signaling ...
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JNK signaling regulates E cadherin junctions in germline cysts and determines primordial follicle formation in mice
... and JNK signaling coordinate germline cyst ...of JNK and WNT4 signaling function in cyst breakdown and primordial follicle ...Then, JNK signaling showed an uptrend, while the ...
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Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling
... Objectives: Oncogenic potential of Notch signaling and its cooperation with other factors to affect proliferation are widely established. Notch exhibits a cooperative effect with loss of a cell polarity gene, ...
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Portulacerebroside A inhibits adhesion, migration, and invasion of human leukemia HL60 cells and U937 cells through the regulation of p38/JNK signaling pathway
... HL60 cells and U937 cells were treated with PCA (1, 2, and 5 μ M). In HL60 cells, the expressions of p-P38 and p-JNK proteins were decreased significantly compared to that of the control group (Figure 4). Proteins ...
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BMP7 promotes proliferation of nephron progenitor cells via a JNK dependent mechanism
... BMP signaling pathway between cap mesenchyme and renal vesicle, the first morphologically distinct stage of nephron ...from JNK- mediated signaling to SMAD-mediated signaling in the transition ...
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β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
... of JNK signaling leading to radiosensitization ...of JNK in response to radiation [26-29], which is consistent with our ...mediate JNK activation, the association of β1 with the cytoskeletal ...
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Original Article Effect of halofuginone on the inhibition of proliferation and invasion of hepatocellular carcinoma HepG2 cell line
... of JNK and MEK/ERK signaling pathways [19]. In liver cancer, JNK plays dual roles: on one hand, it facilitates inflammation in hepatic microenvironment to support tumor progres- sion, on the other ...
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Anopheles aquasalis transcriptome reveals autophagic responses to Plasmodium vivax midgut invasion
... Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection.. Choy A, Severo MS, Sun[r] ...
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Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells
... growth was mediated through inhibiting TrxR1 activity. By inhibiting TrxR1 activity, WZ35 combined with cis- platin markedly induced the production of ROS, acti- vated p38 and JNK signaling pathways, and ...
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LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
... Our results showed that RAP increased the expression of IL-1β and TNF-α in a dose-dependent manner (Fig. 3a, b). In addition, modest but significant change in Lrp1 mRNA was observed in cells treated for 4 h with high ...
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Autocrine parathyroid hormone like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK ATF2 cyclinD1 signaling
... In summary, we report that ICC-secreted PTHLH acts in an autocrine manner in intrahepatic cholan- giocarcinoma progression by activating the canonical ERK/JNK signaling pathway. However, our findings focus ...
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Hepatitis C Virus Activates Bcl-2 and MMP-2 Expression through Multiple Cellular Signaling Pathways
... NS4B is a poorly characterized hydrophobic protein that may play a role in the induction of cell transformation and tumorigenesis (14). Other activities associated with NS4B in- clude modulation of NS5A ...
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RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression
... The JNK pathway has been implicated in oncogenic transformation and cell proliferation during the pathogenesis of cancer in various tissues ...the JNK pathway in the promotion of colon carcinogenesis has ...
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Nuclear movement regulated by non Smad Nodal signaling via JNK is associated with Smad signaling during zebrafish endoderm specification
... Nodal signaling and nuclear envelope proteins. Third, the non-Smad JNK signaling pathway, which acts downstream of Nodal signaling, regulates nuclear movement independently of ...two ...
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