JNK signalling
Cell death induced regeneration in wing imaginal discs requires JNK signalling
... of JNK activity, is concentrated in a narrow strip of apical cells ...that JNK signalling is activated in the leading edges during wound ...the JNK pathway within the dying domain has no ...
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DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt’s lymphoma
... In this study, we show that the type IV DUSP, DUSP16, is subject to methylation-dependent transcriptional silencing in BL, resulting in the deregulation of JNK signalling. There are a large number of DUSP ...
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Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis
... This study represents the first in-depth exploration of Strip, Cka and TNF-JNK signalling during Drosophila spermatogenesis, and opens new avenues of investigation for these genes and pathways in other ...
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Distinct regenerative potential of trunk and appendages of Drosophila mediated by JNK signalling
... have made use of the UAS-hep CA transgene that induces high levels Fig. 5. JNK signalling is required to elicit a proliferative response after rpr ablation of the Sd domain. (A-D ′ ) Confocal sections of ...
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Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
... cytokine-mediated JNK signalling and related functional outcomes in human endothelial ...assess signalling parameters mediated by P2YRs, Interleukin-1β (IL-1β), TNFα and ...of JNK and ...
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JNK signalling mediates aspects of maternal immune activation : importance of maternal genotype in relation to schizophrenia risk
... of JNK on chemokine re- sponses of immune cells, to place these results in con- text, those available would have predicted a general reduction in CCL5 production due to haploinsufficiency for ...Map2k7. JNK ...
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Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
... (JNK) signalling pathway. When JNK signalling pathway is blocked by inhibitor SP600125, hepatic stellate cells (HSCs) activation is inhibited, with less proliferation and reduced expression of ...
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JNK signalling is necessary for a Wnt and stem cell dependent regeneration programme
... and jnk, as our phylogenetic analysis indicated this gene was closer to other animal Jun ...hem, jnk and junl-1 reveal a clear role for JNK signalling in promoting posterior regeneration, ...
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The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative feedback loop during epithelial morphogenesis
... comprehend JNK-regulated genital plate formation, we developed live imaging of the male pupal disc undergoing ...other JNK-dependent epithelial sheet movements like DC of the embryo, thorax closure of the ...
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Original Article Human-specific CHRFAM7A protects against radiotherapy-induced lacrimal gland injury by inhibiting the p38/JNK signalling pathway and oxidative stress
... Abstract: Radiotherapy-induced lacrimal gland injury often causes dry eye. Oxidative stress and local inflammation are the primary consequences of radiotherapy-induced injury. The most recent research shows that the ...
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<p>Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling</p>
... PANC-1 and PANC-1/Gem treated with oridonin or gemcita- bine were collected after 24-h incubation, rinsed twice with phosphate-buffered saline (PBS) and lysed in radioimmuno- precipitation assay lysis buffer (Beyotime ...
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ERK and JNK signalling regulate gene networks that stimulate metamorphosis and apoptosis in tail tissues of ascidian tadpoles
... We chose to focus on MAPK signalling cascades for two reasons. First, we and others have shown that the inhibition of ERK prevents tail regression and apoptosis during ascidian metamorphosis (Chambon et al., 2002; ...
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JNK signalling in cancer: in need of new, smarter therapeutic targets
... Persistent ultraviolet (UV) radiation exposure is the major cause for the development of skin cancer, which comprises histologically distinct skin neoplasms. These include squamous cell carcinoma (SCC), basal cell ...
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Apical deficiency triggers JNK dependent apoptosis in the embryonic epidermis of Drosophila
... on JNK- dependent apoptosis in the dorsal epidermis In the dorsal epidermis of crb mutants, JNK signalling is activated, yet this does not lead to rpr expression and ...prevent JNK ...
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Original Article Suppression of the CXCL4-JNK pathways contributes to the attenuation of DSS-induced acute colitis in mice
... facilitating JNK activation, respectively ...The JNK protein kinase, a member of the MAP kinase family, may contribute to multiple physi- ological processes, including the regulation of cell proliferation ...
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Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
... Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth ...
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JNK suppresses pulmonary fibroblast elastogenesis during alveolar development
... triplicate, JNK activity at PND14 was 11-fold higher than JNK activity at PN 8 weeks (Figure ...of JNK was increased in PND14 lung com- pared to PN 8 week without phosphorylation of the p46 ...total ...
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The expression of p ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin Beck disease
... human JNK, p38, ATF2 and GAPDH with the following cycling conditions: 94°C for 2 mins, 94°C for 10 s, 58°C for 30 s, and 72°C for 30 s for 40 cycles, followed by a melting curve ...of JNK, a 107-bp fragment ...
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An In Silico Comparative and Pathway Analysis of Targeted Genes of Diabetic Retinopathy: A Prognostic Approach towards Diabetic Retinopathy
... miRNA – target pathway interactions were performed for miRNA 21 and their targeted gene IL1B by using mirwalk database, their interaction was found in apoptosis and MAPK signalling pathway which are previously ...
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Reovirus Infection Activates JNK and the JNK-Dependent Transcription Factor c-Jun
... Although we were able to show strain-specific differences in the activation of ERK in infected cells, we have been unable to map this phenomenon to a specific reovirus gene segment (results not shown), suggesting that ...
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