K+ channels
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
... of K channels still re- maining at the juxtaparanodes ...other K channels present in these axons (Devaux et ...Na channels in the nodes of Ranvier, the function of the juxtaparanodal ...
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An inhibitor of K+ channels modulates human endometrial tumor-initiating cells
... ion channels are important contributors to the malignant phenotype in cancer cells and as such have been shown to drive progression of cancers of the breast, prostate, endometrium and brain ...which K + ...
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Upregulation of Kv1.3 K channels in microglia deactivated by TGF-
... DR K ⫹ currents in TGF-  -treated microglia closely resemble those in activated microglia (10) and in other macrophages (7, ...DR channels in TGF-  -treated ...Kv1.5 channels in TGF-  -treated ...
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Review: Evolutionary link between prokaryotic and eukaryotic K+ channels
... All other sequences retrieved from the database search with ecoKchA contain a core region built from two transmembrane segments and linked to a C-terminal PNBD (2TMS/PNBD). These genes are currently found in the genomes ...
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Activation of Ca2+ dependent K+ channels in human B lymphocytes by anti immunoglobulin
... Ca2+-dependent K+ channels, and activation of these channels by increasing intracellular calcium generally leads to a hyperpolarization of the plasma ...Ca2+-dependent K+ channels are ...
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High yield purification of full-length functional hERG K+ channels produced in Saccharomyces cerevisiae
... gated K + channels such as the significantly shorter (282 amino acids) KvAP channel from the archae Aeropyrum pernix [21] and the 499 amino acids ...Kv1.2 K + channel from rat ...
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Changes in Inward Rectifier K+ Channels in Hepatic Stellate Cells During Primary Culture
... rectifier K + channel genes and characterized the inward- rectifying K + currents in cultured rat ...inward-rectifying K + currents and their changes during the in vitro activation ...rectifier ...
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Pore properties of Lymnaea stagnalis neuron stretch activated K+ channels
... selective channels in rat supraoptic neurons appear to have mechanotransduction as their primary physiological function (Oliet and Bourque, 1993a,b), membrane tension in molluscan neurons is normally buffered by ...
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M‐type K⁺ channels in peripheral nociceptive pathways
... key K + channel genes (including Kcnq2 and Kcnq5) (Rose et ...of K + channels is expected to result in depolarized and more excit- able fibres, which is indeed one of the characteristic of neuro- ...
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X ray microanalysis of Rb+ entry into cricket Malpighian tubule cells via putative K+ channels
... The results for cellular element concentrations extracted from X-ray images (e.g. Fig. 2A–D) are summarised in Fig. 3. There were no significant differences (P>0.05) in Cl concentration between treatments. Cytoplasmic ...
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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M type K+ channels and activation of Ca2+ activated Cl– channels
... Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain- inducing substances. When released at sites of tissue damage or inflammation, or applied exogenously, BK produces acute spontaneous ...
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Regulation of Inwardly Rectifying K Channels in Retinal Pigment Epithelial Cells by Intracellular pH
... The RPE has an intimate anatomical and functional relationship with the adjacent photoreceptor cells. Microvilli project from the apical surface of the RPE and interdigitate with the photoreceptor outer segments, ...
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O2 deprivation inhibits Ca2+ activated K+ channels via cytosolic factors in mice neocortical neurons
... Receptor modulation has also been important in hypoxia- or ischemia-induced release of endogenous transmitters or neurohormones, which might couple to receptors and modulate the channel activity. One substance known to ...
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Characterization of voltage and Ca(2+) activated K+ channels in squid olfactory receptor neurons
... and K + currents, and respond to ink, L -Dopa and dopamine with a hyperpolarization that inhibits the firing of action potentials (Lucero et ...or K + channels. To help elucidate the role(s) that ...
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Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K+ channels activation
... In castor oil-induced diarrhoea and intestinal fluid accu- mulation models, Mc. Cr showed antidiarrhoeal and anti- secretory activities at 150 and 300 mg/kg, similar to the effects of cromakalim [38] and loperamide [39], ...
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Impairment of skeletal muscle adenosine triphosphate–sensitive K+ channels in patients with hypokalemic periodic paralysis
... (ATP)–sensitive K + (K ATP ) channel is the most abundant K + channel active in the skeletal muscle fibers of humans and ...muscular K ATP channel in a skeletal muscle disorder known as ...
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Differential Effects of Angiotensin II on Intra Renal Hemodynamics in Rats; Contribution of Prostanoids, NO and K+ Channels
... After surgery and placing of probes for recording regional blood flows, a 30- to 45-min equilibration period was allowed. AII was administered by an infusion pump (Model 100, SP 100i syringe pump, WPI, USA) at graded ...
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Initiation of human myoblast differentiation via dephosphorylation of Kir2 1 K+ channels at tyrosine 242
... In parallel experiments, we assessed Kir2.1 channel activity in the presence of 10 g/ml Brefeldin A, an inhibitor of endoplasmic reticulum (ER) to Golgi transport (Fig. 1C). This was done to evaluate whether the Kir2.1 ...
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HERG-like K Channels in Microglia
... HERG-like K 1 channels expressed in microglia in situ? There are numerous reports of IR channels in microglia in primary ...HERG-like K 1 cur- rents. Clearly, the pattern of K 1 channel ...
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Function of Specific K Channels in Sustained High-Frequency Firing of Fast-Spiking Neocortical Interneurons
... Neurons were visualized at 3 160 –200 magnification with near infrared light ( . 775 nm) transillumination, using a nuvicon tube camera (VE-1000, Dage, Michigan City, IN) and the DIC optics of a fixed-stage microscope ...
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