Keap1/Nrf2 signaling pathway
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
... the Keap1-Nrf2 pathway is an emerging target for PC prevention and ...Indeed, Nrf2 plays an either tumor-suppressive or promoting function in PC, which depends on the developmental stages of ...
15
Original Article MiR-7 involves the activation of Nrf2 pathway by targeting Keap1 in epileptic seizure
... Molecular signaling pathways that involves in epilepsy pathogenesis identify new therapeutic targets or biomarkers of intractable ...Moreover, Nrf2 and its two prominent transcriptional targets (HO-1 and ...
7
Original Article IL-17 enhances oxidative stress in hepatocytes through Nrf2/keap1 signal pathway activation
... diverse human liver diseases, including alco- holic liver disease, acute liver injury and chronic hepatitis B and C, primary biliary cirrhosis, hep- ato-cellular carcinoma and acute liver trans- plant rejection [12]. But ...
6
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
... and signaling aberra- tions, cancer cells generally have elevated levels of reactive oxygen species (ROS), which are balanced by an increased antioxidant capacity ...response. NRF2 induces tumori- genesis, ...
17
Original Article Study of the regulation and mechanism of SOX9 on podocytes in diabetic nephropathy by regulation of Nrf2-Keap1-ARE signaling pathway
... of Keap1 and decreased expression of Nrf2 and ARE in high glucose environment, while downregulation of SOX9 significantly inhi- bited Keap1 expression and promoted expres- sions of Nrf2 and ...
8
Acrolein exposure suppresses antigen-induced pulmonary inflammation
... the Nrf2 pathway through direct interaction with redox-sensing cysteine residues within its inhibitor Keap1 ...of Keap1, accumulation of Nrf2 protein, and in- duction of the ...
15
Original Article Phenethyl isothiocyanate potentiates anti-tumor effects of cisplatin through Nrf2/keap1 signaling pathways
... 35]. Nrf2, nuclear factor erythroid-2 related factor 2, is the key signaling protein within the ...genes. Keap1, Kelch ECH associating protein 1, is a very cysteine- rich protein [36] that regulates ...
10
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
... the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and detoxifying enzymes, thus playing a pivotal role in ...
17
Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... The Nrf2-Keap1-ARE signaling system is central to the induction of phase 2 genes by electrophiles and antioxi- dants ...vate Nrf2 and translocated into the nucleus, with increased expression ...
9
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
... stimulated Nrf2-knockdown RAECs (Figure ...an Nrf2-dependent mecha- ...activates Nrf2 signaling and the binding target of SchB. In general, Nrf2 exists in the cytoplasm by binding with ...
13
Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1
... NFκB-p65 pathway in ...B pathway or interferes with its transcriptional activ- ity [48, ...B signaling pathway, we might suppose that the transcrip- tion of genes controlled by these ...
13
<p>Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells</p>
... p62-KEAP1-NRF2 pathway in a time-dependent manner in bladder cancer ...p62, KEAP1 and NRF2 were detected by Western ...and NRF2 were evaluated by Western ...
10
<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>
... In this study, a rat model of AP was successfully estab- lished by injecting with sodium taurocholate into the pan- creatic duct and obvious lung injury was developed. The proin fl ammatory cytokines TNF- α , IL-1 β , and ...
12
Original Article The role of Keap1-Nrf2-ARE signal pathway in diabetic retinopathy oxidative stress and related mechanisms
... Healthy male SD rats (6 weeks old, body weight 220~240 g) were purchased from Weifang Medical Laboratory Animal Center. Trizol was purchased from Invitrogen (US). PrimeScript RT reagent kit and SYBR Green were purchased ...
7
Original Article Comparison of the effects of Shenfu injection and Shenmai injection on doxorubicin-induced chronic heart failure in rats
... conditions, Nrf2 is located in the cytoplasm and under oxi- dative stress. Nrf2 can be released from Keap1 and translocates into the nuclear, which con- trols the expression of phase2 antioxidant ...
11
Mechanistics of Prothymosin alpha and Nrf2 in the Keap1-Nrf2 mediated Oxidative Stress Response
... The backbone assignment of the human Neh2 domain was completed in order to identify amino acids that are involved in forming the binding interface with targets and to characterize the structural changes the protein ...
235
The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes
... on Nrf2 activation in mouse epidermis and human HaCaT ...of Nrf2 from the cytosol to the nucleus as an effect of stilbene treatment in both ...of Nrf2 translocation was the parent compound, ...
17
Journal of Applied Pharmaceutical Science
... the Nrf2-Keap1/ARE pathway, and Keap1 knockdown genetic approaches (Benson et ...2000). Nrf2 bind ARE and regulate expression and initiation of NQO1 ...While, Nrf2 knockout ...
5
Original Article Lycopene attenuates LPS-induced liver injury by inactivation of NF-κB/COX-2 signaling
... Lipopolysaccharide (LPS) was purchased from Sigma (St. Louis, USA). Elisa mice interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) kits were purchased from Hefei Bomei Biote- chnology CO., LTD (Hefei China). SOD and ...
9
<p>Identification of Pannexin 2 as a Novel Marker Correlating with Ferroptosis and Malignant Phenotypes of Prostate Cancer Cells</p>
... 6A). Nrf2 pathway plays a crucial role in oxidative stress, especially the Nrf2 ...reduce Nrf2 mRNA and protein expressions, and the downstream gene expressions (HO-1 and FTH1) (Figure 6B and ...
11