keloid fibroblasts
Original Article miR-183 inhibits connective tissue growth factor (CTGF) production in TGF-β1-treated keloid fibroblasts in vitro
... Abstract: CTGF plays a critical role in the development and progression of keloid (KL) fibrogenesis. However, the potential mechanisms of ECM deposition induced by overexpressing CTGF in keloid have not ...
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Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts
... As mentioned above, the etiology of keloid formation is complex and involves many participating factors. TGF-β1 is recognized as the main factor in promoting keloid formation to date. Furthermore, ECM ...
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Original Article Overexpression of sortilin promotes pro-nerve growth factor-induced apoptosis in keloid fibroblasts
... Abstract: Keloids are scars characterized by pathologically excessive dermal fibrosis and aberrant wound healing. Keloid fibroblasts (KFs) persistently proliferate and fail to undergo apoptosis, no ...
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Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts
... keloid fibroblasts in relation to cell signaling pathway and identifying other volatile compounds from different organic solvents should be carried ...treat keloid fibroblasts using ...
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Effects of Photodynamic Therapy Using Yellow LED-light with Concomitant Hypocrellin B on Apoptotic Signaling in Keloid Fibroblasts
... surgery. Keloid fibroblasts (KFB), the most critical cells in keloid tissue formation, proliferate abnormally and secrete excessive extracellular matrix in a fashion similar to benign tumors [1, ...
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Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts
... in keloid fibroblasts decreased significantly, corresponding to the down-regulation of ...of keloid fibroblast cultures by Sircol collagen assay 24 h and 48 h after transfection; results are shown as ...
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Asiatic Acid Isolated From Centella Asiatica Inhibits TGF-β1-induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation
... Interestingly, PPAR-γ also integrated with TGF-β/Smad signaling pathway in cancer biology. The activation of PPAR-γ could antagonize TGF-β1’s effect on cancer growth and metastasis[37]. Taken the apoptotic effect of AA ...
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The Comparison of the Levels of Leukotriene B4, TGF β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast
... recovery. Keloid occurs due to the increase in fibroblast production and collagen synthesis, thus it is included as fibroproliferative diseases ...[1]-[5]. Keloid incidents are estimated 15% - 20% among ...
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Inhibiting function of human fetal dermal mesenchymal stem cells on bioactivities of keloid fibroblasts
... In addition to some traditional therapies, there are many new therapeutic approaches, such as stem cell therapy, that have brought new hopes to managing ke- loid. Recent studies show that MSCs can regulate the ...
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AQUEOUS EXTRACT OF CENTELLA ASIATICA AS A POTENTIAL ANTI KELOID AGENT
... of keloid formation, via the TGF- ß1 expression in the inflammation stage of wound healing could positively be influenced by nitric oxide pathway 30 ...In keloid fibroblasts, the total fibronectin ...
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The effect of 5α oleandrin on keloid fibroblast activities
... in keloid tissues [11] and collagen production of keloid fibroblasts [12, ...the keloid pathological ...suppress keloid fibroblast proliferation better than mitomycin-C after 24 h of ...
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Angiotensin-II Mediates Nonmuscle Myosin II Activation and Expression and Contributes to Human Keloid Disease Progression
... Human fibroblasts were obtained from surgical specimens per a protocol ap- proved by the institutional review ...from keloid tissue. Four keloid- derived dermal fibroblast cultures, derived from the ...
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Original Article Keloid-associated lymphoid tissues in keloid lesions express vitamin D receptor
... dermal fibroblasts, and collagen syn- thesis in keloid fibroblasts ...diac fibroblasts isolated from spontaneously hypertensive rats demonstrates increased fib- roblast proliferation and ...
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KELOID A DERMATOLOGICAL DISORDER: A REVIEW
... keloidal fibroblasts have lower rates of apoptosis, and others have demonstrated a down- regulation of apoptosis-related ...keloidal fibroblasts have been found to have increased production of collagen and ...
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CASK mRNA in the keloid group was lower than that in normal control group (0.658±0.024
... in fibroblasts of human ...in fibroblasts of the keloid and normal skin were detected by Immunofluorescence ...in fibroblasts of keloid and normal skin were analyzed via reverse ...
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Vol 29, No 2 (2019)
... of keloid angiogenesis and its imbalance conducted a study aimed at examining the impact of periostin on angiogenesis in ...the keloid fibroblasts, thereby promoting ...in keloid development ...
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Resident fibroblasts in the kidney: a major driver of fibrosis and inflammation
... resident fibroblasts transdif- ferentiate into myofibroblasts and also into several dis- tinct phenotypic fibroblasts, which are involved in TLT formation ...p75NTR-positive fibroblasts in aged ...
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New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects
... The immune response and the immune system can be modulated by the interactions between essential fatty acids, eicosanoids, and free radicals coming from the diet. For the essential fatty acids, if there are enhanced ...
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Keloids and Hypertrophic Scars: A Review of Risk Factors, Pathophysiology, Prevention, Management, and Treatments in Dermatology and Surgical Practice
... may play a role in developing these pathological scars. These fibroproliferative lesions may be seen in patients with specific chromosomal changes and single nucleotide polymorphisms (SNPs). Clinically, dermatologists ...
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... This study presented several limitations. First, normal tissues as controls were not derived from the same subjects. Each donor may present different patterns of stemness characteristics due to the differences in age and ...
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