Kinase activity
Reversibility of defective adipocyte insulin receptor kinase activity in non insulin dependent diabetes mellitus Effect of weight loss
... receptor kinase activity was reduced by 50-80% and rose to approximately 65-90% (P less than ...receptor kinase defect that is present in NIDDM is largely reversible after weight ...receptor ...
10
Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus.
... To examine the relationship between the mitogenic function of p6Osrc and its levels of in vitro kinase activity, we measured the levels of p60src-associated kinase activity in PA101- and[r] ...
10
Isolation of mutants of bacteriophage T4 unable to induce thymidine kinase activity. II. Location of the structural gene for thymidine kinase.
... This contrasts to the finding that the total thymidine kinase activity in extracts prepared from cells infected with phage able to induce thymidine kinase is only twice as great as the a[r] ...
6
Probing of Protein Kinase Activity by Electrochemistry
... penetrate the SAM, thus producing a good electrochemical signal. Li et al. have demonstrated that the kinetics of phosphorylation and dephosphorylation mediated by kinases and phosphatases on electrode surface could be ...
13
Defining the physiological role of phosphatidylinositol 3-kinase protein kinase activity
... between Ras and p i 10 and that post-translational modification o f Ras was necessary for its stimulatory effect, although not for binding. Moreover, it was shown that Ras binding further increased the lipid ...
268
H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication
... ATM kinase activity during EBV in- fection; one report [42] concludes that ATM is important for efficient EBV lytic replication in Akata BX1 latent cells but another report [43] indicates that ATM is ...
11
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity
... Relative kinase activity of SjGlcNK (dark blue) and MvMak (cyan) toward different potential phosphate acceptors (xylose, sucrose, mannose, galactose, maltose, glucose, and ...and activity was ...
15
Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors
... other kinase sensors based on phosphorylatable NLS or nuclear exclusion sequences have been described in the literature both in yeast and in higher eukaryotes by using small domains of proteins known to relocalize ...
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Protein Kinase Activity in Equine Herpesvirus
... Characteristics of product: chemical studiesa 82p Treatment incorporated,b pmoles per mg of EAV protein remaining acid insoluble A BC 111 D E l I z 0 Although this experiment was a batch[r] ...
7
Perturbation of the p53 response by human papillomavirus type 16 E7.
... which plays an important role in mediating cell cycle progres- sion. We therefore examined cyclin-dependent kinase activity in control and E7-expressing cells. Steady-state levels of cyclin E protein were ...
9
Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response
... Aurora B specifically, was originally identified in Drosophila where a mutated form led to monopolar spindles which in turn led to its naming after the Aurora Borelalis [94]. Au- rora B acts in mitosis as the catalytic ...
94
Sequence and Structural Diversity of the S Locus Genes From Different Lines With the Same Self-Recognition Specificities in Brassica oleracea
... their kinase is identical in nucleotide sequence to the PCR product domain, which are important for kinase activity (Figure amplified with PS3 and PS21 (data not shown) and was ...
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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
... Several recent reports have shown that Flk-1/KDR recep- tors, when activated, will associate with PLC g, GTPase-acti- vating protein, Nck, and PI 3-kinase (12, 13). These interac- tions are probably mediated ...
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The dual kinase complex FAK-Src as a promising therapeutic target in cancer
... with kinase activity that is flanked by a N-terminal region that contains the FERM domain and by a C-terminal region that contains the FAT ...catalytic kinase activity and allows the binding ...
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Biochemical properties of p60v-src mutants that induce different cell transformation parameters.
... Analysis of chimeric src proteins derived from the mutant proteins revealed that lesions in the kinase domain inhibit in vitro kinase activity and confer temperature sensitivity on tyros[r] ...
9
Differential Requirement for Cell Fusion and Virion Formation in the Pathogenesis of Varicella-Zoster Virus Infection in Skin and T Cells
... serine/threonine kinase related to herpes simplex virus UL13 (33, ...expressing kinase-defective ORF47 protein re- tained some capacity to infect skin ...conserved kinase motif), while virus was ...
13
Böhm, Stefanie (2011): The Cdc48 Shp1 complex mediates cell cycle progression by positive regulation of Glc7. Dissertation, LMU München: Fakultät für Biologie
... Glc7 activity in shp1 results in Ipl1 hyperactivity at the kinetochore and causes SAC activation due to lack of ...Ipl1 kinase activity towards these substrates and thereby enables microtubule ...
120
Purification and properties of human hexokinase.
... low hexokinase activity, a single band stained for hexo- kinase activity was observed corresponding to the single. band stained for protein[r] ...
263
Reduced Activity of Mutant Calcium Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
... the kinase domain of PfCDPK1 to PfCDPK5 were aligned with Toxo- plasma gondii CDPK1 (TgCDPK1) as a ...the kinase activity of ...vitro kinase assay was set up as described in Materials and ...
12
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
... Cardiac-specific overexpression of Mst1 (K59R) works as dominant-negative Mst1 and significantly reduces apoptosis in response to I/R. To examine if activation of endoge- nous Mst1 is required for apoptosis in response ...
13