Kindlin-1
Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells
... that Kindlin-1 played a similar role as SARA to recruit Smad3 to TβRI for ...between Kindlin-1 and SARA, we did a co- IP assay with an anti-Flag antibody using lysates from HCT116 ...
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Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
... and kindlin-1 (or their mutants) were cloned into pGADT7 and pGBKT7 vectors, respectively, for ex- pressing the fusion proteins of AD-sharpin and BD- ...and kindlin-1. In this experiment, Bop1 ...
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Evaluation of Kindlin-1 and Ki-67 immunohistochemical expression in primary cutaneous malignant melanoma: a clinical series
... The most studied function of kindlins is their role in integrin activation. The term integrin was coined more than three decades ago to designate a family of cell- surface adhesion receptors, and the interrelationship ...
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Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats
... [15]. Kindlin-1 is an integrin binding protein which plays a key role in regulating integrin activity ...that Kindlin-1 controls cell pro- liferation through regulation of the Wnt/β-catenin ...
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Expression of an activated integrin promotes long distance sensory axon regeneration in the spinal cord
... Axons will not grow unless they have on their surface a receptor that recognizes a ligand in their environment. Our previous work has identified ␣ 9 integrin as such a receptor, recognizing tenascin-C, which is present ...
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Ussar, Siegfried (2008): Genetic analyses of Kindlins in mice. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... from Kindlin-1 -/- mice and Kindlin-1-depleted HT-29 cells showed that the cell detachment is caused by impaired activation of integrins leading to weak adhesion of IECs to the underlying ...
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Schmidt, Sarah Marianne (2011): The role of Kindlin-3 in cells of the haematopoietic system. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... of kindlin-1 causes photosensitivity and poikiloderma still needs to be ...vivo kindlin-1 shows a polar distribution within basal epidermal keratinocytes and is localized along the ...
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Prognostic implications of Kindlin proteins in human osteosarcoma
... the Kindlin protein ...analysis, Kindlin-1, Kindlin-2 and Kindlin-3 proteins were, respectively, localized in cytoplasm, nucleus, and cytoplasm of tumor cells, and all were aberrantly ...
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Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation
... example, Kindlin-1 is predominantly expressed in the epidermis and only weakly expressed in the ...Similarly, Kindlin-3 expression is restricted to hematopoietic cells, where it is the dominant form ...
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Wang, Hao-Ven (2008): Characterization of β1 Integrin Cytoplasmic Domain Binding Proteins. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... endogenous Kindlin-2 for FA recruitment in these cells. Kindlin-1 and Kindlin-3 expression could not be detected in these cells by RT-PCR (data not ...of Kindlin-3 localization within ...
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Distinct expression profiles and functions of Kindlins in breast cancer
... of Kindlin-1 were more frequently of an advanced grade (grade III) and they showed more often hormone recep- tors (ER and PR) negativity ( p = ...respectively). Kindlin-1 expression also ...
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Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism
... between Kindlin-2 and oncogenic tyrosine kinases have been ...and Kindlin-2 has been shown to enhance cancer cell spreading and migration ...the Kindlin- 2-integrin β1-AKT axis in ESCC cells, a ...
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1′ (1 Hydroxyethyl) N,N diphenylferrocene 1 carboxamide1 1
... The increasing importance of transition metal-catalysed enantioselective reactions has paralleled the development of new ligands (Togni, 1996; Perea et al., 1998). A variety of synthetic methods have been reported in the ...
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1 Carboxymethyl 3 iodo 1 pyridinium–iodide–(3 iodo 1 pyridinio)acetate (1/1/1)
... system may be regarded as normal; a search of the Cambridge Structural Database (Version 5.26; Allen, 2002) revealed 97 hits for the pyridinioacetate system (including any ring substituents and all varieties of the ...
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1 Benzylimidazolium hexafluorophosphate–1 benzylimidazole (1/1)
... structure, there are head-to-tail – stacking interactions between imidazole rings; the interplanar separation is 3.295 (1) A ˚ and the centroid–centroid separation is 3.448 (3) A ˚ . In the centrosymmetric anion, ...
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On the Behavior of Solutions of the System of Rational Difference Equations xn+1=xn 1/ynxn 1 1, yn+1=yn 1/xnyn 1 1, zn+1=xn/ynzn 1
... Recently, there has been great interest in studying diffe- rence equation systems. One of the reasons for this is a necessity for some techniques which can be used in investigating equations arising in mathematical ...
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1 Acetamido 1 (1 naphthyl)ethylene
... Enamides were extensively studied for practical use as the prochiral materials for the asymmetric synthesis of chiral amines, which can be used as resolving reagents, chiral auxiliaries and intermediates for the ...
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Pyrimidin 2 amine–1 phenylcyclopentane 1 carboxylic acid (1/1)
... H N hydrogen bonds. Self-assembly of these dimeric units results in a four-component supramolecular unit featuring a homosynthon between two molecules of the pyrimidin-2- amine involving two N—H O hydrogen bonds, and two ...
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The adsorption structure of furan on Pd(1 1 1)
... for the two models is similar, consistent with the R-factor values. While all four structures correspond to molecular locations in which the -C emitter atoms are in off- atop sites with almost identical heights and ...
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