Kindlin-2
Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... Additionally, Kindlin-2 can stabilize EGFR in breast cancer ...that Kindlin-2 could regulate EGFR signaling in ...targeting Kindlin-2 was transfected into M059K ...of ...
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IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis
... Since kindlin-2 recruits Arp2/3 to promote membrane protrusions during initial cell spreading [49, 50], it is rational to speculate that IKKε-mediated kindlin-2 S159 phosphorylation might ...
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Prognostic value of Kindlin-2 expression in patients with solid tumors: a meta-analysis
... protein, Kindlin-2 has binding sites for various interaction partners, such as integrin, actin, the filamin-binding protein migfilin, integrin-linked kinase (ILK) [11, ...that Kindlin-2 could ...
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Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation
... the Kindlin-2 promoter and showed a role for the transcription factor SP1 in Kindlin-2 transcriptional ...the Kindlin-2 promoter region revealed that most of the promoter ...
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Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2
... Kindlin-2 loss impairs multiple key signaling pathways in adipocytes. Consistent with the reduced mRNA expression, the levels of adipogenesis-related proteins, including Cebpα, Pparγ, and Ap2, were all ...
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Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism
... identified Kindlin-2, a significant prognostic marker in ESCC [39], as a target and mediator of the function of miR-200b in ESCC ...targeting Kindlin-2 ...
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Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling
... between Kindlin-2 knockdown and control cells, however, Kindlin-2 knockout induced an increase in E-cadherin expression, while Kindlin-2 overexpression caused a decrease in ...
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Ussar, Siegfried (2008): Genetic analyses of Kindlins in mice. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the Kindlin family that was functionally characterised was ...that Kindlin-2 localises to FAs, where it binds a LIM domain- containing adaptor protein, called Migfilin [173] (see figure ...the ...
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Kammerer, Patricia (2017): In-vitro reconstitution and structural analysis of integrin-proximal adhesome complexes. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... to kindlin-NT-647, it should vanish after denaturing of the ...fluorescent kindlin-2. This might be due to unspecific interactions of kindlin-NT-647 with pipet tips or plastic tubes in which ...
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The Integrin Equilibrium: Balancing Protein-Protein and Protein-Lipid interactions
... (kindlin-1, kindlin-2, kindlin-3) are evolutionarily the closest to the talin ...talin-1, kindlin-3 binds to the β 3 integrin cytoplasmic domain and is necessary for platelet integrin ...
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Distinct expression profiles and functions of Kindlins in breast cancer
... that Kindlin-2 involvement in cell invasion was less determinant than that of ...of Kindlin-2 in this type of ...of Kindlin-2 in MCF7 cells was shown to drive tumor formation in ...
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Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
... with kindlin-1 ...with kindlin-1 but not kindlin-2 or ...and kindlin [17], kindlin-1, as an integrin binding partner, may re- cruit sharpin but not the talin head to integrin ...
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Prognostic implications of Kindlin proteins in human osteosarcoma
... used: Kindlin-1 (rabbit polyclonal antibody; Millipore, Billerica, CA, USA; 1:100 dilution), Kindlin-2 (rabbit polyclonal antibody, Millipore; 1:150 dilution), Kindlin-3 (rabbit polyclonal ...
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Wang, Hao-Ven (2008): Characterization of β1 Integrin Cytoplasmic Domain Binding Proteins. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... for Kindlin-3, which is exclusively expressed in cells of hematopoietic ...for Kindlin-1 expression in epithelial cells of the skin and the gastrointestinal tract and Kindlin-2 in striated and ...
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The Biophysics Of Leukocyte Adhesion Deficiency
... T cells must adhere in the vasculature to traffic into the lymphatics to perform immune surveillance and maintain homeostasis (1). In addition, T cells are often called upon to exit the bloodstream to enter the ...
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2′ (2 Fluorobenzylidene) 2 hydroxybenzohydrazide
... 1999). 2-Fluorobenzaldehyde is an effective intermediate in producing fever-allaying, pain- relieving and tumor-preventing medicines (Donnell & Bennett, ...
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2′ (2 Thienylmethylidene) 2 hydroxybenzohydrazide
... aldehyde (0.02 mol, 1.88 g) was added and the mixture re¯uxed for 2 h. The precipitate was collected by ®ltration and washed with ethanol. The product was recrystallized from ethanol and dried under reduced ...
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Dichotomization: 2 × 2 (×2 × 2 × 2...) categories: infinite possibilities
... Theory driven cutoffs may be chosen based on 1) a known dose-response relationship (i.e., the threshold where biological effects are known or postulated to start); 2) a literature review of cutoffs used in ...
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Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats
... Total protein was extracted from tissues using SDS lysis buffer (P0013G; Beyotime, China) for evaluating the pro- tein expressions of Kindlin-1, Wnt 10a, and β-catenin. The concentration of extracted protein ...
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(Z) 2 (2 Methoxybenzylidene) 1 azabicyclo[2 2 2]octan 3 one
... A mixture of 2-methoxybenzaldehyde (0.408 g, 3 mmol) and 1-aza- bicyclo[2.2.2]octane hydrochloride (0.483 g, 3 mmol) was dissolved in 10% methanolic KOH (10 ml) and the solution refluxed for 5 h. The cooled ...
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