kinetochore-microtubule
Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs
... proper kinetochore-microtubule attachment is a prerequisite for faithful chromosome segregation during ...defective kinetochore- microtubule attachments and chromosome misalignment, and ...
11
The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond
... that microtubule-kinetochore attachments that do not generate tension are intrinsically unstable [46,50], presumably due to the activity of Aurora ...unstable kinetochore-microtubule ...
9
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments
... in kinetochore-microtubule attachment by phosphorylating the kinetochore proteins that directly interact with spindle microtubules, including the Ndc80 complex [3], the Dam1 complex [4], and the ...
16
Mps1 regulates kinetochore microtubule attachment stability via the ska complex to ensure error free chromosome segregation
... block microtubule attachment (nocodazole) or permit attachment but not tension across kinetochores ...Graded microtubule-sensitive phosphorylation is a hallmark of dynamic error correction and SAC signaling ...
37
A Redundant Function for the N-Terminal Tail of Ndc80 in Kinetochore–Microtubule Interaction in Saccharomyces cerevisiae
... segregation in the strains using the established “a-like faker” assay that measures the loss of chromosome III in haploid MATa cells (Strathern et al. 1981; Warren et al. 2004). The ndc80-112 and dam1-1 cells lose ...
9
Timing of anaphase promoting complex activation in mouse oocytes is predicted by microtubule kinetochore attachment but not by bivalent alignment or tension
... Homologous chromosome segregation errors during meiosis I are common and generate aneuploid embryos. Here, we provide a reason for this susceptibility to mis-segregation by live cell imaging of mouse oocytes. Our results ...
9
Ordered Kinetochore Assembly in the Human Pathogenic Basidiomycetous Yeast Cryptococcus neoformans
... proper kinetochore-microtubule interaction is crucial for high-fidelity chromosome ...of kinetochore assembly exist between unicellular yeasts and multi- cellular ...proper kinetochore in a ...
8
The Essentiality of the Fungus-Specific Dam1 Complex Is Correlated with a One-Kinetochore-One-Microtubule Interaction Present throughout the Cell Cycle, Independent of the Nature of a Centromere
... 2. Kinetochore localization of Dad2 does not depend on integrity of kinetochore-microtubule interaction in ...of kinetochore-microtubule ...
11
The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1
... defective kinetochore-MT attachments ...defective kinetochore- microtubule attachments in these cells, which explains the increase in chromosome congression failure ...the kinetochore, which ...
15
12_lecture_cell_cycle.ppt
... Intact nuclear envelope Chromosomes Microtubules Intact nuclear envelope Kinetochore microtubule Kinetochore microtubule Fragments of nuclear envelope Bacterial chromosome. (c) Diatoms a[r] ...
97
Böhm, Stefanie (2011): The Cdc48 Shp1 complex mediates cell cycle progression by positive regulation of Glc7. Dissertation, LMU München: Fakultät für Biologie
... other kinetochore proteins such as Ndc10 or Ndc80 could also be critical Ipl1 substrates that must be dephosphorylated by Glc7 to enable microtubule binding to kinetochores (Biggins et ...intact ...
120
Chromosome congression explained by nanoscale electrostatics
... from kinetochore microtubule disassembly (at kinetochores and poles) depends on the total number of kinetochore ...chromatid’s kinetochore attached to the opposite ...poleward-directed ...
7
Effect of the Pairing Gene Ph1 on Centromere Misdivision in Common Wheat
... The idea of multiple microtubule-binding sites on by the spindle in opposite directions (Figure 3, C and each sister kinetochore is supported by observations (we D). In common wheat, the[r] ...
10
Lesions in Many Different Spindle Components Activate the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiae
... point: Microtubule motors move along the surface of microtubules, and genetic and cell biological experi- ments have implicated motors in many aspects of mitosis and meiosis in a wide variety of ...of ...
10
Regulation of cell migration by dynamic microtubules
... of microtubule dynamics regulates multiple molecular factors The set of factors that transduce microtubule signals to the cell migration machinery can be roughly divided into three subsets: those delivered ...
18
Human kinetochores are swivel joints that mediate microtubule attachments
... the kinetochore and we now understand that the core structure assembles in a hierarchical fashion with the CCAN (constitu- tive centromere associated network) physically bridging CENP-A containing chromatin and ...
16
Super resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching
... Although we have detected clear signatures in the switching choreographies (Figure 4), these reflect regulatory and mechanical processes of a highly stochastic system. This stochasticity is evi- dent on many scales. ...
17
Reconstruction of the kinetochore: a prelude to meiosis
... Regulation of centromeres in other organisms Several pieces of evidence for centromere-telomere reposi- tioning and regulation of centromere proteins in the tran- sition from mitosis to meiosis have been reported in ...
8
Knockdown of PLC-gamma-2 and calmodulin 1 genes sensitizes human cervical adenocarcinoma cells to doxorubicin and paclitaxel
... Since CAMKs regulate microtubule dynamics by phosphorylation of the microtubule regula- tor stathmin [32], the overall effect of gene knockdown might cause disruption of microtubule dyna[r] ...
8
Kuznetsova, Anastasia (2013): Transient tetraploidy as a route to chromosomal instability. Dissertation, LMU München: Fakultät für Biologie
... inner kinetochore, associated with centromeric DNA, and more dynamic outer kinetochore, which is formed around the time of the nuclear envelope breakdown (reviewed in Maiato et ...the kinetochore is ...
142