Klotho protein
Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis
... Background: We aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance ...
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Original Article Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in mice
... 2008262. Klotho protein: 100 mg, Cloud- Clone Corp, American. Klotho protein kits (Ba- tch: 1606031), Determination of total superox- ide dismutase (SOD) kit method (WST-1) (aBatch 20160612), ...
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Correlation of serum levels of fibroblast growth factor 23 and Klotho protein levels with bone mineral density in maintenance hemodialysis patients
... serum Klotho protein levels. When the patient’s age and serum Klotho protein level of the osteopenia group with normal bone mass in the femo- ral neck were compared, there was no significant ...
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Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
... soluble Klotho among the various degrees of CKD patients, our results should be interpreted within the context of their ...soluble Klotho in the current study may be modified by the anti-hypertensive agents ...
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<em>Klotho</em>, stem cells, and aging
... of klotho transcript arises from the klotho gene. Secreted klotho arises from an alternative RNA ...membrane klotho protein encoded by the membrane form of klotho transcript is a ...
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Klotho in chronic kidney disease in Indian population
... alpha-Klotho protein in the ...of Klotho gene using Real Time PCR (RT PCR; Step One Plus Applied Biosystems) with Taqman genotyping assays (Assay numbers: For rs9536314-C_2983037_20; for rs1207568 - ...
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Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
... the Klotho gene, increases Klotho expression, and mitigated aortic calcification induced by IS in5/6-nephrectomized ...that Klotho methylation levels of IS-injected rats were significantly ...of ...
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Are S-Klotho’s Maximal concentrations dependent on Exercise Intensity and Time in young adult males?
... Although the association between s-Klotho and aerobic exercise training is not clear, s-Klotho reduces programmed cell death (apoptosis) through Nitric Oxide production and thus, supp resses ROS [17]. ...
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Urine klotho is a potential early biomarker for acute kidney injury and associated with poor renal outcome after cardiac surgery
... Histologically, proximal tubular epithelial cells lose their brush border membrane as well as the Klotho pro- tein expressed in the apical brush border, which may re- sult in an acute increase of uKlotho at early ...
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The parathyroid is a target organ for FGF23 in rats
... for Klotho and α-tubulin as loading ...membrane Klotho mRNA corrected for HPRT1 mRNA from microdissected parathyroid, thyroid, kidney, duode- num, liver, and ...kidney. Klotho mRNA expression is ...
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Influence of exogenous growth hormone administration on circulating concentrations of α-klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study
... The excessively high cardiovascular (CV) risk in patients with chronic kidney disease (CKD) is only partially explained by the higher prevalence of traditional risk factors [1]. There- fore, other CKD-related factors are ...
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The role of klotho in chronic kidney disease
... increase klotho expression (Table 1) [14]; these includethe following: (1) ...the klotho gene promoter reduces its activity by 30% to 40%, whereas DNA demethylation increases klotho ex- pression ...
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Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
... of klotho To further validate the role of klotho gene, we constructed a vector overexpressing klotho gene and delivered it into GC-7901 ...of klotho gene expression vector can establish 70–80% ...
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The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
... the Klotho variant with the meta- bolic syndrome could be linked to its observed influence on high blood glucose, high blood pressure, insulin re- sistance, hypertriglyceridemia and endothelial function [17, ...in ...
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FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model
... soluble Klotho proteins. Soluble Klotho protein in serum was immunoprecip- itated and detected by Western blotting as described with modifications ...μL protein-G Agarose (Thermo Fisher ...
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Klotho sensitive regulation of dendritic cell functions by vitamin E
... of klotho in DCs and whether klotho may contribute to the altered phe- notypes of VitE-treated mature ...of klotho and the effects of VitE on the expression of co- stimulatory molecule CD86 in, the ...
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Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients
... for klotho gene promoter polymorphism ...serum klotho was correlated with verbal fluency after adjusted for age, but not memory or executive ...serum klotho is not an independent risk factor of ...
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Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis
... Whether Klotho and FGF-23 act independently of each other on the cardiovascular system in CKD patients is not ...of Klotho, ...hand Klotho has recently been shown to be associated with PWV, in a ...
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Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees
... Background: Throughout life, physiological homeostasis is challenged and the capacity to cope with such challenges declines with increasing age. In many species, sex differences exist in life expectancy. Sex-specific ...
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Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy
... LC3-II/LC3-I protein levels peaked 1 day after CLP and then gradually decreased (Figure 1B), whereas P62 protein levels changed in the opposite ...P62 protein levels were the lowest 1 day after CLP ...
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