L-lactide-co-glycolide)
Fabrication of electrospun poly(d,l lactide-co-glycolide)80/20 scaffolds loaded with diclofenac sodium for tissue engineering
... Background: Adaptation of nanotechnology into materials science has also advanced tissue engineering research. Tissues are basically composed of nanoscale structures hence making nanofibrous materials closely resemble ...
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Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs
... acid) (PLGA) nanoparticles. The aim of this study was to develop a local delivery device, PLGA-lovastatin-chitosan-tetracycline nanoparticles, which allows the sequential release of tetracycline and lovastatin to ...
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Antitumoral activity of L-ascorbic acid-poly-D,L-(lactide-co-glycolide) nanoparticles containing violacein
... Abstract: It has been demonstrated that tumoral cells have a higher uptake of ascorbic acid compared to normal cells. This differential characteristic can be used as a way to improve the specificity of antitumoral ...
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Synthesis and Characterization of Poly(D,L Lactide co Glycolide) Copolymer
... The copolymer poly(D,L-lactide-co-glycolide) is one of the most interesting polymers for medical applications. This interest is justified by the fact that it is bioreabsorbable, biocompatible ...
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Physicochemical features and transfection properties of chitosan/poloxamer <br />188/poly(D,L-lactide-co-glycolide) nanoplexes
... Abstract: The aim of this study was the evaluation of the effects of two emulsifiers on the physicochemical and technological properties of low molecular weight chitosan/poly ...
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Interaction of Immune System Protein with PEGylated and Un PEGylated Polymeric Nanoparticles
... (D, L-lactide-co-glycolide) (PLGA), polylactic acid (PLA), gelatin and poly-alkyl-cyano-acrylates (PACA) are attracting a great deal of research interest due to their potential to deliver ...
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Electric Conductivity of Electrolytic Copper Powder Filled Poly(Lactide-co-Glycolide) Composites
... 0.4 vol. % – 7.2 vol. % of copper powder filled PLGA polymer composites were prepared. Also, the reference samples consisting of pure PLGA and pressed copper powder were prepared. ...
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Novel docetaxel loaded nanoparticles based on poly(lactide co caprolactone) and poly(lactide co glycolide co caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies
... Poly(L-lactide- co-caprolactone-co-glycolide) (PLGA-PCL) (L-lactide: glycolide:caprolactone 70:10:20 molar ratio, inherent viscosity ...
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Poly(d,l-lactide-<em>co</em>-glycolide)–chitosan composite particles for the treatment of lung cancer
... Abstract: Tumor heterogeneity makes combination chemotherapy one of the preferred modes of treatment regimens. In this work, sequential exposure of two anticancer agents, paclitaxel (Tx) followed by topotecan (TPT), was ...
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<em>Chlamydia trachomatis</em> recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine
... D, L-lactide-co-glycolide; PBS, phosphate-buffered saline; rMOMP, recombinant major outer membrane protein; GM-CSF, granulocyte- macrophage colony-stimulating factor; IL, interleukin; G-CSF, ...
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Synthesis of Amorphous Polylactide and Poly(lactide-co-glycolide) Containing High L-form Enantiomer for Use in Controlled Release Drug Delivery
... of L-lactide (LL) copolymerization on the properties of poly(D,L-lactide) (PDLL) and poly(D,L-lactide-co-glycolide) (PDLLG) copolymers and its drug release ...
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OCULAR DRUG DELIVERY: A REVIEW
... (D, L- lactide-co- glycolide) (PLGA) polymers are biocompatible and biodegradable nature, the most studied polymer for the ocular drug ...and lactide: glycolide ...
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FORMULATION AND EVALUATION OF BSA LOADED PLGA MICROPARTICLES
... (D, L-lactide-co-glycolide) (PLGA) microspheres containing bovine serum albumin (BSA) as a model drug and to evaluate the various physicochemical characteristics of the formulations, namely ...
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Fabrication of Biodegradable Polymeric Microspheres with Controllable Porous Structure for Cell Delivery
... Poly(D,L-lactide-co-glycolide) (PLGA, 75:25, Mw~106000) was purchased from Birmingham Polymers (Pelham, AL, USA). Gelatin (type A, from porcine skin), PVA (Mw13 000–23 000, 98% hydrolyzed), ...
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Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma
... Abstract: Despite aggressive treatment with radiation and combination chemotherapy following tumor resection, the 5-year survival rate for patients with head and neck cancer is at best only 50%. In this study, we ...
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Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-<em>co</em>-glycolide) nanoparticles for controlled release and light protection of resveratrol
... Background: Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of ...
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Benefits of biphasic calcium phosphate hybrid scaffold-driven osteogenic differentiation of mesenchymal stem cells through upregulated leptin receptor expression
... A composite system was developed using poly(lactide-co- glycolide) (PLGA) copolymer, coralline HA, BCP ceramics, and collagen as a carrier matrix for MSCs. PLGA (300 mg; Boehringer Ingelheim, ...
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Induction of long lasting protective immunity against Toxoplasma gondii in BALB/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide co glycolide) microparticles
... We then determined whether PLG-rSAG1 microparti- cles could confer effective protection in mice. Eight weeks after boosting (the 10th week), all groups of 10 mice each were subcutaneously challenged with 1 × 10 4 live ...
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Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake
... µ L of LDH was used to validate the ...µ L of the medium was transferred to a fresh 96-well ...µ L of LDH reaction mixture for 15 minutes at room temperature and the absorbance was measured at 450 nm ...
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Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
... Here, we reported a robust aptamer–polydopamine-functionalized mannitol-functionalized poly(lactide-co-glycolide) (M-PLGA)– d - α -tocopheryl polyethylene glycol 1000 succinate (TPGS) [r] ...
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