-Lactamases (ESBL)
Antibiotic resistance pattern in Pseudomonas aeruginosa isolates with special reference to co-existence of different β-lactamases
... Treatment failure due to multidrug resistant gram-negative bacteria is a concerning threat to the clinicians worldwide. Among them, Pseudomonas aeruginosa, presents with a remarkable capacity of surviving in conditions ...
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Assessment of extended-spectrum β-lactamases and integrons among Enterobacteriaceae in device-associated infections: multicenter study in north of Iran
... are sulf-hydryl variable (SHV), cefotaxime-beta lactamases (CTX), Vietnam extended-spectrum β-lactamase (VEB) and Guyana Extended-Spectrum ß-lactamases (GES) genes. Integrons as mobile DNA elements, are ...
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Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology
... Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam ...
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Prevalence of CTX M β Lactamases in Philadelphia, Pennsylvania
... CTX-M  -lactamases were thought to be rare in the United States, but a recent study in Texas showed that up to 70% of extended-spectrum  -lactamase (ESBL)-containing members of the Enterobacteriaceae family were ...
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DETECTION CTX M TYPES EXTENDED SPECTRUM β LACTAMASES (ESBLs) IN ESCHERICHIA COLI ISOLATION FROM PREGNANT URINARY TRACT INFECTIONS (UTIs) IN BASRA, PROVINCE, IRAQ
... The ability to production ESBLs is contributors in the problem of resistance to antimicrobial. [6] Cefotaxim hydrolyzing (CTX-M) ESBL family has been increasing in frequency around the world. [8,9] ESBLs originate ...
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Phylogenetic typing and detection of extended-spectrum β-lactamases in Escherichia coli isolates from broiler chickens in Ahvaz, Iran
... This study was conducted to reveal the phylogenetic background, to detect the genes encoding TEM, SHV and CTX-M-15 extended-spectrum β-lactamases (ESBL), and to analyze their distribution in phylo-groups of 150 ...
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Molecular Characteristics of Extended Spectrum β Lactamases in Escherichia coli and Klebsiella pneumoniae and the Prevalence of qnr in Extended Spectrum β Lactamase Isolates in a Tertiary Care Hospital in Korea
... Purpose: Extended spectrum β -lactamases (ESBLs) are cephalosporinases that confer resistance to a wide variety of oxyimino cephalosporins and create serious therapeutic problems. In addition, the quinolone ...
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High levels multi-resistance to antibiotics among extended-spectrum β-lactamases-producing Enterobacteriaceae from Northwest Morocco
... Infections provoked by extended spectrum β-lactamases (ESBL) producing Enterobacteriaceae are increased worldwide and are often associated with amplified morbidity and mortality. Identification and antibiotic ...
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Detection of Ampc and Extended-Spectrum Beta-Lactamases in Clinical Isolates of Pseudomonas Aeruginosa from Patients with Cystic Fibrosis
... Chronic Pseudomonas aeruginosa lung infection is the main cause of morbidity and mortality in cystic fibrosis (CF) patients. About 80% of adults with CF suffer from the chronic P. aeruginosa infection (1,2). In the lung ...
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Using Nucleic Acid Microarrays To Perform Molecular Epidemiology and Detect Novel β Lactamases: a Snapshot of Extended Spectrum β Lactamases throughout the World
... Single- and multiple-amino-acid substitutions around the ac- tive site in the parental narrow-spectrum TEM- and SHV-type enzymes (i.e., TEM-1 and -2 and SHV-1 and -11) are the basis of ESBL-mediated resistance. To date, ...
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Prevalence and molecular characterization of β lactamases in clinical isolates of klebsiella pneumoniae from north of palestine
... Among the 51 tested strains of K. pneumoniae, the prevalence of ESBLs, MBLs and AmpC β-lactamases using multiplex PCR technique was 92.2%, 9.8 and 3.9%, respectively. The majority of isolates producing a single ...
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Detection of metallo β lactamases encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal
... Abstract Objectives: This study was carried out to determine the prevalence of metallo-β-lactamases MBLs producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to det[r] ...
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Occurrence and detection of AmpC β lactamases among clinical isolates of Enterobacteriaceae at a tertiary care hospital
... Among the beta-lactamases, the most common is production of ESBLs & AmpCs. Ambler class C and Bush group 1 beta-lactamase enzyme, AmpC Beta-Lactamases are being reported worldwide. These enzymes confer ...
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Molecular Epidemiology and Characterization of Plasmid Encoded β Lactamases Produced by Tunisian Clinical Isolates of Salmonella enterica Serotype Mbandaka Resistant to Broad Spectrum Cephalosporins
... We studied 31 clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins and recovered in Tunisia over a 5-year period. The transferability of this resistance was demonstrated ...
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Development of a Sensitive and Specific Enzyme Linked Immunosorbent Assay for Detecting and Quantifying CMY 2 and SHV β Lactamases
... -Lactamase protein expression and purification. The SHV-1 and CMY-2 -lactamases expressed in E. coli were liberated by periplasmic fractionation and purified according to previously described methods (19, 20; M. ...
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Detection of prevalence of metallo-beta lactamases in clinical isolates of imipenem resistant Pseudomonas aeruginosa from neonatal septicaemia cases in a tertiary hospital in Odisha, India
... Early and appropriate antimicrobial therapy is one key determinant in the ultimate outcome of the patient with sepsis. This may help in reducing mortality and morbidity. The rapid and irrepressible increase in ...
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Extended Spectrum Beta lactamases screening in Escherichia coli and Klebsiella isolates and confirmation by molecular method
... BETA LACTAMASES SCREENING IN ESCHERICHIA COLI AND KLEBSIELLA ISOLATES AND CONFIRMATION BY MOLECULAR METHOD" is a confide and genuine research work carried out by me in the department of Microbiology, Sree ...
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Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates
... Given the clear differences in spectrum of activities for Vaborbactam and biyclic boronates, with the latter in general appearing better in vitro, there appear to be scope for improving the activity of boronates by ...
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Bench to bedside review: The role of β lactamases in antibiotic resistant Gram negative infections
... Resistance in Gram-negative pathogens is increasing at an alarming rate. New β-lactamases that are transferred among species on plasmids with multiple resistance factors are also being described as a continuing ...
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Antibiotic susceptibility profile and extended spectrum β-lactamases production by uropathogenic Escherichia coli from tertiary care hospital of rural settings
... Antibiotic susceptibility profile and extended spectrum β-lactamases production by uropathogenic Escherichia coli from tertiary care hospital of rural settings.[r] ...
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