lactic acidosis
Effect of hydration status on cerebral blood flow and cerebrospinal fluid lactic acidosis in rabbits with experimental meningitis
... The effects of hydration status on cerebral blood flow (CBF) and development of cerebrospinal fluid (CSF) lactic acidosis were evaluated in rabbits with experimental pneumococcal meningitis. As loss of ...
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Lactic acidosis and severe septic shock in metformin users: a cohort study
... severe lactic acidosis, represented by blood lactate higher than 10 mmol/L at hospital ...of lactic acidosis in metformin users was different, as reflected by better ...
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Profound Neonatal Hypoglycemia and Lactic Acidosis Caused by Pyridoxine-Dependent Epilepsy
... in hematemesis, frequent episodes of mouthing movements, eye rolling, and generalized stiffening of the limbs at the time of presentation to the local pediatric emergency department at the age of 4 days. Her blood ...
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Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis
... Methods: We present the case of a term newborn with persistent hypoglycemia on postnatal day 1, who developed severe lactic acidosis, aggravating under intravenous glucose administration. Routine metabolic ...
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Recurrent Acute Life-threatening Events and Lactic Acidosis Caused by Chronic Carbon Monoxide Poisoning in an Infant
... the lactic acidosis resolved with only support- ive care and ...of lactic acidosis that were evaluated and considered very unlikely were adrenal insufficiency and congenital lactic aci- ...
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Recoverable, Record-High Lactic Acidosis in a Patient with Glycogen Storage Disease Type 1: A Mixed Type A and Type B Lactate Disorder
... disease, is one of the most severe forms of glycogen storage disease as lack of G6Pase deleteriously impacts on both gluconeogenesis and glycogenolysis. The inability to con- vert glucose-6-phosphate (G6P) to glucose ...
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Reversible Lactic Acidosis in a Newborn With Thiamine Transporter-2 Deficiency
... including lactic acidosis, high excretion of a -ketoglutarate, and increased levels of leucine and iso- leucine, could be due to the decreased activity of these thiamine-dependent mitochondrial enzymes (Fig ...
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ECG Changes in Acute Experimental Ruminal Lactic Acidosis in Sheep
... ruminal acidosis is one of the - most dramatic forms of ruminal microbial fermentative disorders and in some cases is lethal in less than 24 ...named lactic acidosis, toxic indigestion, grain ...
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Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis
... A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill ...regarding lactic acidosis treatment and recommended that ...
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Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication
... [21]. Lactic acidosis can develop in cases of drug accumulation but is usually attributed to other concomitant precipitating ...cause lactic acidosis even in the absence of other obvious ...
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Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt Like Lymphoma
... in lactic acidosis of hematological malignancies is ...with lactic acidosis ...tic acidosis, this is an interesting observation since IGF-1 induces the expression of hexokinase which ...
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Profound Neonatal Hypoglycemia and Lactic Acidosis Caused by Pyridoxine-Dependent Epilepsy
... and lactic acidosis in addition to intrac- table multifocal and myoclonic seiz- ures and neonatal encephalopathy mimicking hypoxic ischemic enceph- alopathy due to PDE caused by muta- tions in the ALDH7A1 ...
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Controlled Clinical Trial of Dichloroacetate for Treatment of Congenital Lactic Acidosis in Children
... It is possible that the initiation of DCA therapy earlier in the course of illness or its administration to discrete populations at a higher dose than we used would im- prove outcome in patients like those we studied. ...
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Evaluation of Long-term Treatment of Children With Congenital Lactic Acidosis With Dichloroacetate
... the safety and efficacy of dichloroacetate in this patient population is derived from open-label studies in 1 or a few individuals. Recently, a randomized, controlled trial evaluated oral dichloroacetate at a dose of ...
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Type B Lactic Acidosis Secondary to Thiamine Deficiency in a Child With Malignancy
... Clinicians typically associate lactic acidosis with tissue hypoperfusion (type A). This condition arises because with decreased oxygen supply to tissues, the electron transport chain cannot oxidize ...
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Treatment of Lactic Acidosis with Dichloroacetate in Dogs
... characterized by blood lactate levels >5 mM and arterial pH <7.25. In addition to supportive care, treatment usually consists of intravenous NaHCO 3 , with a resultant mortality >60%. Dichloroacetate (DCA) is a ...
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Metformin associated lactic acidosis complicates orthotopic liver transplantation
... associated lactic acidosis (MALA) is a rare condition and clinicians require a high index of suspicion MALA has not previously been reported during liver transplant and making a definitive diagnosis in the ...
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Succinate and the shortcut to the cure of metformin-induced lactic acidosis
... Metformin is a safe drug when correctly used in properly selected subjects [4]. None- theless, it rarely induces lactic acidosis, especially when renal failure leads to its acci- dental accumulation. ...
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THIAMINE-RESPONSIVE LACTIC ACIDOSIS IN A PATIENT WITH DEFICIENT LOW-KM PYRUVATE CARBOXYLASE ACTIVITY IN LIVER
... DEFICIENT LOW-KM PYRUVATE CARBOXYLASE ACTIVITY IN LIVER THIAMINE-RESPONSIVE LACTIC ACIDOSIS IN A PATIENT WITH. Services[r] ...
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Alkali Therapy in Lactic Acidosis
... severe acidosis resulted in systemic alkalinization without major changes in PaCO2 and intracellular pH in hepatocytes 16 , isolated heart 12,58,59 and brain cells 41 compared with NaHCO3 therapy which resulted in ...
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