LATENCY AND REACTIVATION
Clinical Latency and Reactivation of AIDS-Related Mycobacterial Infections
... of latency and reactivation of BCG replication appear to be consistent with the progression to clinical quies- cence and then to the relapse of tuberculosis-like disease in SIVmac-BCG-coinfected ...2. ...
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Liver Sinusoidal Endothelial Cells Are a Site of Murine Cytomegalovirus Latency and Reactivation
... that reactivation could originate only from the transferred ...no reactivation was observed from non-LSEC NPLCs, the frequency of reactivation in the trans- ferred LSEC population was found to be in ...
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Human cytomegalovirus reactivation from latency: validation of a “switch” model in vitro
... the reactivation model at 7 days ...the latency model as a negative control; furthermore, the efficiency of TB40E productive replication upon reactivation was com- pared with that obtained using the ...
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The Role, Mechanism and Transcriptional Regulation of LAT in Herpes Simplex Virus Latency and Reactivation
... HSV reactivation and disease relapse. To reveal the essence of HSV latency and reactivation, we summarized and innovatively classified the role, mechanism and transcriptional regulation of LAT in HSV ...
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Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency in a Cell Type-Specific Manner
... ␥HV68 latency and reactivation raise the question of which cells respond to IFN-␥ to control chronic ␥HV68 ...inhibited reactivation of peritoneal cells and spleen cells harvested from mice lacking B ...
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CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation
... CMV latency and reactivation ...during latency may so far have been underesti- mated as a consequence of CD8 T-cell function having already terminated MIE gene expression in most ...gene ...
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Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation
... of latency in ...viral reactivation (Figure ...viral latency, probably by blocking the a activation in latently-infected mice upon ...for reactivation and eye swabs will be taken at the ...
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... tive reactivation of an HSV-2 mutant with a deletion of the LAT ...which latency and reactivation were not affected by serial interruptions of all predicted ORFs in the major ...influences ...
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Host Cell Gene Expression during Human Immunodeficiency Virus Type 1 Latency and Reactivation and Effects of Targeting Genes That Are Differentially Expressed in Viral Latency
... or latency, some of them have been shown to interact with other ...maintaining latency by modulating certain cellular rep- lication check ...of latency maintenance and reactivation and future ...
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A Myeloid Progenitor Cell Line Capable of Supporting Human Cytomegalovirus Latency and Reactivation, Resulting in Infectious Progeny
... of HCMV biology that will function as a powerful tool to comple- ment current ex vivo model systems. This is the first description of a myeloid cell line that meets all of the criteria for HCMV latency. To our ...
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Epigenetic Histone Modification of Epstein-Barr Virus BZLF1 Promoter during Latency and Reactivation in Raji Cells
... Collectively, our results indicate that two histone modifica- tions, H3K27me3 and H4K20me3, which are associated with the latent EBV BZLF1 promoter region, are at least partly involved in the maintenance of virus ...
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Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants
... vitro latency models. Moreover, to assess the efficacy of such reactivation therapies, we have tested these drugs across a range of conditions, including model virus containing enhancer elements from ...
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MicroRNA miR-155 Is Necessary for Efficient Gammaherpesvirus Reactivation from Latency, but Not for Establishment of Latency
... gammaherpesvirus latency, these studies largely relied on in vitro ...both latency establishment and maintenance occur comparably in the absence of ...setting, reactivation from latency occurs ...
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A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Disrupts the Latency Reactivation Cycle in Calves
... from latency occurs sporadically, resulting in virus shedding and transmission to uninfected ...during latency is the latency-related (LR) RNA, suggesting that it mediates some aspect of ...the ...
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... Rabbit inoculation with HSV-1 and establishment of latency. New Zealand White rabbits (2 to 3 kg) were inoculated with 1 ⫻ 10 5 to 2 ⫻ 10 5 PFU of virus per eye in a suspension of 25 l MEM with 5% FBS. The viral ...
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Latency Related Gene Encoded by Bovine Herpesvirus 1 Promotes Virus Growth and Reactivation from Latency in Tonsils of Infected Calves
... BHV-1 latency, viral genomes are detected in the tonsils of latently infected ...induces reactivation from latency, and viral gene expression is detected in TG and ...the latency-related (LR) ...
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The Mouse Cytomegalovirus Immediate-Early 1 Gene Is Not Required for Establishment of Latency or for Reactivation in the Lungs
... of reactivation in vivo. In the ex vivo reactivation experi- ments, the ⌬ie1 mutant displayed a high incidence of reacti- vation events at 4, 7, and 12 months ...fewer reactivation events for wt MCMV ...
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Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors
... HIV-1 latency similarly to hypothermia in this ...HIV-1 latency, drawing a novel connection between quiescence-induced latency and HSP90 ...modulating latency downstream of hypothermia and ...
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Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents
... HIV reactivation would considerably accelerate decay if the reservoir decays mostly because HIV in latently infected cells reactivates and the cells then ...that reactivation from latency may not be ...
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Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice
... spontaneous reactivation in rabbits and humans, sponta- neous reactivation in the murine model of ocular HSV-1 is rare ...during latency in mice due to the absence of detectable viral protein ...
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