Latent membrane protein 1
Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters
... tent membrane protein 1 (LMP1), LMP2a, EBV nuclear antigen 1 (EBNA1), EBV small nuclear RNA transcripts (EBER), and the BamHI A region transcripts ...of latent membrane ...
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Epstein-Barr Virus Regulates STAT1 through Latent Membrane Protein 1
... viral protein, a limited viral protein expression termed latency ...EBV latent genes—EBNA1, EBNA2, EBNA 3A, EBNA 3B, EBNA 3C, EBNA-LP, latent membrane protein 1 ...
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MUC1 Induced by Epstein-Barr Virus Latent Membrane Protein 1 Causes Dissociation of the Cell-Matrix Interaction and Cellular Invasiveness via STAT Signaling
... that latent membrane protein 1 (LMP1) induces the expression of a series of cellular invasion and metas- tasis factors, such as matrix metalloproteinase 9 (MMP9), which plays a critical role ...
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Global Proteomic Changes Induced by the Epstein Barr Virus Oncoproteins Latent Membrane Protein 1 and 2A
... oncoproteins latent membrane protein 1 (LMP1) and LMP2A constitutively activate multiple signaling pathways, and both have been shown to interact with cellular ubiquitin ligases and affect ...
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EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas
... EBER 1 and 2 (Epstein-Barr encoded RNA) and a nuclear protein called EBNA1 (Epstein-Barr nuclear antigen 1) detected in all NPC biopsies and visualized in the major- ity of malignant ...EBV ...
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Maintenance of Epstein-Barr Virus Latent Status by a Novel Mechanism, Latent Membrane Protein 1-Induced Interleukin-32, via the Protein Kinase Cδ Pathway
... EBV latent membrane protein 1 (LMP1) is responsible for inducing IL-32 expression at the mRNA and protein ...activator protein kinase C␦ (PKC␦) and inhibits its translocation ...
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Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.
... (EBV) latent membrane protein 1 (LMP-1) oncogene is regulated by the EBV nuclear protein 2 (EBNA-2) ...DNA-binding protein J k and is recruited to promoters containing the ...
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Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1
... antigen 1 (EBNA-1) in ...EBV latent membrane protein 1 (LMP-1) and that LMP-1 stimulates the expression of IRF-7 in type III latency in which Qp is ...
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Latent Membrane Protein 1 of Epstein-Barr Virus Inhibits as Well as Stimulates Gene Expression
... The latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) functionally resembles a constitutively active, CD40-like receptor and contributes to the maintenance of proliferation ...
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Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation
... antigen 1 (EBNA1) protein is required for tethering EBV episomes to cellular DNA and for mitotic segre- gation to daughter ...EBV latent membrane protein 1 (LMP1) is an onco- ...
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Tumor Suppressor p53 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1
... ABSTRACT Epstein-Barr virus (EBV) is associated with multiple human malignancies. EBV latent membrane protein 1 (LMP1) is required for the efficient transformation of primary B lymphocytes in ...
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Induction of Epstein-Barr Virus Latent Membrane Protein 1 by a Lytic Transactivator Rta
... Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signaling pathways and contributes to EBV-associated ...lytic ...
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The Epstein-Barr virus latent membrane protein 1 regulates gene expression by engaging multiple signaling pathways
... Primary infection of EBV, through oral transmission during childhood, is normally asymptomatic. However, if the primary infection is delayed until adolescence or early adulthood, half of the patients develop benign ...
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Oncogenic Activity of Epstein-Barr Virus Latent Membrane Protein 1 (LMP-1) Is Down-Regulated by Lytic LMP-1
... effect was not due to a loss of transient LMP-1 expression. It was shown by the luciferase promoter studies that LMP-1 signaling activation is significantly inhibited by a 10:1 lyLMP- ...
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Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Activates the JNK Pathway through Its Extreme C Terminus via a Mechanism Involving TRADD and TRAF2
... (aa 1 to 79) as the substrate (third panel), and HA-JNK levels (fourth ...at 1 mg following a longer exposure of the ...with 1 mg of pcDNA3-CD40 or control vector in the presence of increasing ...
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Overexpression of Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in oral squamous cell carcinoma
... 10 min in 10 mM citrate buffer pH 6.0. They were then washed in phosphate buffered saline (PBS), covered by 5% bovine serum albumin (Sigma-Aldrich) for 30 min. Sections were treated with primary antibody for 2 h in a ...
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Epstein-Barr virus leader protein enhances EBNA-2-mediated transactivation of latent membrane protein 1 expression: a role for the W1W2 repeat domain.
... Figure 1A shows typical results obtained with the Eli-BL cell line. Transfection of the EBNA-2 vector alone produced de- tectable amounts of EBNA-2 protein and led to a clear up- regulation of LMP1 expression, ...
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Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A
... FoxO1 protein detected was capable of binding DNA, it was then important to determine whether DNA bind- ing initiated transcriptional activation and to measure the ef- fect of EBV on target gene ...Bcl-6 ...
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The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor.
... LMP1 protein is an important component of the process of trans- formation by ...the protein and mRNA ...of protein extracts from nude mouse-passaged NPC tumors also demonstrated that the EGFR is ...
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Transmembrane Domains Mediate Intra- and Extracellular Trafficking of Epstein-Barr Virus Latent Membrane Protein 1
... with 1 ⫻ PBS to remove excess medium and recentrifuged at 500 ⫻ g for 5 ...NaCl, 1 mM EDTA, 1% Nonidet P-40, ...plus 1 ⫻ HALT protease inhibitor (Thermo Scientific; number 78429), Phosphatase ...
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