latent membrane protein 2A
Epstein-Barr Virus Latent Membrane Protein 2A Contributes to Anoikis Resistance through ERK Activation
... E pstein-Barr virus (EBV) is a ubiquitous human herpesvirus that infects more than 90% of the world’s populations. EBV infection is associated with a variety of malignancies, including endemic Burkitt’s lymphoma, ...
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Epstein-Barr Virus Latent Membrane Protein 2A Promotes Invasion of Nasopharyngeal Carcinoma Cells through ERK/Fra-1-Mediated Induction of Matrix Metalloproteinase 9
... Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is highly metastatic, and this malignant feature may be promoted by an EBV oncoprotein, latent membrane protein 2A (LMP2A). ...
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Tyrosine 112 of Latent Membrane Protein 2A Is Essential for Protein Tyrosine Kinase Loading and Regulation of Epstein-Barr Virus Latency
... Latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) is expressed on the plasma membrane of B lymphocytes latently infected with EBV and blocks B-cell receptor (BCR) signal ...
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Roles of the ITAM and PY Motifs of Epstein-Barr Virus Latent Membrane Protein 2A in the Inhibition of Epithelial Cell Differentiation and Activation of β-Catenin Signaling
... Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A) is important for maintenance of latency in infected B lymphocytes. Through its immunoreceptor tyrosine-based activation motif (ITAM) ...
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Epstein-Barr Virus (EBV) Latent Membrane Protein 2A Regulates B-Cell Receptor-Induced Apoptosis and EBV Reactivation through Tyrosine Phosphorylation
... lifelong latent infection of B ...that latent membrane protein 2A (LMP2A) inhibited B-cell receptor (BCR)-induced apoptosis in Burkitt’s lymphoma cell ...tyrosine-specific ...
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Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn
... Latent membrane protein 2A (LMP2A) is a viral protein expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in ...
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Latent Membrane Protein 2A-Mediated Effects on the Phosphatidylinositol 3-Kinase/Akt Pathway
... (EBV) latent membrane protein 2A (LMP2A) is expressed on the membranes of B lymphocytes and blocks B-cell receptor (BCR) signaling in EBV-transformed B lymphocytes in ...The protein ...
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Epstein-Barr Virus Latent Membrane Protein 2A Mediates Transformation through Constitutive Activation of the Ras/PI3-K/Akt Pathway
... (EBV) latent membrane protein 2A (LMP2A) is widely expressed in EBV-infected cells within the infected human host and EBV-associated malignancies, suggesting that LMP2A is important for EBV ...
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K1 and K15 of Kaposi's Sarcoma-Associated Herpesvirus Are Partial Functional Homologues of Latent Membrane Protein 2A of Epstein-Barr Virus
... viral protein latent membrane protein 2A (LMP2A), which can functionally replace the BCR because Ig-negative B cells can only survive if infected with EBV but not with an LMP2A-negative ...
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Epstein-Barr Virus Latent Membrane Protein-2A Induces ITAM/Syk- and Akt-Dependent Epithelial Migration through αV-Integrin Membrane Translocation
... To compare LMP2A-induced wound healing with chemoat- tractant-directed migration, epithelial cells were induced to mi- grate for 24 h to FBS, collagen, and fibronectin. HFK pBabe con- trol cells migrated efficiently to ...
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Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction.
... coupling membrane-proximal signaling events with downstream events (34, 35), but there is no evidence to suggest they have a role in the induction of tyrosine phosphor- ylation following receptor ...a ...
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Epstein-Barr Virus Latent Membrane Protein 2A Regulates c-Jun Protein through Extracellular Signal-Regulated Kinase
... the protein was resolved by sodium dodecyl sulfate–8% polyacrylamide gel electrophoresis and blotted onto a polyvinylidene difluoride nitrocellulose membrane (Millipore, Bedford, ...
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Role of the Immunoreceptor Tyrosine-Based Activation Motif of Latent Membrane Protein 2A (LMP2A) in Epstein-Barr Virus LMP2A-Induced Cell Transformation
... LMP2A protein-protein interaction motifs may interact with other protein kinases in the cells or that multiple interac- tions of LMP2A with protein kinases may be necessary for ac- tivation of ...
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Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling
... FIG. 5. Tyrosine phosphorylation of LMP2A, Lyn, and Syk in bone marrow cells cultured in IL-7-containing methylcellulose medium. Tri- ton X-100 lysates from methylcellulose-cultured bone marrow B cells were subjected to ...
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The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer
... Several lines of evidence indicate that LMP2A may activate the PI3-K/Akt pathway through protein kinase Syk and Lyn, which play a crucial role in cell survival [130]. It was observed that LMP2A-associated ...
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Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes.
... BJAB cell lines expressing LMP2A, LMP1, LMP2A and LMP1, or vector controls were treated with antibodies to human class II or CD19 and their intracellular free calcium levels were monitor[r] ...
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Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A
... gets FoxO1 molecules for nuclear exclusion and thus would not be easily detected by this assay. Acetylation of nuclear FoxO proteins has also been reported to affect the transcriptional programs controlled by FoxO ...
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Two Pathways of p27Kip1 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A
... In order for naive B cells to become memory B cells, they undergo clonal expansion following antigen exposure and form germinal centers (GC) in the spleen and lymph nodes (5, 6). While in the GC, antigen binding to the B ...
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Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer
... X protein; EBV: Epstein-Barr virus; LMP-1: Latent membrane protein 1; LMP-2A: Latent membrane protein 2A; EBER-1: EBV encoded small RNAs-1; EBER-2: EBV ...
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Global Proteomic Changes Induced by the Epstein Barr Virus Oncoproteins Latent Membrane Protein 1 and 2A
... oncoproteins latent membrane protein 1 (LMP1) and LMP2A constitutively activate multiple signaling pathways, and both have been shown to interact with cellular ubiquitin ligases and affect cellular ...
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