Lead compound
In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models
... discovered lead compound ...the compound appeared to be equally efficacious on drug-resistant and drug-sensitive parasite ...new lead compound with an attractive antimalarial ...
8
Biological activities of nitidine, a potential anti malarial lead compound
... This detailed study of the anti-plasmodial activity of niti- dine showed that this known anti-plasmodial molecule, which is present in several traditional anti-malarial reme- dies, can be considered an interesting ...
8
In vitro and in silico Analysis to Identify Novel Lead Compound from Morinda tinctoria fruit Against Breast Cancer
... The affinity level and distance between the receptor and ligand molecule was calculated in 9 different modes using AutoDock Vina molecular docking software to get the best docking pose. The docking has been performed ...
6
Pradimicin A, a Carbohydrate-Binding Nonpeptidic Lead Compound for Treatment of Infections with Viruses with Highly Glycosylated Envelopes, Such as Human Immunodeficiency Virus
... Time-of-drug-addition experiment with GFP-expressing HIV-1/NL4-3.GFP11. The time-of-drug-addition experiments have been previously described (11). Briefly, C8166 cells were infected with HIV-1/NL4-3.GFP11. Following a ...
12
Direct and indirect approaches to identify drug modes of action
... following lead compound identification by phenotypic screening; lead compounds identified through target-based screening seldom bind solely to the target screened against and it is prudent to ...
17
The Design and Synthesis of 2-Aminoimidazole Biofilm Modulators.
... the lead compound of the “parent” library, the new 2-AI small molecules maintained antibiotic activity in addition to being able to disperse Gram-negative ...
254
Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives
... a lead compound, the introduction of the active groups onto the A- ring, and the modification of the carboxyl group at the C-28 position using esterification or amidation, twenty new Oleanolic acid ...
16
“SYNTHESIS AND PHARMACOLOGY OF NOVEL ANTIDEPRESSANT AGENTS WITH DOPAMINE AUTORECEPTOR AGONIST PROPERTIES” by Nandini R. Pai*, Deepnandan S. Dubhashi, Diptanshu A. Pusalkar, India.
... the lead compound “6” but when the substituent positions are altered to R3 and R4 as in compound “6d” shows no potency with ED 50 ...the compound “6e” the introduction of more bulky bromine ...
12
Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen Combretastatin and Cyclofenil Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
... Abstract: Nuclear receptors such as the estrogen receptors (ER α and ER β ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as ...
50
Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2
... a lead compound for molecular infer- ence in the HOTAIR/EZH2 scaffold interaction and tar- geted HOTAIR therapy ...the lead compound due to its desirable potency and physicochemical ...
16
MOLECULAR DOCKING STUDIES OF PHYTOCHEMICALS AGAINST Leishmania donovani TRYPANOTHIONE REDUCTASE
... potential lead compound by virtual screening, capable of inhibiting the target protein Trypanothione reductase ...suitable lead compound against ...potential lead compound ...
5
Computational screening of phytochemicals for finding potential inhibitor against C/EBPβ and PPARγ
... Computational screening methodologies are widely recognized as efficient approaches in initial phases of drug discovery. Virtual screening is an emerging and effective approach to computationally analyse the large ...
9
Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380
... We have recently developed a novel anticancer agent, designated NSC-743380, through chemical library screening of isogenic cells with or without a mutant KRAS gene [19] and through lead compound ...
10
Design, Synthesis, Characterization and Biological Evaluation of Some Novel Heterocyclic Derivatives as Anti Tubercular Agents Targeting L, D Transpeptidase 2
... Aim and plan of work The present study was carried out based on the below flow chart Finding the HIT compound Identification of the lead compound from the HIT Lead optimization Docking o[r] ...
105
MOLECULAR DOCKING STUDIES OF CHROMENE ANALOGUES ON TRYPANOTHIONE REDUCTASE FOR TARGETING LEISHMANIASIS
... The compound 11, 12 and 14 have the valid MolDock Score ...test. Compound 14 was found to be most effective as compared to rest two compound (11 & ...the compound 14 and amino acids ...
15
4-(quinoxalin-6-yl) pyrazoles as selective ALK5
... ADMET properties of good targeted compounds 16e–h as drug lead compound were predicted 614. using ADMET descriptors in Discovery Studio 2017 (Accelrys, San Diego[r] ...
20
Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
... the lead pyrrolo [2,3-d] pyr- imidine inhibitors ...the lead molecules as cell-based in- hibitors vis á vis isolated enzymes suggested an importance of cellular transport and ...the lead ...
12
Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
... In this study, we found that HSP90β, rather than HSP90α, is clinical relevant to lipid dysregulation in NAFLD patients and animal models. It was demonstrated that HSP90β is vital in regulating fatty acid and cholesterol ...
15
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis
... Simple animal models of ALS are powerful tools for therapeutic discovery of compounds that suppress disease phenotype, regardless of the specific molecular targets (21). We previously developed C. elegans (22) and ...
21
Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin
... A new class of N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide inhibitors of influenza virus hemagglutinin (HA)-mediated membrane fusion that has a narrow and defined structure-activity relationship was identified. In ...
12