lead compounds
Computational Studies and Molecular Dynamic Simulation to Design Lead Compounds for Hepatitis B Virus
... sist derivates of bis (L-amino acid) ester prodrugs of 9-[2-(phosphono- methoxy)ethyl] adenine (PMEA), Lamivudine and Adefovir dipivoxil with IC 50 value. To validate the simulation model, that compounds ware used ...
5
4 Cyano 1,3 oxazole 5 sulfonamides as Novel Promising Anticancer Lead Compounds
... Results of the initial single dose (10 μM) testing of NSC 765529, NSC 765530, NSC 762255, NSC 762256, NSC 762257, NSC 762258 and NSC 762259 against the 60 cell lines of NCI are presented as one dose mean graphs of the ...
16
MOLECULAR MODELLING AND MOLECULAR DYNAMICS STUDIES OF SPECT PROTEIN OF PLASMODIUM FALCIPARUM AND IN SILICO SCREENING OF LEAD COMPOUNDS
... Ligand Preparation: A library of 2,76784 biogenic compounds from ZINC database, a freely available database of commercially available compounds, was chosen for screening. This library is composed of ...
11
Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by <em>Pseudomonas aeruginosa</em> in cystic fibrosis patients: in vitro and in vivo studies
... Aim: In the present work, the potential of the D-enantiomeric dendrimers dG3KL and dTNS18 was evaluated in relation to tobramycin (Tob), for the development of novel antibacterials to [r] ...
16
IN VITRO ANTIMICROBIAL ACTIVITY OF SELECTED MEDICINAL PLANTS IN LOSHO, NAROK COUNTY KENYA
... Bioactivity of organic and aqueous extracts of S. alata, O. kirkii, C. holstii and H. forskahlii on bacterial and fungal strains is noteworthy. From this study H. forskahlii is a better source of antimicrobial agents and ...
5
Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors
... The binding pocket was determined by various crystal- line structures and binding site prediction servers. A total of 30 ligands with high binding affinities for NS5B were obtained. The docking scores were represented ...
17
New structure–activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity
... Original data about ABCG2 inhibitory sites and molecular mechanism have been obtained in the present work, thanks to a wide variety of chalcones and derivatives. Firstly, the flavonoid-specific inhibitory site appeared ...
10
Direct and indirect approaches to identify drug modes of action
... following lead compound identification by phenotypic screening; lead compounds identified through target-based screening seldom bind solely to the target screened against and it is prudent to ...
17
COMPARATIVE MODELING OF PLASMODIUM FALCIPARAM DIHYDROPTEROATE SYNTHASE 2 AND DOCKING STUDY AGAINST COMPOUNDS FROM ANTI-MALARIAL PLANT CARCIA PAPAYA AND SWERTIA CHIRATA
... Malaria parasite Plasmodium falciarum are becoming drug resistant and the present drugs are becoming ineffective towards the disease. The Plasmodium falciparum causes the most malignant form of malaria highly prevalent ...
6
Gc-Ms Analysis And In Silico Docking Analysis Of Extracts Of Acacia Torta Craib
... the compounds present in the sample. Then, lead compounds were screened to be used for docking with ...the lead compounds against the human penicillin binding protein to check their ...
5
Novel naphthoquinone analogs that target Wnt/β Catenin/TCF4 signaling pathway and clonogenic activity of colon carcinoma cells
... al., 2013; Lepourcelet et al., 2004; Wei et al., 2010; Handeli et al., 2008; Saraswati et al., 2010; Watanabe et al., 2011; Lepourcelet et al., 2004; Barker and Clevers, 2006; Lu et al., 2004) Most of these ...
11
AN EXPLAINING THEORY FOR DIURETIC-INDUCED-DIABETES INCIDENCES
... Bendroflumethiazide, and Metolazone bind to the same pocket as GBM, while the other members bind to a close binding site to GBM pocket. These results add a new explanation of why these Chlorthalidone and ...
13
Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson’s disease: a pharmacoinformatics study
... potent lead compounds for PD treatment. The compounds were also assessed for their ADMET ...potential compounds that should be scrutinized for use against PD as potent ...two compounds ...
12
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents
... poor aqueous solubility, with a reported clogP of 5.322, 12 and as well as affecting its pharmacokinetics this may cause it to accumulate in membranous compartments of the parasite and its host erythrocyte, away from its ...
12
Basim T Al-Rekabi* and Jassim E Q Almusawi**
... the lead acetate toxicity and the collaboration of thiamine (vitamin B1) in calming of these changes in male rabbits ...reserved lead acetate (5 mg/kg ...with lead acetate (5 mg/kg ...of lead ...
6
Modulatory effect of Cardiospermum halicacabum extracts on TLR-2 in PBMC cells
... Cardiospermum halicacabum leaves extract were investigated for their effect on expression of toll like receptor 2 (TLR-2) in Peripheral Blood Mononuclear Cells (PBMC) of healthy individual. Cell viability was not ...
6
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition
... Lead compounds are used in different industries world- wide due to their chemical and physical characteristics ...the lead is its reactions with acids and bases as well as with air, which are ...
6
A REVIEW: LEAD TOXICITY AND IT’S MEDICOLEGAL ASPECTS
... x-ray. Lead toxicity associated with IQ deficits, behaviour disorders, slowed growth, and impaired ...of lead poisoning continue to ...However, lead compounds can act by producing spasms of ...
5
Design and Analysis of Novel Inhibitors Against the Kras Mutations in Lung Cancer Through Computer Aided Drug Designing Techniques
... effective compounds against KRAS protein involved in Lung ...research, lead compounds against the KRAS mutations were identified through pharmacophore modeling and virtual screening approach and then ...
12
20. Revealing potential drug targets against Proto-oncogene Wnt10B by comparative molecular docking
... 20 compounds from docking through AD-VINA (with respect to binding energy values) and GOLD (goldscore values) were selected and critically ...20 compounds, three compounds were found common in both ...
10