leptin deficiency
Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice
... functions, leptin also plays an important role in innate and adaptive immune ...responses. Leptin can induce TNF-a and IL-6 production by monocytes [20]. Leptin can also augment the ability of ...
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Original Article Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice
... Leptin is known to promote the synthesis and secretion of endothelin-1 in human umbilical vein endothelial cells [20], and promotes the expression of preproendothelin-1 and endothe- lin ET A receptor, ...
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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
... of leptin deficiency on both the hypothalamic-pituitary-adrenal axis and on linear growth ...of leptin deficiency on these endocrine functions in humans, in contrast with ...by leptin ...
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Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency
... LPL is found in large amounts in heart, skeletal muscle, and adipose tissue, but it is also present in kid- neys, lungs, fetal liver, lactating mammary gland and macrophages, as well as in scattered cells of the brain ...
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Delayed resolution of acute inflammation during zymosan induced arthritis in leptin deficient mice
... findings, leptin deficient mice are protected from inflamma- tion mediated by T and B cells in different disease models, including AIA, experimental autoimmune encephalomyelitis, type 1 diabetes and experimental ...
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Leptin as a Modulator of Neuroendocrine Function in Humans
... addition, leptin plays a significant permissive role in the physiological regula- tion of several neuroendocrine axes, including the hypothalamic-pituitary-gonadal, -thyroid, -growth hormone, and -adrenal ...of ...
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Leptin and the leptin receptor : Molecular and genetic studies
... that leptin levels increase throughout puberty, in response to increasing fat mass (Clayton et ...boys, leptin appears to increase until Tanner stage 2 of puberty when the testosterone surge occurs, ...
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Monogenic forms of childhood obesity due to mutations in the leptin gene
... congenital leptin deficiency when they show impaired satiety, intense hyperphagia, and food-seeking behavior (see Clinical phenotype of pa- tients with congenital leptin deficiency) ...
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The role of leptin in innate and adaptive immune responses
... of leptin on lymphocytes are thus not necessary for T cell maturation and immune response in a normal ...the leptin receptor in the systemic and/or local environment is mandatory for T cell ...of ...
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New advances in the treatment of generalized lipodystrophy: role of metreleptin
... human leptin or metreleptin is a synthetic leptin analog that has been trialed in patients with leptin-deficient conditions, such as leptin deficiency due to mutations in the ...
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Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
... DGAT1 deficiency on fur and sebaceous ...with leptin deficiency, indicating an unexpected role for leptin in modulating the skin ...that leptin modulates these processes in the ...
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
... PTP1B deficiency rather than a direct loss of gene/protein ...PTP1B deficiency be changing developing feeding/metabolic circuits, resulting in the observed phenotypes? Moreover, can one produce metabolic ...
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Sixteen years and counting: an update on leptin in energy balance
... hormone leptin, which is produced and secreted by white adipose ...discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose ...fluxes. Leptin ...
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Short Term International Study For Teachers As A Form of Experiential Learning: A Case Study of American Educators in Turkey
... of leptin- mediated upregulation of NADPH oxidase and increased expression of microRNA 21 (miR21) in hepatic ...p47phox, leptin and miR21 were used to prove the role of the leptin-NADPH oxidase-miR21 ...
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OBESITY, INFLAMMATION AND METABOLIC SYNDROME
... serum leptin, TNF- α were measured using ELISA methods and serum triglycerides, cholesterol and lipid profile in normal and overweight BMI subjects were ...Interestingly leptin level was found to be higher ...
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Phocid seal leptin : tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution
... divergent leptin gene and dive to great ...phocid leptin. The function of leptin in the lung of the foetus is to provide additional surfactant when the lungs need to fill with air for the first time ...
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Original Article Leptin induces partial epithelial-mesenchymal transition in a FAK-ERK dependent pathway in MCF10A mammary non-tumorigenic cells
... of leptin-induced changes in EMT markers. Our data show that leptin induces the activation of both FAK and ERK kinases, and that leptin-induced migration of MCF10A cells is dependent on the ...
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Effect of Plasma-leptin on Cardiac Disorders with Type 2 Diabetes-patients
... soluble leptin receptors level showed the tendency of being related to visceral fat area (r = ...fact, leptin was related to standard deviations of NN (normal RR) intervals during the 24-hour period (r = ...
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Leptin inhibits 4 aminopyridine– and pentylenetetrazole induced seizures and AMPAR mediated synaptic transmission in rodents
... that leptin receptor activation in other neuronal subtypes would have anticonvulsant activity and that intranasal leptin delivery would be an effective route of ...and leptin. In mice, intranasal ...
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Circulating omentin concentration increases after weight loss
... circulating leptin were significantly higher than in men ...circulating leptin and baseline circulating omentin-1 may explain the sex differences in omentin-1 concentration in this ...
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