Leptin Receptor
Leptin receptor gene polymorphisms and morbid obesity in Mexican patients
... Background: Human obesity is due to a complex interaction among environmental, behavioral, developmental and genetic factors, including the interaction of leptin (LEP) and leptin receptor (LEPR). ...
5
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
... The 223R allele of the leptin receptor increases sus- ceptibility to intestinal amebic infection and mucosal destruction in the murine model of intestinal amebia- sis. (A) Mice carrying 1 or 2 copies of the ...
9
Evaluation of the leptin receptor in human spermatozoa
... rodents, leptin receptor (ObR) mRNA is expressed in the Sertoli cells of adult rats [20] while leptin receptor immunoreactivity is confined to the Leydig cells of rats and the germ cells of ...
7
Selective deletion of leptin receptor in neurons leads to obesity
... The leptin receptor, which has five splice variants (ObRa–e), is broadly expressed, however, and the relative importance of leptin’s effects on brain versus peripheral sites is unclear (18, ...because ...
10
Leptin receptor gene as a genetic marker for leanness in pigs
... Disclosed herein are genetic markers for pig leanness, methods for identifying such markers, and methods of screening pigs to determine those more or less likely to be obese and more or less likely to produce litters ...
15
Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers
... that leptin is involved in local and systemic inflammation of smoker and former smoker COPD patients, matched for age, gender, pulmonary function, and BMI and body ...the leptin/leptin ...
9
Sexual maturation in hens is not associated with increases in serum leptin and the expression of leptin receptor mRNA in hypothalamus
... addition, leptin may act as a meta- bolic signal involved in the control of the onset of sexual maturation and reproduction via leptin receptor in hypothalamus to activate GnRH ...the leptin ...
7
Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia
... expenditure. Leptin is a hormone synthesized mostly by white adipose ...of leptin depend directly on adipose tissue mass and correlate with body mass index (BMI) ...of leptin are mediated by ...
9
Differential Expression of Leptin and Leptin Receptor mRNA in Obese and Non Obese Women across the Menstrual Cycle Title
... that leptin, the product of the obese (ob) gene, which is synthesized and secreted ex- clusively by adipose tissue, provides a signal regulating the total mass of body fat ...serum leptin levels are ...
10
Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population
... [4]. Leptin exerts its physiological effect by binding to leptin receptor, a single transmembrane protein which belongs to class I cytokine receptor ...Upon leptin binding to its ...
10
PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction
... in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including ...insulin receptor (InsR) downstream of leptin ...in leptin ...
20
Monitoring the Expression of Leptin Receptor in Avian Model
... length leptin receptor fragment located in the expected ...of leptin receptor fragment, showed that its length did not correspond to the expected length of the fragment bounded by the proposed ...
6
Leptin levels and leptin receptor polymorphism frequency in healthy populations
... of leptin have been shown to cor- relate with obesity [2], a known risk factor for postmenopausal breast cancer ...that leptin stimulates the proliferation of normal and malignant breast epithelial cells ...
6
Leptin and the leptin receptor : Molecular and genetic studies
... of leptin on the human endometrium were ...for leptin within the human endometrium was the identification of leptin receptor iso form ...the leptin receptor were present in ...
243
NO ASSOCIATION OF THE LEPTIN (RS17151919) AND LEPTIN RECEPTOR (RS3790434) GENE POLYMORPHISMS WITH IRRITABLE BOWEL SYNDROME IN TURKISH POPULATION
... for leptin (LEP) (rs17151919) (G>A) and leptin receptor (LEPR) (rs3790434) (G>A) genes using a TaqMan SNP genotyping assay in the 7500 Real-Time PCR System (Applied Biosystems, Foster City, CA, ...
7
Leptin and leptin receptor polymorphisms are associated with poor outcome (death) in patients with non appendicular secondary peritonitis
... LEP: leptin; LEPR: leptin receptor; LPS: lipopolysaccharide; MOF: multiple organ failure; MPI: Mannheim Peritonitis Index; OR: Odds ratios; PCR: polymorphism chain reaction; RFLPs: restriction ...
8
Variability in the leptin, leptin receptor and heart fatty acid binding protein genes in relationship with meat quality traits in pigs
... The leptin (LEP-HinfI), leptin receptor (LEPR-HpaII) and heart fatty acid binding protein (H-FABP- HinfI) genes and their genotypes combination (LEP-HinfI *LEPR-HpaII) were tested for associations ...
8
Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica Infection
... The leptin receptor mutation resulted in an intrinsic defect in neutrophil chemotaxis to ...the leptin receptor (30), neutrophils have been shown to migrate toward leptin (27, 31, ...
8
Intermittent Hypoxia Affects Leptin and Leptin Receptor Signaling in the Rat Carotid Body
... both leptin and the Ob-R’s are altered during IH during the time plasma levels of leptin are elevated by ...that leptin, either through an autocrine/paracrine mechanism or from other sources that ...
202
Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants
... of leptin and sOB-R were kept at -70°C until measurement. Plasma leptin and sOB-R were measured using the commercial enzyme linked immunoassay kits from the same manufacturer (Diagnostic Systems ...
7