leptin signaling
Next Generation of Spontaneously Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop Cardiac Dysfunction and Compromised Cardiac Reserve
... characterized for phenotypes of cardiomyopathy [20]. Ob/ob and db/db mice develop obesity and diabetes from age of 6-8 weeks old as a result of recessive mutation of obesity gene, leptin and defects in ...
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Leptin signaling molecular actions and drug target in hepatocellular carcinoma
... high leptin levels in obesity and in overweight individuals or popula- ...High leptin level is a hallmark of obesity, which has been correlated to the incidence and progression of several malignancies ...
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Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer
... of leptin in EOC cells ...of leptin signaling in the pathogenesis of EOC ...of leptin/Ob-R with antiapoptotic signaling including PI3K/ AKT and MAP kinase [32, 34, 38, 40, 58, ...
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Endurance exercise is a leptin signaling mimetic in hypothalamus of Wistar rats
... circulating leptin was decreased significantly by the endurance ...plasma leptin levels may favor the peripheral action of leptin through the hypothalamic centers ...plasma leptin levels is ...
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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
... in leptin levels such as those caused by food deprivation ...availability, leptin signaling through alternative pathways such as STAT3 (9) or SH2-containing tyrosine phosphatase (44) predomi- nate in ...
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
... to leptin single mutants, suggesting that the metabolic effects of PTP1B deficiency may also involve non-leptin signaling ...enhanced leptin signaling remains ...of leptin ...
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Insights into the putative role of leptin in various traversing stages of women: A narrative review
... and leptin and also the maturation of kisspeptin neurons Suprachiasmatic nucleus (SCN) is a part of the hypothalamus which is called master clock of the body to regulate puberty (Beymer et ...between leptin ...
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Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
... and leptin signaling (Table 3), and differentially expressed genes encoded proteins involved in immunity and inflam- mation, cell growth and proliferation, fat metabolism and ...
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Role of leptin and melanocortin signaling in uremia associated cachexia
... by leptin signaling through the hypothalamic melanocortin receptor 4 ...WT, leptin receptor–deficient (db/db), and MC4-R knockout (MC4-RKO) ...Corrected leptin levels were ...as leptin ...
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Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling
... of leptin. Here we examined hypothalamic signaling pathways engaged by leptin to upregulate TRH gene ...by leptin-induced expression of suppressor of cytokine signaling–3 (SOCS-3) in ...
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Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice
... of leptin in regulating lipid metabo- lism and islet function/growth (28, ...absent leptin signaling and is one pos- sible mechanism underlying the impaired glucose tolerance in the pancreas-ObR-KO ...
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Leptin dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction
... LepR signaling in the preop- tic region, we used stereotaxic techniques to deliver a TAT-Cre recombinant protein to LepR floxed ...which leptin activates nNOS (16), increased basal LH release, suggesting ...
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Leptin promotes melanoma tumor growth in mice related to increasing circulating endothelial progenitor cells numbers and plasma NO production
... a leptin receptor antagonist [28]revealed that leptin signaling promotes the growth of some types of mam- mary tumors and increases the expression of proliferating cell nuclear antigen, cyclin D1, ...
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PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction
... in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including ...leptin signaling. We show that disruption of p110a and p110b subunits in ...
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Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
... Leptin signaling in Kiss1 neurons is not required for puberty and ...of leptin-induced pSTAT3 in Kiss1 neurons of the Arc; (C) quantification of Kiss1 neurons expressing leptin-induced pSTAT3 ...
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Short Term International Study For Teachers As A Form of Experiential Learning: A Case Study of American Educators in Turkey
... targets leptin induced TLR4 trafficking in Kupffer ...adipokine leptin regulates Kupffer cell activation via reactive oxygen species ...generation(40). Leptin increased peroxynitrite generation by ...
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Fertility in classical galactosaemia, a study of N-glycan, hormonal and inflammatory gene interactions
... ALG9 : Alpha-1,2-Mannosyltransferase; AMH: Anti Mullerian Hormone; ANXA1 : Annexin A1; B4GALT : UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase; cDNA: Complimentary Deoxyribonucleic acid; CV: Coefficient of Variance; ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... JAK2/STAT3 signaling pathway in humans with acute pancreatitis (AP) is yet ...JAK2/STAT3 signaling pathway including serum free fatty acid (FFA), leptin, p-JAK2, and p-STAT3 were investigated to ...
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FOXO1 in the ventromedial hypothalamus regulates energy balance
... Defective regulation of energy balance results in obesity and com- ponents of metabolic syndrome, such as type 2 diabetes. Under- standing the molecular and cellular mechanisms underlying the ability of the central ...
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Thesis.pdf
... between leptin and T cells alone, we utilized a T cell specific leptin receptor conditional knockout (KO) mouse in which leptin receptor (LepR) has been truncated in T cells ...
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