leucine-rich repeat
LRT, a tendon specific leucine rich repeat protein, promotes muscle tendon targeting through its interaction with Robo
... a leucine-rich repeat domain, a transmembrane domain and a small cytoplasmic domain at its C- terminal end, suggesting that it is a type I transmembrane domain protein ...product ...
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Point mutation in a leucine rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard Soulier syndrome
... expressed recombinant GP Ib alpha fragments to demonstrate that the observed mutation is the cause of defective von Willebrand factor binding. These studies define the molecular basis of the Bernard-Soulier syndrome ...
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Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... mosquito leucine-rich repeat immune proteins in ...60 leucine-rich repeat related transcriptions in response to ZIKV (Accession number: GSE118858, ...
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Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... Supplementary Materials: Table S1 : Female Aedes aegypti transcriptomic RNA-seq data show Leucine- Rich Repeat Proteins 7-days post infection or post injection between Key west and Orl[r] ...
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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
... In 2002 Funayama and collaborators reported a new genetic linkage to dominant inherited PD [51]. Two years later, independent groups not only described addi- tional families with linkage at the same chromosomal locus but ...
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Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells
... that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem ...
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Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry
... supplementary domains [5,8,14]. One family of brain- enriched LRR containing type I transmembrane proteins is termed the LRRTM (leucine rich repeat transmembrane neuronal) family [8]. This is a ...
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The fibronectin leucine rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis
... known leucine-rich repeat cell-surface proteins failed to detect interactions between the Flrt paralogues and members of the Fgfr family (Sollner and Wright, ...
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A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine-rich repeat domains (FIGLER)
... cytokine receptors, the predicted FIGLER molecules have a unique domain structure, marked by the N-terminal LRRs and an unusual genomic organization. Two previ- ously described molecules that combine LRR, Ig and FNIII ...
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Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... a leucine rich repeat domain (LRR, 65-209) which harbors 6 plant-specific LRRs, an LRR C-terminal domain (CT, 210-249), a transmembrane domain (TM, 250-270), and an intracellular kinase domain (KD, ...
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Original Article Leucine-rich repeat neuronal protein 4 (LRRN4) potentially functions in dilated cardiomyopathy
... that leucine-rich repeat protein played an important role in cardiac remodeling [10] and cardiac contractile function maintaining ...between leucine-rich repeat containing ...
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The small leucine rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway
... Small leucine-rich repeat proteoglycan (SLRP) family proteins play important roles in a number of biological events. Here, we demonstrate that the SLRP family member Asporin (ASPN) plays a crucial ...
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Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
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The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... for leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of both familial and sporadic forms of ...domains: leucine-rich repeats, Ras-like GTPase domain, C-terminal of ...
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Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease
... We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated ...
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The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression.
... The CCR4 Protein From Saccharomyces cerevisiae Contains a Leucine-Rich Repeat Region Which Is Required for Its Control of ADH2 Gene Expression.. Thomas Malvar,* Rachel W.[r] ...
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Leucine-rich repeat and sterile alpha motif containing 1 promotes the oncogenic growth of human hepatocellular carcinoma cells
... worldwide. Leucine-rich repeat and sterile alpha motif containing 1 (LRSAM1) is an E3 ubiquitin ligase involved in diverse cellular activities, including the regula- tion of cargo sorting, cell ...
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An Arabidopsis thaliana leucine rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens
... site-leucine-rich repeat (NBS-LRR) family, which are involved in disease resistance and are believed to bind to pathogen-associated proteins (McHale et ...
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Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein
... In! ,I, I)c,', Bioi, ~O 5~5 555 (t996) 545 Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein REGINE ROUBIN*, SANDRINE PIZETTE, VINCENT[.] ...
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Degradation of small leucine rich repeat proteoglycans by matrix metalloprotease 13: identification of a new biglycan cleavage site
... small leucine-rich proteoglycans (SLRPs), was found to be involved in collagen fibril formation/interaction, with some members playing a role in the OA ...
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