Leucine-rich repeat kinase 2
Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease
... Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of genetically-determined PD [21]. The opportunity to intervene with disease-modifying therapy early in the ...
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Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
... Kim 2 , Hyuna Sim 3,4 , Hyunjun Ahn 3,4 , Janghwan Kim 3,4 , Hyemyung Seo 2 , Kwang Chul Chung 5 , Bum-Joon Park 6 , Ilhong Son 1,7* and Wongi Seol 1* Abstract Background: Leucine-rich ...
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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
... Ichimura 2 , Yumin Liu 2 , Huiqing Si 1 , Huaibin Cai 3 , Joseph V Bonventre 2 and Jie Shen 1* Abstract Background: Dominantly inherited missense mutations in leucine-rich repeat ...
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Lack of Evidence for Decreased Protein Stability in the 2397 (Met) Haplotype of the Leucine Rich Repeat Kinase 2 Protein Implicated in Parkinson’s Disease
... the leucine rich repeat kinase 2 ( LRRK 2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s ...
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Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson’s disease mutant of Leucine-rich repeat kinase 2 (LRRK2)
... Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 2010, 40:503 – 517. 2. Carballo-Carbajal I, Weber-Endress S, Rovelli G, Chan ...
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The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... Mn 2+ , compared to WT LRRK2, suggests that a more rapid exchange of Mn- ATP/ADP at the active site may be partially responsible for the increased catalytic rate of G2019S LRRK2 in the presence of Mn 2+ ...
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Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
... or kinase inhibition exhibit a reduction of inflammation after lipopolysaccharide (LPS) or α-synuclein pre-formed fibrils (α-Syn pffs) ...protein kinase A (PKA) activity, triggering an increase of ...
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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
... Important clues on the a-syn/LRRK2 interplay come from a recent work by Cai and collaborators [102]. Using the tetracycline-controlled transactivator system, they generated a number of inducible transgenic mice ...
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Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
... increased kinase activity that occurs with G2019S ...increases kinase activity but should not affect non-kinase mechanisms, suggest- ing a possible selective role for kinase-mediated actions ...
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
... Immunostaining Mice were subjected to flush-perfusion with hepari- nized saline, followed by perfusion-fixation with 4 % paraformaldehyde. The brains were removed, immersed in 4 % paraformaldehyde overnight, and ...
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Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
... LRRK2 has been linked to several pathways in neuronal cells, including vesicular trafficking [9, 10], cytoskeletal dynamics [11–13], mitochondrial functions [14, 15], apoptosis [16], and autophagy process [17, 18]. ...
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Functional characterization of sequence variants in leucine-rich repeat kinase 2 (LRRK2) and its possible interaction with the translocase of outer mitochondrial membrane (TOM) protein complex
... die kinase domein en verhoog kinase aktiwiteit van ...die kinase domein van LRRK2 en vereis verdere ondersoek ten einde vas te stel of dit wel patogenies ...
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The Leucine-Rich Repeat Receptor Kinase BIR2 Is a Negative Regulator of BAK1 in Plant Immunity
... a kinase-activity-dependent manner and nega- tively controls complex formation of BAK1 with specific ligand-binding receptors—a novel regulatory mechanism for ...
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MtNRLK1, a CLAVATA1-like leucine-rich repeat receptor-like kinase upregulated during nodulation in Medicago truncatula
... Carole Laffont 1 , Carolien De Cuyper 2,3 , Justine Fromentin 2,3 , Virginie Mortier 2,3 , Annick De Keyser 2,3 , Christa Verplancke 2,3 , Marcelle Holsters 2,3 , Sofie Goormachtig 2,3 & Florian Frugier 1 Peptides are ...
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thick tassel dwarf1 encodes a putative maize ortholog of the Arabidopsis CLAVATA1 leucine rich repeat receptor like kinase
... We also compared td1 transcript levels in immature ears of normal siblings and td1-glf homozygous mutant plants by RNA gel blot experiments. As shown in Fig. 5A, a larger, aberrant transcript was detected using a ...
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Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... 97 3.2. Introduction Sexual reproduction in plants is an intricate process involving pollen pistil interaction between male and female gametophytes. Through pollen tube formation, the male gametophyte is directed towards ...
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The gene FLORAL ORGAN NUMBER1 regulates floral meristem size in rice and encodes a leucine rich repeat receptor kinase orthologous to Arabidopsis CLAVATA1
... FON1 is expressed in all types of meristem in the aerial part of rice, from the shoot apical meristem in embryos to the floral meristem. Unlike the floral meristem, however, the vegetative and inflorescence meristems ...
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Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins
... LRR-receptor kinase (LRR-RK) and LRR- receptor protein (LRR-RP) classes [3–6], in intracellu- lar nucleotide-binding site–LRR proteins (NBS–LRR) [7], in F-box proteins including hormone receptors of the E3 ...
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A Pathogen-Responsive Leucine Rich Receptor Like Kinase Contributes to Fusarium Resistance in Cereals
... To conclude, this study highlighted the contribution of specific wheat and barley leucine rich repeat receptor like kinase homologs to Fusarium resistance. These should be further investigated ...
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LRRC3B, Encoding a Leucine-Rich Repeat-Containing Protein, Is a Putative Tumor Suppressor Gene in Gastric Cancer
... To understand how LRRC3B exerts its tumor suppressive function, we performed microarray analysis with xenograft tumors derived from a stable LRRC3B-expressing cell line, as gene expression analysis of xenograft models ...
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