leukaemia cells
CD47 is Up-Regulated on Leukaemia Cells to Avoid Apoptosis In Vitro
... all cells in the body including lymphocytes (Kinashi, ...stem cells (Chao et ...phagocytic cells that express signal regulatory protein alpha, SIRPα (Chao et ...lymphocytic leukaemia ...
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The role of ceramide in growth arrest and terminal differentiation of human leukaemia cells
... In a recent study we demonstrated that ceramide caused terminal differentiation of the U937 monoblastic leukaemia cells that was characterised by cell cycle arrest and activation of the [r] ...
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Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells
... positive cells, we first used phospho- specific antibodies raised against phospho-tyrosine in gen- eral (pY), pY452 (PI3K recruitment) and the PI3K dependent feedback phosphorylation sites S159, S210 and T391 ...
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Ibrutinib induces chromatin reorganisation of chronic lymphocytic leukaemia cells
... lysine 27 acetylation (H3K27ac). The equilibrium between open and repressed chromatin is dynamic and can change transiently or permanently in response to various endo- genous or exogenous stimuli. These processes are ...
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The regulation of inositol lipid breakdown during the differentiation of HL60 myeloid leukaemia cells
... The biochemical effects of \-src induced transformation have also been investigated using mutants which encode temperature-sensitive tyrosine kinases. In chicken embryo fibroblasts, transfected with the transforming ...
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Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells
... Neoplastic cells frequently have an increased number of transferrin ...a leukaemia cell line (HL60), a multidrug-resistant leukaemia cell line (HL60ADR) and a normal tissue cell line (human ...tumour ...
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A molecular signature of dormancy in CD34+CD38 acute myeloid leukaemia cells
... lymphoblastic leukaemia; AML: acute myeloid leukaemia; Β2M: beta 2 microglobulin; BM: bone marrow; BTG2: B cell translocation gene 2; CDKN2B: cyclin-dependent kinase inhibitor 2B; CEBPA: CCAT enhancer ...
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Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
... We have shown that transcriptional RP2 inhibitors are better able than conventional agents to target dormancy-enriched AML cells. We hypothesised that a therapeutic window might exist for dormant cancer ...
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Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations
... Case 1 was an otherwise healthy 5-year-old boy with left-sided exophthalmos, a swollen lacrimal gland and a bluish-red discolouration of the eyelid. The eye examination, including visual acuity, was normal. A CT scan ...
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An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia
... males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
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Cellular mediators of anti-leukaemic activity
... candidate leukaemia specific antigen in the BCR/ABL fusion protein resulting from the t(9;22) chromosomal translocation (which is also known as the Philadelphia positive translocation), identified in cases of CML ...
259
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity
... THP-1 cells. Cells were exposed for 4 h to ligands (see below) with or without 1 h pre-treatment with 1 mM caffeine (this concentration corresponds to a therapeutic dose of caffeine and is well below the ...
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The anti cancer activity of the natural product, fucoidan, in haematological malignancies
... New insights provided by research using combined treatment of ATO and ATRA led to this chemotherapy being offered in 1998 (26). Subsequently, cell culture and animal studies revealed a significantly increased cell death ...
238
Original Article Targeting eradication of chronic myeloid leukemia using chimeric oncolytic adenovirus to drive IL-24 expression
... Different cytokines or chemokines (IL-2, IL-4, IL-6, IL-7; IL-12, GM-CSF) have been used to activate antitumoral activity. IL-24 is among the cytokines with most potent antitumoral activity. The melanoma ...
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Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? : a patient paradigm
... antigen cells ever present in the fibrovascular ...that cells of eight distinct classes (naïve and memory B cells, T cells, erythrocytes, con- nective tissue, fibrovascular network, smooth ...
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Chromosome studies in familial leukaemia and chronic lymphocytic leukaemia
... of confidence th:,t thc'Ietaphnses exam.ined are th.ose of leuk'lernic cells, 'the inoculwn :::houl,; oonsiflt lrrge ly of im;:mture forms b:asts, promyelocytes.. good mitotic activity s[r] ...
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Childhood cancer in the vicinity of the Sutro Tower, San Francisco.
... e.g. leukaemia or brain ...adult leukaemia, based on 6 leukaemia cases inside ...for Leukaemia, consistent with the combination of population and radiation ...
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Bone Marrow Microenvironment-mediated Resistance to Chemotherapy in Leukemia
... hematopoietic cells in vivo and in vitro (30, ...leukemic cells and the tumor microenvironment by targeting the SDF-1α/CXCR4 axis with SDF-1α antibodies, CXCR4-neutralizing antibodies, or the CXCR4 ...
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Cancer cell transmission via the placenta.
... enough cells and a high mutation rate, it is perhaps to be expected that cancer clone evo- lution should, at least very occasionally, enable between-host transmission? The answer to this question is yes, as it has ...
10
Becker, Susanne Isabel (2003): Leukaemia Incidence in Children and Adults in the Regions of Russia Most Highly Contaminated after the Chernobyl Nuclear Power Plant Accident. Dissertation, LMU München: Medizinische Fakultät
... acute leukaemia, there are a number of established risk factors such as ionizing radiation, certain genetic constellations like Down’s syndrome, Ataxia teleangiectasia, Fanconi’s anaemia, type I neurofibromatosis, ...
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