Leukemia stem cells
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
... Imatinib-insensitive leukemia stem cells (LSCs) are believed to be responsible for resistance to BCR-ABL tyrosine kinase inhibitors and relapse of chronic myelogenous leukemia ...
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Role of Pten in leukemia stem cells
... myeloid leukemia (CML) is initiated from the BCR-ABL-expressing leukemia stem cells ...myeloid leukemia (AML) and progenitor cells of T-ALL ...
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Heterogeneity of leukemia initiating capacity of chronic myelogenous leukemia stem cells
... heterogeneous leukemia-initiating capacity and drug sensitivity of CML LTHSCs and suggest that high MPL–expressing CML stem cells are potential targets for ...
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Chronic myeloid leukemia stem cells require cell autonomous pleiotrophin signaling
... heavy- and light-chain variable regions of an anti-PTN antibody, obtained from patent US7888485 (clone 3B10, sequence IDs 03 and 08) were synthesized (Genscript) (66). Resulting DNA was subcloned into linearized pcDNA3.4 ...
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Antineoplastic effects and mechanisms of micheliolide in acute myelogenous leukemia stem cells
... myelogenous leukemia (AML) ...leukemic cells compared to normal lymphocytes [16, ...leukemic cells to oxidative stress is considered to be a significant factor in establishing a drug resistance ...
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Molecular signatures of chronic myeloid leukemia stem cells
... β-catenin is a key factor in HSC development, and is ac- tivated by Wnt ligand binding to the receptor. Its stabil- ity after activation is highly regulated by a destruction complex involving the tumor suppressor ...
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Parthenolide Induces Apoptosis in Committed Progenitor AML Cell line U937 via Reduction in Osteopontin
... Background: Interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. Alternative treatments with herbal extracts offer insights ...
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Universal monitoring of minimal residual disease in acute myeloid leukemia
... sponding cells from 5 cord blood or bone marrow samples served as a normal ...of leukemia stem cells from 12 AML samples and 5 normal bone marrow ...in leukemia stem ...
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An RNA editing fingerprint of cancer stem cell reprogramming
... human leukemia stem cells (LSC) from patients with blast crisis (BC) chronic myeloid leukemia (CML) harbored increased expression of ADAR1 com- pared with normal and chronic phase (CP) ...
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Drugging the unfolded protein response in acute leukemias
... cancerous stem cells into non-stem cell state and vice versa, they are usually not affected by conventional and even targeted therapies ...whether leukemia stem cells are ...
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Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells
... hematopoietic stem cells was low, while it was overexpressed signifi- cantly in leukemia stem cells ...targeting leukemia stem ...eliminate leukemia stem ...
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Neural stem and progenitor cells in cancer and development
... cancer stem or stem-like cells in leukemia, breast cancer, and brain tumors, and shown that these cells can self-renew, are multipotent, and can recapitulate characteristics of the ...
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Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway
... AML cells carrying miR-4532 exert a suppressive effect on hematopoiesis of HSCs by the LDOC-dependent STAT3 signaling pathway, which facilitates a novel aspect of the treatment of AML ...
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Inhibition of IRE1 a-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
... XBP1 and its spliced form XBP1s have been reported to be upregulated in several types of cancers, and blockage of the IRE1/XBP1 pathway is considered as a promising therapeutic option [55, 57–61]. XBP1 is one of the most ...
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Arseni, Natalia (2006): Characterization of the Proteins HPIP and VENTX2 as Novel Regulatory Proteins of Human Hematopoiesis. Dissertation, LMU München: Medizinische Fakultät
... hematopoietic stem cell was first demonstrated in mice 5 . Mouse bone marrow cells injected into lethally irradiated syngenic mice were capable of forming discrete nodules in the spleens of the recipients 7 ...
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Is alkaline phosphatase the smoking gun for highly refractory primitive leukemic cells?
... (ALP) stem cell detection method based on the identification of alkaline phosphatase fluorescent cells in combination with flow cytometry ...with leukemia and lymphoma, showing that changes in the ...
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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
... Moreover, the signal integration of non-canonical GLI1/2 activation by PI3K/AKT was also deciphered as a novel potential therapeutic target because combination of the GLI inhibitor GANT61 and the AKT inhibitor perifosine ...
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Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases
... into cells, these 8-base were integrated into the exon1 of bcr-abl sequence by HDR and generated a stop codon in the downstream of ZFNs cleavage site, ultim- ately leading to premature termination of BCR-ABL ...
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Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation
... blood stem cells will acquire donor-derived passive immunity, whereas cord blood stem cells are immunological naïve, and upon activa- tion, donor-derived T cells will aim at CMV lesion ...
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A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation
... lations such as HSPCs and pre-B cells possess the engraft- ment capacity in immunodeficient mice [12,13]. Given that LSCs of CML are resistant to TKIs due to their quies- cence and independent maintenance from ...
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