Leukemic cells
Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML patients, the HPC from their remission bone marrow (remission-HPC), and normal HPC from their HLA-identical sibling bone ...
8
Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... lymphoblastic leukemic cells in mice [15]. However, its expression in AML cells has not been studied in ...that leukemic cells highly express GDF15, ...
10
Cytotoxicity of Metoprolol on Leukemic Cells in Vitro
... In this study, we used the software SPSS 24 package (SPSS Inc, Chicago, IL) for data analysis and statistical calculation. The effect of metoprolol on viability of leukemic cells was assessed in 5 ...
6
Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro
... in cells from one patient. These cells also expressed an Epo receptor (1,000 receptors per cell) with a 420-pM affinity and Epo was detected in the supernatant of cultured ...cases, leukemic ...
10
Fluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell Line
... Evidence suggests that CSCs are integral to the development of several forms of human cancer. Effort now focused on identifying and isolating CSCs. Cell-sorting technologies based on the CSCs markers or Hoechst dye ...
9
A role for dystroglycan in the pathophysiology of acute leukemic cells.
... The physiological role of Dg is to establish communication between cells and their microenvironment, making connections with the extracellular matrix proteins and cytoskeletal elements. The following three ...
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Further observations on the folate binding factor in some leukemic cells
... myelogenous leukemia, contained a macromolecular factor which bound tritiated folic acid. Bound tracer folate filtered through Sephadex G-75 and G-100 columns with the early effluent and appeared with the inner volume ...
9
Effect of67 Zn-Nanoparticles on Leukemic Cells and Normal Lymphocytes
... Mononuclear Cells from Bone Marrow and Periferic Blood All manipulations were made under sterile conditions in a chamber with laminar flow of air (Flow ...blood cells were diluted by standard medium RPMI ...
10
Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti Tac Monoclonal antibody identifying the human receptor for T cell growth factor
... virus. Leukemic cells of both groups were of the T3, T4-positive, T8-negative ...Sézary leukemic cells frequently functioned as helper cells, whereas some HTLV-positive ATL and ...
9
Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche
... REH cells in the same conditions (not shown). In this latter niche, REH cells were very difficult to be detached from the MSC and therefore accurately molecular evaluation of HSC after co-incubation was ...
11
PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH) AND 11-DEHYDRO-17 HYDROXY CORTICOSTERONE (CORTISONE) THERAPY IN THE LEUKEMIAS AND LYMPHOMAS OF CHILDREN
... marrow was not as clear as that between uric acid excretion and the destruction of periph- eral- leukemic cells, these two effects do appear to be related.. The marrow blast cells.[r] ...
14
WDR5 high expression and its effect on tumorigenesis in leukemia
... in leukemic cells [31,32], however it has no report about global correlation of WDR5 binding with H3K4me3 binding ...the cells, we identified the H3K4me3 binding profiling in RS4;11 and THP-1 ...
15
CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies
... dendritic cells, associated with a transient decrease of NK lymphocytes and with virtually no effects at the level of monocytes and pluripotent bone marrow progenitor/stem cells ...AML cells ...
11
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A Siwei Zhang 1, Lina S. Schneider1 , Binje Vick 2,4 , Michaela Grunert 2, Irmela Jeremias 2,3,4 , Dirk Menche 5, Rolf Müller6 , Angelika M. Vollmar 1and Johanna Liebl1
... in leukemic cells ...fact, cells without Archazolid A treatment pass S-phase (8h) to reach (16h) and accumulate (20h, 24h) in ...treated cells accumulate in S-phase (8h, 16h, 20h) but do not ...
21
Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
... primary leukemic samples from adult ALL patients and, in particular, in the relapsed samples, confirming previous data in solid tumors from multiple studies [24, 27, ...primary leukemic cells, the ...
18
Senescent stromal cell-induced divergence and therapeutic resistance in T cell acute lymphoblastic leukemia/lymphoma
... (CEM) cells, we show that CEM cells induce pulmonary remodeling in immunocompromised mice, suggesting potential interaction between these cells and lung ...CEM cells leading to diminished ...
16
Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients
... B cells and measure of the average number of B-cell divisions in CLL patients While the decreased Ig synthesis in CLL has been pre- viously ascribed to the release of inhibitory cytokines upon cell-cell contact ...
7
Telomeric DNA in normal and leukemic blood cells
... blood cells obtained from donors in their twenties to sixties, and the telomere length ranged between ...The leukemic cells of 12 patients with acute leukemia (seven with myeloid and five with ...
8
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
... epithelial cells in the adult. We have found that CDX2 is expressed in leukemic cells of 90% of patients with acute myeloid leukemia (AML) but not in hematopoietic stem and progenitor cells ...
13
Ebinger, Sarah (2018): Characterization of dormant and drug resistant stem cells using xenograft mouse models of patient-derived acute leukemia cells. Dissertation, LMU München: Fakultät für Biologie
... PDX cells at early time points and low cell ...malignant cells (De Kouchkovsky and Abdul-Hay, ...of leukemic cells can easily be isolated and ...early leukemic development (Barrett et ...
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