Leukocyte adhesion
Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu CAM) deficiency
... The leukocyte adhesion molecules CD11a/CD18, CD11b/CD18, and CD11c/CD18 (Leu- CAM) are members of the integrin receptor family and mediate crucial adhesion-dependent functions in ...
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Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions
... of leukocyte adhesion/transmigration on the level of a single cross section has previously not been ...of leukocyte adhesion along the length of the stented segment soon after vascular ...
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Endothelial leukocyte adhesion molecule 1 mediates antigen induced acute airway inflammation and late phase airway obstruction in monkeys
... endothelial leukocyte adhesion molecule-1 (ELAM-1) in the development of the acute airway inflammation (cell influx) and late-phase airway obstruction in a primate model of extrinsic ...
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The Biophysics Of Leukocyte Adhesion Deficiency
... The leukocyte adhesion cascade has evolved to slow and stop cells to allow this ...of leukocyte adhesion can be maintained using varying ratios of the two ...cellular adhesion. We ...
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Golgi nucleotide sugar transport and leukocyte adhesion deficiency II
... new adhesion deficiency syndrome was described in two unrelated Arab boys, then 3 and 5 years old, each the offspring of a consanguineous mating (1, ...described leukocyte adhesion deficiency (LADI, ...
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Allogeneic Hematopoietic Stem-Cell Transplantation for Leukocyte Adhesion Deficiency
... OBJECTIVES. Leukocyte adhesion deficiency is a rare primary immune disorder caused by defects of the CD18  -integrin molecule on immune cells. The condition usually presents in early infancy and is ...
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Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM
... Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion ...
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Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2
... classic leukocyte adhesion deficiency syndrome, now designated type 1 (LAD I), but the two syndromes differ in the molecular basis of their adhesion ...integrin adhesion molecules while LAD II ...
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A role for S100 proteins, MRP-8 and MRP-14 in leukocyte adhesion
... However, all of the above experiments were performed in vitro and their validity as modulators of integrin function in vivo remains to be determined. One of the criteria for integrin activation in vivo would be that the ...
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Post-translational modification-regulated leukocyte adhesion and migration
... the leukocyte, termed the uropod, detaches itself from the underlying substratum and undergoes retraction to facilitate forward movement of the ...of adhesion structures ...mediating leukocyte ...
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An in vivo animal model of gene therapy for leukocyte adhesion deficiency
... Table L Cell Surface Expression ofHuman CD18 and Various Murine Epitopes on Nucleated Cells from the Tissues ofMouse 15-6, Six Months after Bone Marrow Transplantation Blood.. Cells were[r] ...
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Rheostat regulation of integrin mediated leukocyte adhesion
... on HEVs with high affinity, leading to the firm adhesion of rolling lymphocytes. The T cells then transmigrate across the endothelium into the T cell zone of the secondary lymphoid organs, where dendritic cells ...
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Requirements for leukocyte adhesion molecules in nephrotoxic nephritis
... molecule-1, and vascular adhesion molecule-1. Treatment of rats with anti-TNF alpha or soluble recombinant human TNF receptor-1 blocked this expression. Renal arterial infusion of TNF alpha induced glomerular ...
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The tripeptide feG inhibits leukocyte adhesion
... The protocols for all animal experiments were approved by the University of Calgary Health Sciences Animal Care Committee, which conforms to the guidelines of the Canadian Council on Animal Care. Male Sprague-Dawley rats ...
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Sickle cell disease: old discoveries, new concepts, and future promise
... Intravenous gammaglobulins are currently under clinical evaluation following a study demonstrating a dosedependent reduction in leukocyte adhesion and in the number of interactions betwe[r] ...
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Selectins
... Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-I and vascular cell adhesion molecule-l.. Four [r] ...
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Biomechanical activation: an emerging paradigm in endothelial adhesion biology
... other adhesion molecules such as intercel- lular adhesion molecule-1 (ICAM-1), as well as chemoattrac- tant cytokines such as IL-8 and monocyte chemoattractant protein-1 (MCP-1), involved in ...
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Leukocyte endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF kB dependent fashion
... Experimental evidence is available that expression of adhe- sive molecules is critically dependent by intracytoplasmic acti- vation of NF-kB. Thus specific subunits of NF-kB differen- tially regulate gene expression of ...
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The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
... Our findings add to the existing literature in impor- tant ways. First, with the exception of a study in which PAI-1 levels were measured in 840 patients with severe sepsis enrolled in the PROWESS trial [36], the current ...
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Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF α treated SGBS Human Adipocytes
... endothelial adhesion molecules, in- cluding vascular cell adhesion molecule-1, endo- thelial-leukocyte adhesion molecule-1, and intra- cellular adhesion molecule-1, plays a pivotal role ...
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