Leukotriene B4 receptor 2
Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
... Moreover, we found that BLT2 is expressed in pul- monary epithelial type II cells and vascular endothelial cells in the mouse lung. To investigate the roles of BLT2 in lungs, mice were intratracheally treated with ...
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Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells
... Lipopolysaccharide (LPS) is a key component of the outer membrane of Gram-negative bacteria and is specifically recognized by Toll-like receptor 4 (TLR4) [1, 2]. Recent studies have demonstrated that TLR4 ...
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Characterisation of the binding of leukotriene B4 to macrophages of the rainbow trout Oncorhynchus mykiss
... of receptor occupancy by the radiolabel (Hulme and Birdsall, 1992), thereby identifying the quantity of radioactivity that had partitioned into the membrane or other hydrophobic areas, had become entrapped in the ...
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Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin triggered lipoxins in reperfusion
... for 2 minutes) using primer sets (a) specific for hBLTR: BLTR-N and BLTR-C, which amplify the entire coding region of hBLTR; or (b) CD11b5′ (5′-GGCACCTTTTGGATAGTGGTATTG-3′) and Figure ...
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Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis
... the 2-APB inhibitor requires caution as it has been shown to block both store operated calcium entry (SOCE) as well as inositol triphosphate? gated channels within calcium stores ...study, 2-APB has been ...
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Leukotriene B4 Receptor (BLT-1) Modulates Neutrophil Influx into the Peritoneum but Not the Lung and Liver during Surgically Induced Bacterial Peritonitis in Mice
... was similar to that in the WT mice, indicating a true defect in ligand-receptor interaction. Interestingly, the survival benefit was associated with increased bacterial levels early on after CLP, which likely ...
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Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children
... Four groups of children were studied: 15 healthy children, 20 atopic nonasthmatic children, 25 steroid-naïve atopic asthmatic children, and 22 atopic asthmatic children who were receiving inhaled corticosteroids (Table ...
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Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats
... × 2-N-morpholino- ethane sulfonic acid (MES)-SDS running buffer (Invitro- ...for 2 h at room tempera- ...for 2 h, immunoreactiv- ity was visualized with chemiluminescence using an Image Station ...
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Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
... Mannose receptor (MR, CD206), mac- rophage galactose N-acetyl-glactosamine specific lectin, (Mgl, CD301), programmed cell death 1 ligand 2 (PD-L2, CD273), and PD-L1 (CD274) are well characterized as the ...
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Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice
... toxin receptor (MMDTR) ...At 2 days after infection, while diabetic MMDTR mice had a significantly larger infection area compared with nondiabetic MMDTR mice, DT-treated dia- betic MMDTR mice exhibited a ...
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Leukotriene B4 receptor locus gene characterisation and association studies in asthma
... There was ubiquitous expression of LTB4R1 and LTB4R2 mRNA in the airway and periphery cells, including lung, HASM, HBEC, PBMC, PMN, BEAS-2B and THP-1 (data not shown). 5 0 RACE data for LTB4R1 and LTB4R2 was generated ...
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Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
... The mouse fibroblastic 3T3-L1 cell line established by Green is widely used for the investigation of adipocyte differentiation [13,15,16]. The involvement of various molecules for adipocyte differentiation has been ...
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Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases
... Gene enrichment analysis of these s-DMR regions was performed using the Genomic Regions Enrichment of Annotations Tool (GREAT) [74]. A large number of sig- nificant biological, human phenotype and disease-related ...
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The Comparison of the Levels of Leukotriene B4, TGF β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast
... of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the inflammation phase and tissue proliferation has not been clearly ...fibroblast. Leukotriene B4 (LTB4) is one of the ...
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PU 1 is involved in the immune response to Aspergillus fumigatus through upregulating Dectin 1 expression
... A. fumigatus A1 was kindly provided by the Microbio- logical Laboratory of Jinling Hospital. After culture on Sabouraud dextrose agar plates for 7 days at 28 °C, co- nidia were harvested by washing the plates with ...
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Dual inhibition of complement factor 5 and leukotriene B4 synergistically suppresses murine pemphigoid disease
... of the plates on a 3-μm polycarbonate membrane (Costar Nucleopore GmbH). For chemokinesis con- trol, LTB 4 or C5a was added to the neutrophils on top of the membrane instead of to the bottom wells. The plate was ...
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A comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma
... Asthma is one of the most prevalent chronic diseases in childhood [1], yet diagnosing and treating asthma in children remains challenging. Poor control of asthma in children and adolescents is common and represents a ...
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Prostaglandin E2/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection
... donovani dissemination and impairment of NOS2 was demonstrated [34,35]. The inoculation of L. longipalpis SGS plus L. infantum increased parasite viability inside peritoneal cells. The pharmacological inhibition of ...
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Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor
... CysLT 2 (1:50, 1:50, 1:250, and 1:250, respec- ...CysLT 2 were analyzed in the presence or absence of appropriate specific receptor blocking peptides (both from Cayman Chemical, at 1:1 ratio to the ...
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Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report I.H. Yoon, H.J. Han, J.H. Kim*
... in the overall lung field and a cardiac size within the normal range (vertebral heart score, 10.2; reference range 8.5–10.5) (Figures 1A and 1B). To exclude other potential causes of coughing, the dog underwent com- ...
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