Lewy body
Original Article Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease
... In Lewy body disease, Lewy pathology (LP: the accumulation of α-synuclein in neuronal perikarya and pro- cesses as Lewy bodies and Lewy neurites and dots, respectively) is observed in ...
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Dysphagia in Lewy body dementia - a clinical observational study of swallowing function by videofluoroscopic examination
... Despite the use of quite unspecific screening questions of dysphagia in the present study, all but two patients who confirmed at least one of the questions had objective swallowing dysfunction on VFSE. The high ...
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An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias
... and Lewy neurites, is the focus of several genetic and biomarker studies in Lewy body dementias that failed to provide any consistent trend ...the Lewy body dementias group (Additional ...
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Compensatory shifts in visual perception are associated with hallucinations in Lewy body disorders
... of Lewy body and other ...in Lewy body disease, have similar content to spontaneous hallucinations, and respond to cholinesterase inhibitors in the same ...with Lewy body ...
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TIGAR inclusion pathology is specific for Lewy body diseases
... the Lewy body, primarily located in the substantia nigra, but also found in other brainstem and forebrain ...nigra Lewy bodies are usually round with a hyaline, eosinophilic core with a paler ...
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Interleukin-1 mediates Alzheimer and Lewy body pathologies
... perhaps indicative of inflammation-related synapse loss, and (ii) an increase in α-synuclein, perhaps in an attempt to repair this very event [34]. The effect of IL-1β on α- synuclein in cultures of primary neurons is ...
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Alpha-synuclein biology in Lewy body diseases
... Lewy body pathology in Alzheimer ’ s disease Although Lewy bodies are the pathological hallmark of PD and DLB, recent studies suggest a considerable pro- portion of AD brains show α-synuclein ...
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Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders
... contribute to the development of cognitive impairments in both Alzheimer ’ s disease (AD) and Lewy body disorders (LBD). It has been reported that, in late stage AD, a network of fibres that contain the ...
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Tyrosine hydroxylase and Lewy body molecules immunoreactivity in the SNC neurons of an AS/AGU mutantrat
... the Lewy body as- sociated proteins ubiquitin and parkin in the nigral cell bodies of the mutant and to compare them with control (unaffected) animals, individual cells of the two ...
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Intra neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
... of Lewy bodies — cytoplasmic inclusions containing α-synuclein protein aggregates — in the affected ...of Lewy body diseases is loss of sympathetic nerves in the heart and other organs, manifesting ...
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Characteristics of facial expression recognition ability in patients with Lewy body disease
... with Lewy body disease, the aim of this study is to examine points to facilitate smooth communication between caregivers and patients with the disease whose cognitive function has ...with Lewy ...
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MRI of the Swallow Tail Sign: A Useful Marker in the Diagnosis of Lewy Body Dementia?
... MATERIALS AND METHODS: This was a retrospective cross-sectional multicenter study including 97 patients (mean age, 65 ⫾ 10 years; 46% women), consisting of the following: controls (n ⫽ 21) and those with Lewy ...
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A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
... with Lewy body disease, and compared its levels with re- gard to the presence of dementia ...(i.e., Lewy body demen- tia, LBD) or the absence of dementia ...
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Lewy body dementia: the impact on patients and caregivers
... The Lewy body dementias (LBDs) are the second most common form of dementia in older adults after Alzhei- mer ’ s disease (AD) ...with Lewy bodies (DLB), with the difference being one of timing of ...
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Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias
... the Lewy Body Dementia Association (LBDA) reflect its corporate tagline, ‘ Increasing Knowledge, Sharing Experience, Building Hope ’ and provide outreach to families, increase awareness in the public and ...
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Computational modeling reveals multiple abnormalities of myocardial noradrenergic function in Lewy body diseases
... with Lewy body diseases (7 PAF, 6 PD with orthostatic hypotension, 64 ± 4 years, 9 men) (28, 38) and (b) post- mortem studies of apical myocardial catechols in 23 control subjects and 8 patients with ...
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Lewy Body Dementia (Update)
... Lewy body dementia refers to either of two related diagnoses—dementia with Lewy bodies and Parkinson’s disease ...with Lewy bodies, cognitive symptoms develop within a year of parkinsonism—any ...
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Biomarkers for the diagnosis of Alzheimer’s disease, dementia Lewy body, frontotemporal dementia and vascular dementia
... discovery of most known biomarkers specific to dementia. The vast majority of biomarkers are only obtained through lumbar punctures. The results that come from these methods are heavily dependent on the age and phys- ...
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Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?
... Background: The NIA-AA research framework proposes a biological definition of Alzheimer ’ s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms. ...
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Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
... and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia ...the Lewy body, the mechanisms by which neurons ...
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