LFA-1
LFA-1 Expression on Target Cells Promotes Human Immunodeficiency Virus Type 1 Infection and Transmission
... avid LFA-1 on the cell surface is not sufficient; rather, properly functional LFA-1 that can regulate its adhesiveness is ...active LFA-1 deletion mutant on target cells did not ...
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Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes
... of LFA-1 consists of an amino termi- nal-inserted-domain (I-domain, approximately 200 amino acids), which is necessary for LFA-1 binding to ...
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A novel leukocyte adhesion deficiency caused by expressed but nonfunctional β2 integrins Mac 1 and LFA 1
... and LFA-1 on T cells failed to bind ligands such as fibrinogen and intercellular adhesion molecule (ICAM)-1, respectively, or to display a b2-integrin activation epitope after adhesion-inducing ...
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Rapid Flow Cytometry Method for Quantitation of LFA-1-Adhesive T Cells
... although LFA-1 is thought to be the most likely binding receptor on T cells, it cannot be excluded that other cell surface integrin molecules may also contribute to the T-cell binding of the ICAM-1 ...
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Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.
... It has been our hypothesis for some time that adhesion molecules on virus-susceptible cells and the virus particles themselves play an important role in virus infection (13, 18, 27). On the basis of the work presented in ...
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Analysis of dynamic tyrosine phosphoproteome in LFA 1 triggered migrating T cells
... 5. Metabolic enzymes. A large number of proteins involved in energy metabolism including mitochondrial enzymes undergoing tyrosine phosphorylation were identified in migrating T-cells (Fig. 6). Although this study did ...
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LFA 1–specific therapy prolongs allograft survival in rhesus macaques
... the LFA-1–specific mAb efalizumab has been used for the treatment of plaque psoriasis ...and 1 possible case of PML out of approximately 46,000 treated patients (37), all occurring in subjects ...
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Deficiency of a leukocyte surface glycoprotein (LFA 1) in two patients with Mo1 deficiency Effects of cell activation on Mo1/LFA 1 surface expression in normal and deficient leukocytes
... (approximately 5% of normal) but detectable amounts of the heterodimeric LFA-1 antigen were found on mitogen and alloantigen-activated T cells. On granulocytes, Mo1 surface expression was also dependent on ...
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LFA 1 is sufficient in mediating neutrophil emigration in Mac 1 deficient mice
... and LFA-1 by neutrophils may be revealed in the fol- lowing ...on LFA-1 (an integrin that appears not to signal the massive release of reactive oxygen [22]) and oc- curs rapidly, then the ...
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Strain-Specific Differences in LFA-1 Induction on Measles Virus-Infected Monocytes and Adhesion and Viral Transmission to Endothelial Cells
... in LFA-1 induction among MV strains were of biological significance, particularly with regard to enhanced ...duce LFA-1 did not correlate with enhanced monocyte adhe- sion or viral ...
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LFA-1 Is a Key Determinant for Preferential Infection of Memory CD4+ T Cells by Human Immunodeficiency Virus Type 1
... surface LFA-1 play a dominant role in the initial steps of HIV-1 life cycle once infection is allowed to proceed in PHA/ IL-2-activated CD4 ⫹ T lymphocytes (9, 21, ...
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Cooperative interactions of LFA 1 and Mac 1 with intercellular adhesion molecule 1 in facilitating adherence and transendothelial migration of human neutrophils in vitro
... exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophils to ICAM-1 by a Mac-1-dependent ...
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Ostermann, Georg (2002): Identification of junctional adhesion molecule (JAM)-1 as a novel immunoglobulin superfamily ligand for lymphocyte function-associated antigen (LFA)-1. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... activated LFA-1 but not on the presence of leukocytic JAM-1 ...specific LFA-1 mAbs decreased their arrest on CHO-JAM cells to such an extent that a contribution of trans-homophilic ...
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Dendritic cell mediated HIV 1 transmission to T cells of LAD 1 patients is impaired due to the defect in LFA 1
... Although LFA-1 of this patient is able to recognize its ligand, no high avidity/ affinity binding to ICAM-1 is taking ...through LFA-1 into the T cell (outside-in signaling) is probably ...
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Adherence of neutrophils to cultured human microvascular endothelial cells Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac 1, LFA 1, p150,95 glycoprotein family
... Mac-1, LFA-1, p150,95 glycoprotein family on the neutrophil surface since neutrophils from patients with leukocyte adhesion deficiency, lacking surface expression of the adhesive glycoproteins, ...
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Suppressed expression of ICAM 1 and LFA 1 and abrogation of leukocyte collaboration after exposure of human mononuclear leukocytes to respiratory syncytial virus in vitro Comparison with exposure to influenza virus
... clustering. In contrast, exposure to RSV was associated with suppressed expression of both ICAM-1 and LFA-1 and with minimal detectable cell clustering throughout the culture period. Influenza ...
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Adhesion activating phorbol ester increases the mobility of leukocyte integrin LFA 1 in cultured lymphocytes
... lowed to settle onto cells. The binding of these beads was specific: while IB4 beads began to bind to cells within a few minutes, beads coated with an irrelevant antibody did not bind, even after . 1 h. Moreover, ...
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Role of LFA-1 and ICAM-1 in Cancer
... helper 1 are deficient in CLL ...impaired LFA-1 clustering at the immune synapse ...defective LFA-1-mediated migration, due to dysregulated Rho GTPase signaling ...rescued ...
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LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse
... by LFA-1 signaling into the infected cell through a ZAP70-dependent ...lamp 1 (green) (B), the early endosome marker EEA-1 (green) (C), or the recycling endosome marker Rab11a (green) ...lamp ...
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T Cells Expressing Activated LFA-1 Are More Susceptible to Infection with Human Immunodeficiency Virus Type 1 Particles Bearing Host-Encoded ICAM-1
... type 1 (HIV-1) par- ticles is a well-established ...of LFA-1 to high affinity for ICAM-1 with the use of anti-LFA-1 antibodies (clones NKI-L16 and MEM83) markedly enhances ...
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