LIGAND-BINDING DOMAIN
A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis
... protein, binding to DR-1 rec- ognition sites on genomic ...C-terminal ligand-binding domain with a hydrophobic pocket, terminated by an ␣ -helix, termed an AF-2 domain, which serves as ...
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Functional Characterization of Two Mutations Located in the Ligand Binding Domain in the SF1
... DNA-binding domain (DBD) containing two zinc fingers, a hinge region containing a first functional activation domain (AF-1), a ligand-binding domain (LBD) of 12 helices (H1-H12) ...
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Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2
... its ligand-binding site and sub- divide it into multiple ...the ligand-binding domain of ...TNF ligand binding to the ...the ligand-binding region of TNFR2 ...
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Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain
... for ligand-induced MET activation but also exhibited a degree of agonism when tested in the absence of added ...natural ligand, was observed with peak agonistic activity around 1 nM 7A2 scFv and a maximum ...
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Rational ligand based drug design and structure activity relationship studies in the ligand binding domain of the glucocorticoid receptor ?
... the binding pocket coming from x-rays while focusing on the key features involved in the ligand–protein ...upon ligand binding, as in the case of the other NRs, which often leads to unpredict- ...
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Mutations in the ligand binding domain of the androgen receptor gene cluster in two regions of the gene
... We have analyzed the nucleotide sequence of the androgen receptor from 22 unrelated subjects with substitution mutations of the hormone-binding domain. Eleven had the phenotype of complete testicular ...
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Study protein-protein interaction in methyl-directed DNA mismatch repair in E. coli : exonuclease I (Exo I) and DNA helicas II (UvrD); A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3’-5’ exonuclease and 5’-protruding strand endonuclease activities; Solving the structure of the ligand-binding domain of the pregnane-xenobiotic-receptor with 17[beta] estradiol and T1317
... of ligand-regulated transcription factors and, like most NRs, contains both DNA- and ligand-binding domains (DBD, LBD, respectively) connected by a presumably flexible hinge ...bound ligand ...
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The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN
... PilJ domain of the PA2788/ McpN ...McpN ligand binding domain (LBD) at ...the ligand binding mode differs since a single nitrate molecule is bound to a site on the dimer symme- ...
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Myasthenic syndrome AChRα C loop mutant disrupts initiation of channel gating
... chimeric ligand-binding domain with bound agonist, an Arg residue at the position equivalent to αVal188 establishes close register with the residue equivalent to αTyr190 through a π-cation ...
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Rational design of a novel AMPA receptor modulator through a hybridization approach
... receptor ligand binding domain enabled the development of a new class of AMPA receptor positive allosteric modulators (7) through hybridization of known ligands (5 and 6), leading to a novel ...
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IN SILICO BASED VIRTUAL SCREENING FOR BIOACTIVE PART AGONISTSVinod Varmaan, Yuawa Rani and VasudevaRao Avupati*DOWNLOAD/VIEW/http://doi.org/10.5281/zenodo.166359
... natural ligand of this receptor is still unknown; this may be the reason for their lethal side ...PPPAγ ligand binding domain agonistic activity equal to ...
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EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH
... A shift in the position of the residues and difference in dihedral angles is noted between the proteins bearing glycine and arginine at position 16 respectively. The difference in the amino acid pattern as observed in ...
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Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human α4β2 Nicotinic Acetylcholine Receptor
... extracellular ligand-binding domain sequences of the human α4and β2 nAChR subunits were downloaded from UniProt database [26] (α4: P43681(29-242), ACHA4_HUMAN and β2: P17787(26-233), ...The ...
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Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions.
... While ligand- mediated induction of receptor dimerization is thought to be critical for full-length EGFR activation, the potential for this receptor to activate signals in a monomeric state has remained ...
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Determination of the role for CD21 during Epstein-Barr virus infection of B-lymphoblastoid cells.
... Our results demonstrate first, that two discontinuous amino acid substitutions within the ligand-binding domain of murine CR2 render it capable of mediating EBV infection of human B-lymp[r] ...
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Search | Preprints
... extracellular ligand-binding domain and an intracellular kinase domain separated by a single transmembrane ...by ligand-induced dimerization of the receptor monomer, which brings ...
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Toxicological analysis on EGFR Protein Inhibitors (Clerodane and Iressa 2) using TOPKAT analysis
... extracellular ligand-binding domain, a helical transmembrane domain, and an intracellular tyrosine kinase ...extracellular domain is the first step in a series of complex signaling ...
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Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions
... the ligand-binding domain (LBD) of the AR, neither the genital skin fibroblasts of the subjects nor trans- fected cell types expressing the mutant receptor had any androgen-binding ...reduced ...
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Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro
... the ligand binding domain of all three receptors, implying that the enzymatic generation of oleic acid from ODA is not a simple explanation for the observed ...
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A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
... To directly test this potential in human biology in vivo, we investigated the possibility that FcgRIIIa 176F/V alleles might be abnormally represented in patients with SLE, a prototypic immune complex disease. A role for ...
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