LIM domain only protein 2
Pasalic, Zlatana (2008): The four and a half LIM domain protein 2 (FHL2) interacts with CALM and is highly expressed in acute myeloid leukemia (AML) with complex aberrant karyotypes. Dissertation, LMU München: Medizinische Fakultät
... To isolate larger amount of plasmid DNA for cloning, Midi preparation was done. A bacterial colony or 20 μl of a glycerol stock was inoculated in 25 ml of LB medium containing appropriate selective antibiotics and grown ...
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Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice
... Figure 4 Transdifferentiation of isolated HSC to MFB. HSC from wt and FHL2 deficient mice were isolated by FACS-based protocols and plated on plastic surfaces for 2 or 7 days. For generation of fully ...
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The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression
... the LIM-domain only (LMO) protein family that act as mo- lecular adaptors, providing a scaffold for multiprotein complexes of DNA-binding factors and transcriptional regulatory proteins ...
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EhLimA, a Novel LIM Protein, Localizes to the Plasma Membrane in Entamoeba histolytica
... sponding protein was termed EhLimA (NCBI accession ...a protein of 145 amino acids with a calculated molecular mass of 16 ...single LIM domain at its N terminus spanning amino acid residues 6 ...
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<p>RING Finger Protein 38 Mediates LIM Domain Binding 1 Degradation and Regulates Cell Growth in Colorectal Cancer</p>
... Figure 2 RNF38 destabilizes LDB1 protein via proteasomal pathway in colorectal cancer cells. (A). Four colorectal cancer cell lines and one human normal intestinal epithelial cell line were prepared for ...
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β Cells led astray by transcription factors and the company they keep
... highest protein secretion burdens in the body, as these cells must synthesize and secrete insulin in proportion to postprandial rises in blood ...homeobox 2 (NKX2.2), paired box 6 (PAX6), and LIM ...
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An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein
... for LASP1 mediated cancer aggressiveness as silencing of LASP1 in ECA109 and KYSE510 ESCC cell lines significantly inhibited cell proliferation, migration and invasion in vitro [74]. For gastric cancer, the same has been ...
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LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells
... identity. LIM domain–binding protein 1 (LDB1) nucleates multimeric transcriptional complexes and establishes promoter-enhancer looping, thereby directing fate assignment and maturation of progenitor ...
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The cloning and characterisation of link1: A LIM-domain containing protein kinase
... the LIM-only class of proteins, in particular the nuclear proteins RBTN- 1/Ttg-1 (M cGuire et ...and 2 to induce T-cell acute lymphoblastic lymphoma in transgenic mice (Fisch et ...and 2 were ...
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Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
... VEEV TC83-Luc was kindly provided by Slobodan Paessler of the University of Texas Medical Branch at Galveston, Galveston, TX. RVFV MP12-luc was kindly provided by Shinji Makino of the University of Texas Medical Branch ...
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The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function
... Muscle LIM protein (MLP) is a cytoskeletal protein located at the Z-disc of sarcomeres. Mutations in the human MLP gene are associated with hypertrophic and dilated cardiomyopathy. MLP has been ...
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Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
... transmembrane domain of SN-HN were replaced by PI3-HN sequences showed very low activity ...membrane domain (amino acid positions 54 to 58 of PI3-HN), which would alter the location of the SN-specific amino ...
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Interaction of Poliovirus with Its Purified Receptor and Conformational Alteration in the Virion
... internal protein VP4 and is not an infectious particle ...date, only preliminary ex- periments involving a purified recombinant fusion protein, which carries the extracellular domain of hPVR ...
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The LIM homeodomain protein Lim 1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development
... IIIt I DeY llinl 40 453 461 (1996) 453 Original Artide The LlM homeodomain protein Lim 1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development ALEX A KARAVANOV[.] ...
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Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
... Tumor-free lung tissue obtained from lobectomy or pneumectomy specimens, with a minimum distance to the tumor of 10 cm, of 19 lung cancer patients, was fixed using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic ...
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The Dysferlin Domain-Only Protein, Spo73, Is Required for Prospore Membrane Extension in Saccharomyces cerevisiae
... dysferlin domain of myoferlin (Protein Data Bank [PDB] code 2K2O A chain) (30) ...dysferlin domain of dysferlin (PDB code 4CAH B chain; data not shown) ...as protein surfaces or ...
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The role of SH3BP2 in the pathophysiology of cherubism
... penetrance (70 - 50%) in females has been reported [4]. However, the authors concede in this retrospective study that only 50% of the adult female family members which were considered unaffected underwent ...
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Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins
... The discovery that AGO2 activity is regulated by phosphoryla- tion, and indeed other post-translational modifications, raises the question as to whether all four human AGO proteins are sub- ject to regulation by ...
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Enzyme activity by design : an artificial rhodium hydroformylase for linear aldehydes
... traditional Rh/TPPTS system in the biphasic hydroformyla- tion of 1-octene and 1-decene. This demonstrates that a protein chosen for its specific binding properties can be converted into an enzyme in which these ...
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The conserved LIM domain containing focal adhesion protein ZYX 1 regulates synapse maintenance in Caenorhabditis elegans
... one protein implicated in regulating cellular responses to mechanical and stress forces applied to sites of ...zinc-finger LIM domains at the C-terminus (Sadler et ...the LIM domains interact with a ...
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