Limb ischemia
Characteristics of responders to autologous bone marrow cell therapy for no-option critical limb ischemia
... Cell therapy is emerging as an alternative strategy for the treatment of patients with critical limb ischemia (CLI) who are not eligible for endovascular or surgical revascularization. Several preclinical ...
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Acute Limb Ischemia due to a Fractured Superficial Femoral Artery Stent
... A 71-year-old Caucasian male with significant peripheral arterial disease underwent stenting of the right SFA for critical limb ischemia at another facility. Patient was evaluated for surgical intervention ...
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Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia
... Background: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration ...
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Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia
... critical limb ischemia (CLI), which is characterized by rest pain and unhealing wounds of the limbs, is associ- ated with a 1-year major amputation rate of 30% and mortality rate of 25% [1, ...
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Growing blood vessels to treat limb ischemia : studie in mice and man
... of limb musculature, does not correlate well with ankle brachial pressure index, a parameter of ...during ischemia or ...with limb ischemia showed a fiber- type switch in ischemic skeletal ...
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<p>The burden of critical limb ischemia: a review of recent literature</p>
... critical limb ischemia (CLI), are recurring lower extremity rest pain, ulceration, and gangrene as well as an increased risk of cardiovascular events, amputation, and ...and limb salvage as well as ...
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Critical limb ischemia in a patient with systemic lupus erythematosus: a case report
... Critical limb ischemia; CRP: C-reactive protein; CT: Computed tomography; CVD: Cerebrovascular disease; DS- DNA: Double-stranded DNA; EVT: Endovascular therapy; OPD: Out-patient department; PAD: Peripheral ...
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Imaging receptor for advanced glycation end product expression in mouse model of hind limb ischemia
... non-diabetic limb, in response to tissue hypoxia, VEGF is released locally via the HIF-1a pathway and stimulates angiogenesis through multiple mechanisms that include increased proliferation and decreased apop- ...
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Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia
... critical limb ischemia (CLI), the comparison of MSC cellular therapy with angiogenesis gene therapy in CLI, and the proposed mechanism of action of MSC ...hindlimb ischemia, current early-phase human ...
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Intradialytic hypotension is an important risk factor for critical limb ischemia in patients on hemodialysis
... PAD was defined as a unilateral or bilateral ankle- brachial pressure index of < 0.9. At this cut-off point, HD patients with PAD could be detected with 100% spe- cificity as reported in our previous report [10]. CLI ...
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Percutaneous Angioplasty in Diabetic Patients with Critical Limb Ischemia and Chronic Kidney Disease
... From November 2002 to November 2007, a population of 456 diabetic subjects (292 men and 164 women) with critical limb ischemia and foot ulcer was followed at U.O. Diabetic Foot of University of Rome Tor ...
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Limb preservation with suprafascial and thin perforator flaps: salvaging osteomyelitis, Charcot collapse and critical limb ischemia
... In subgroup analysis of our highest risk populations nine diabetic patients had osteomyelitis and three more had critical limb ischemia. Although this is a small sample size, outcomes in this population are ...
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Microcirculatory consequences of limb ischemia/reperfusion in ovariectomized rats treated with zoledronic acid
... tourniquet-induced limb ischemia model, where the role of PMN–endothelial in- teractions in the development of postischemic microcir- culatory inflammatory reactions is well ...
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Role of carbonyl sulfide in acute lung injury following limb ischemia/reperfusion in rats
... Limb I/R-induced ALI animal models were performed the same as previously described in detail [7, 11]. The SD rats were anesthetized via ip administration of sodium pentobarbital (40 mg/kg body weight). An ...
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Stromal vascular fraction cells for the treatment of critical limb ischemia: a pilot study
... Background: Cell-based therapy is being explored as an alternative treatment option for critical limb ischemia (CLI), a disease associated with high amputation and mortality rates and poor quality of life. ...
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<p>Is amputation in the elderly patient with critical limb ischemia acceptable in the long term?</p>
... critical limb ischemia ...critical limb ischemia ...major limb amputation for critical limb ischemia patients, is lacking in ...
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Arterial Pedal Arch Revascularization Impact on the Clinical Results in Critical Lower Limb Ischemia
... lower limb ischemia according to Pokrovsky-Fontaine ...lower limb ischemia of IV class according to Pokrovsky-Fontaine classification were analyzed in the early postoperative period and 1 year ...
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Can Endarterectomy Be Useful in Peripheral Arterial Occlusive Disease with Critical Limb Ischemia?
... critical limb ischemia especially in combination with other procedures in multi- level arterial obstructive disease [3] [4] ...critical limb ischemia due to multilevel arterial obstructive ...
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Hypoxia-sensitive gene expression in the gastrocnemius muscle following chronic hind limb ischemia
... 2 PAD presents itself differently in every patient and about 20% of people with the disease are asymptomatic [1]. The most common symptom of the disease is intermittent claudication (irregular pain) in the extremities, ...
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Successful limb salvage through staged bypass combined with free gracilis muscle transfer for critical limb ischemia with osteomyelitis after failed endovascular therapy
... sistent limb ischemia, even after multiple ...of limb salvage seemed to be low be- cause of the extensive tissue loss with osteomyelitis of the exposed ...of limb salvage considering the ...
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