Lineage differentiation
Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells
... LTβR signaling on adult neurogenesis [9, 87]. We demonstrated strong evidence that LTβR signaling is enriched in NSCs during neural induction and neuro- genesis. Through in situ hybridization and immuno- histochemistry, ...
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Fractalkine receptor is expressed in mature ovarian teratomas and required for epidermal lineage differentiation
... epidermal lineage differen- ...cell differentiation within this benign forma- ...cell differentiation when applying future anti- fractalkine ...
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Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison
... Bone marrow mesenchymal stem cells (BMSCs) have been the most extensively used and investigated MSCs. However, harvesting BMSCs has limitations due to the possible pain and morbidity associated with the bone mar- row ...
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Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia
... osteogenic differentiation but also showed a preference for adipogenic ...of lineage reciprocity of BMMSCs have all been identified as transcription factors [7-9], and researchers have not determined ...
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Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models
... To further and better evaluate the safety and efficacy of our expansion strategy HEM, an in vivo study in the pri- mate model was performed as part of the preclinical evaluation (Fig. 5a). Given that no immunosuppressed ...
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Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis
... complex differentiation process driven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocytes, the giant bone marrow cells that in turn break down to form blood ...
9
Does osteogenic potential of clonal human bone marrow mesenchymal stem/stromal cells correlate with their vascular supportive ability?
... multi-lineage differentiation capacity [20, ...the differentiation capacity of single hBM derived CFU-F clones over time and reported het- erogeneity of their potentiality, with 99% of hBM CFU-F ...
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Differentiation of Neural Stem Cells Into Cells of Oligodendroglial Lineage
... induce differentiation of dissociated neural stem cells derived from mouse embryonic ...cell differentiation was triggered by cell adhesion, re- moval of growth factors and serum-supplemented medium, only ...
7
PubMedCentral-PMC5298956.pdf
... T-bet is important for the differentiation of Th1 cells (64). Therefore, regulation of T-bet gene expression is important to establish Th1 and maintain Th1/Th2 axis as evidenced by the abnormal disease conditions ...
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Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment
... Notch1 is not a T-lineage specific regulator; rather, it is a multilevel factor involved in various aspects of embryonic development. In order to launch a T-specific program, Notch signaling has to collaborate ...
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Therapeutic Potential of Human Adipose Stem Cells in a Rat Myocardial Infarction Model
... After lineage-specific stimulation, ASCs show multiplelineage differentiation including adipogenic, chondrogenic, myogenic, cardiomyogenic, osteogenic, endothelial and neurogenic lineage[r] ...
8
Effects of BIO on proliferation and chondrogenic differentiation of mouse marrow-derived mesenchymal stem cells
... In this study, the effect of BIO on proliferation of mouse marrow derived MSC culture was investigated and the best concentration with mitotic effects was determined. According to our result the presence of 0.1 µM BIO in ...
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Pbx1 dependent control of VMC differentiation kinetics underlies gross renal vascular patterning
... Understanding the transcriptional regulation of Pdgfrb is of high clinical significance. Specifically, organ fibrosis, which is mediated by dysregulated VMC proliferation and differentiation (Bonner, 2004; ...
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Concepts and limitations for learning developmental trajectories from single cell genomics
... of differentiation and cell fates, where likely cell states are depicted as valleys and unlikely cell states as hills, similar to the free energy ...and lineage tree reconstruction are essential for the ...
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Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation
... terminal differentiation myogenic genes Ckm and Myh8 became simultaneously demethy- lated and activated during late differentiation, when iPax7 myogenic precursors differentiated and fused forming ...
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Sequential changes at differentiation gene promoters as they become active in a stem cell lineage
... correct differentiation genes, kept silent in precursor cells, are selectively activated upon the switch to ...to differentiation in stem cell ...during lineage specification (Boyer et ...the ...
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Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation
... demonstrate that EGR-1 mRNA levels are increased in part by transcriptional activation of this gene in M-CSF-stimulated monocytes. The results also demonstrate that both EGR-1 and EGR-2 mRNA levels are regulated at the ...
8
Usp22 deficiency impairs intestinal epithelial lineage specification in vivo
... For H&E staining sections were de-paraffinized, rehydrated and stained in hematoxylin (Merck). After rinsing counterstaining with Eosin (Carl Roth) was carried out until a sufficient staining was obtained. Nissl ...
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A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis
... The formation of mature cells by blood stem cells is very well understood at the cellular level and we know many of the key transcription factors that control fate decisions. However, many upstream signalling and ...
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Interplay of Extrinsic and Intrinsic Cues in Cell-Fate Decisions
... induced lineage is upregulated and the receptor expression corresponding to the other lineage is unchanged or even slightly ...the differentiation experiments to erythrocytic and megakaryocytic ...
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