Linear epitope
The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity
... its epitope residue at asparagine (Asn) 347 on ...the epitope recognized by the neutralizing MAb is essential for HHV-6A ...the epitope of the neutralizing MAb is located on domain II of gB and is ...
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Deletions of Structural Glycoprotein E2 of Classical Swine Fever Virus Strain Alfort/187 Resolve a Linear Epitope of Monoclonal Antibody WH303 and the Minimal N-Terminal Domain Essential for Binding Immunoglobulin G Antibodies of a Pig Hyperimmune Serum
... the epitope recognized by WH303 was a 9-mer peptide TAVSPTTLR between aa 829 and ...a linear epitope to a few residues in the C-terminal membrane-spanning region of the CSFV strain Brescia E2, which ...
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Probing Zika Virus Neutralization Determinants with Glycoprotein Mutants Bearing Linear Epitope Insertions
... of linear epitope sequences and the potential of antibodies that bind these epitopes to inhibit ...FLAG epitope inserted in the premembrane (prM) and envelope (E) glyco- protein ...nearby ...
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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
... microarray linear epitope ...Notably, linear V2 binding data generated by peptide microarray correlated with a decreased risk of infection in the RV144 efficacy trial ...all linear epitopes ...
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Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus
... gion has had to be deleted from all GPs crystallized (11, 22). Thus, even though we have structural information on the lower core of GP, there is no structural information on the mucin-like domain, save one structure of ...
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Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein
... The major antigenic determinants of picornaviruses are usually found on the VP1 capsid protein. This poses the problem of generating universal antibodies against all subgenogroups of a virus strain, as the VP1 sequence ...
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Characterization of C-strain “Riems” TAV-epitope escape variants obtained through selective antibody pressure in cell culture
... Classical swine fever virus (CSFV) is one of the most im- portant pathogens affecting domestic pigs and wild boar [1]. CSFV, together with Border disease virus (BDV) and Bovine viral diarrhea virus (BVDV), is grouped ...
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Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process.
... antibody epitope conformation dependence that had not been previously employed in this system, we observed that the humoral immune response to EIAV required a 6- to 8-month period in which to fully ...
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American Journal of Medical and Biological Research
... immune epitope database ...Bepipred linear epitope prediction analysis and T cell epitopes using Major Histocompatibility Complex class I and ll binding prediction tool based on Stabilized Matrix ...
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A neutralizing epitope of human papillomavirus type 11 is principally described by a continuous set of residues which overlap a distinct linear, surface-exposed epitope.
... a linear surface epitope in that they bind HPV11:2 VLPs in both assembled and denatured ...this linear epitope overlaps the binding site of the neutralizing ...evaluating linear regions ...
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Identification of a novel linear B cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates
... defined epitope, which demonstrates less conserved between different CDV ...the linear epitope, we ana- lyzed these sequences from Chinese isolates in domestic dogs during ...identified ...
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An Integrated In-Silico Approach to Develop Epitope-Based Peptide Vaccine against SARS-CoV-2
... B-cell epitope was Bepipred linear epitope prediction tool ...of linear B-cell ...Bepipred linear epitope prediction tool ...
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Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.
... recognizing linear epitopes within HTLV-1 gp46 were isolated. The epitope recognized by HMAb PRH-1 is located between amino acids 260 and 294 of HTLV-1 ...the epitope recognized by PRH-1 is ...
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Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope
... with linear peptides, indicating that the engineered cyclic variants are superior ...outside epitope I capable of inducing neutralizing antibodies (41, 42), though, as noted by others, at least one such ...
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Computational Methods in Linear B cell Epitope Prediction
... 701 linear B-cell epitopes, extracted from Bcipep database, and 701 non-epitopes, randomly extracted from ...length linear B-cell ...predict linear B-cell epitopes of diverse lengths ...method. ...
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Epitope specificity determines pathogenicity and detectability in ANCA associated vasculitis
... setts General Hospital), and all were confirmed ANCA negative. Protein lysate of total peripheral blood leukocytes was probed for antigen or antigens reactive with purified total Ig from ANCA- negative AAV patients’ sera ...
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Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F
... a linear epitope in the RSV fusion ...the linear epitope and the interactions of residues that are mutated in antibody escape ...peptide epitope ⬃ 16,000-fold more weakly than the ...
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Journal of Applied & Environmental Microbiology
... Bepipred Linear Epitope Prediction, Emini surface accessibility and Kolaskar and Tongaonkar antigenicity method in the IEDB, based on the default threshold of the prediction ...Bepipred Linear ...
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Mannosylated linear and cyclic single amino acid mutant peptides using a small 10 amino acid linker constitute promising candidates against Multiple Sclerosis
... immune response from Th1 to Th2 enhancing the induction of anti-inflammatory cytokines IL-4 and IL-10 (30–35). In these studies, the cyclic and linear APLs were conjugated to KLH fol- lowed by conjugation to ...
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Cyclic MOG₃₅–₅₅ ameliorates clinical and neuropathological features of experimental autoimmune encephalomyelitis
... 33. Matsoukas, J.; Apostolopoulos, V.; Kalbacher, H.; Papini, A. M.; Tselios, T.; Chatzantoni, K.; Biagioli, T.; Lolli, F.; Deraos, S.; Papathanassopoulos, P.; Troganis, A.; Mantzourani, E.; Mavromoustakos, T.; Mouzaki, ...
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